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Migration of microsomal autoantigens to the hepatocyte plasma membrane

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Immunology and Liver

Part of the book series: Falk Symposium ((FASS,volume 114))

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Abstract

Autoantibodies against microsomal autoantigens are present in some forms of drug-induced hepatitis, alcohol-induced liver injury, idiopathic autoimmune hepatitis, and viral hepatitis. For these autoantibodies to play a role in immune destruction the microsomal autoantigens would have to be inserted in, or transported to, the plasma membrane (PM) and would have to be exposed, at least in part, on the outer surface of the PM. The present review is mainly concerned with the immunogenicity, cellular transport, and PM expression of cytochromes P450 (CYP). Other microsomal autoantigens are briefly discussed.

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Authors
  1. D. Pessayre
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  2. V. Descatoire
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  3. P. Dansette
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  4. J. Loeper
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  5. A. Berson
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  6. M.-A. Robin
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Editor information

Editors and Affiliations

  1. Abt. Gastroenterologie/Hepatologie Zentrum Innere Medizin, Medizinische Hochscule Hannover, Carl-Neuberg Str. 1, D-30625, Hannover, Germany

    M. P. Manns

  2. Medizinische Klinik II, Klinikum Grosshadern der LMU München, Marchioninistr. 15, D-81377, München, Germany

    G. Paumgartner

  3. Abt. Gastroenterologie Zentrum der Innere Medizin, Klinikum der Johann-Wolfgang-Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, D-60596, Frankfurt, Germany

    U. Leuschner

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Pessayre, D., Descatoire, V., Dansette, P., Loeper, J., Berson, A., Robin, MA. (2000). Migration of microsomal autoantigens to the hepatocyte plasma membrane. In: Manns, M.P., Paumgartner, G., Leuschner, U. (eds) Immunology and Liver. Falk Symposium, vol 114. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4000-3_3

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  • DOI: https://doi.org/10.1007/978-94-011-4000-3_3

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