Abstract
At least eight human cytochrome P450s are recognized by autoantibodies associated with either alcoholic liver disease, autoimmune polyendocrinopathy, autoimmune hepatitis or drug-induced autoimmunity (Table 1). The poly specific responses to both conformational and linear epitopes that have been characterized for autoantibodies to P450 2D6 in LKM-1-positive autoimmune hepatitis suggests that the autoimmune response is directed towards the P4501-7. Although the other P450 antigens listed in Table 1 have not yet received the same level of scrutiny, these enzymes nevertheless appear to be relatively specific targets for autoimmune responses.
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Griffin, K.J., Johnson, E.F. (2000). The cytochrome P450 supergene family: genetic organization and function. In: Manns, M.P., Paumgartner, G., Leuschner, U. (eds) Immunology and Liver. Falk Symposium, vol 114. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4000-3_15
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