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Thoughts on the infectious aetiology of primary biliary cirrhosis

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Immunology and Liver

Part of the book series: Falk Symposium ((FASS,volume 114))

Abstract

Primary biliary cirrhosis (PBC) is characterized by features consistent with autoimmune aetiological mechanisms. However, the initiating events in autoimmunity, by which tolerance to self-antigens is broken, are still poorly understood. Indeed, as will be considered, characteristic features of infection and autoimmunity are not mutually exclusive. Recent reports increasingly lend support to earlier speculation and hypotheses that proposed involvement of infectious agents in aetiological mechanisms in autoimmunity. Conversely, autoimmune phenomena are associated with certain infections. It has long been suggested that some features of PBC may have more in common with a response to infection than an autoimmune reaction. Evidence for involvement of an infectious agent in the aetiology of PBC will be considered in this chapter.

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Authors
  1. R. Joplin
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Editors and Affiliations

  1. Abt. Gastroenterologie/Hepatologie Zentrum Innere Medizin, Medizinische Hochscule Hannover, Carl-Neuberg Str. 1, D-30625, Hannover, Germany

    M. P. Manns

  2. Medizinische Klinik II, Klinikum Grosshadern der LMU München, Marchioninistr. 15, D-81377, München, Germany

    G. Paumgartner

  3. Abt. Gastroenterologie Zentrum der Innere Medizin, Klinikum der Johann-Wolfgang-Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, D-60596, Frankfurt, Germany

    U. Leuschner

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© 2000 Springer Science+Business Media Dordrecht

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Joplin, R. (2000). Thoughts on the infectious aetiology of primary biliary cirrhosis. In: Manns, M.P., Paumgartner, G., Leuschner, U. (eds) Immunology and Liver. Falk Symposium, vol 114. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4000-3_23

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  • DOI: https://doi.org/10.1007/978-94-011-4000-3_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5768-4

  • Online ISBN: 978-94-011-4000-3

  • eBook Packages: Springer Book Archive

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