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Reactivity of autoimmune hepatitis sera with glutathione S-transferase

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Immunology and Liver

Part of the book series: Falk Symposium ((FASS,volume 114))

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Abstract

Autoimmune hepatitis (AIH)1-4, an inflammatory liver disease, represents histologically and serologically a broad spectrum of characteristic features. The classification of AIH is primarily based on serological criteria. Type I AIH is defined by antibodies to nuclei (ANA) and eventually actin, while type II AIH is characterized by antimicrosomal antibodies recognizing cytochrome P450IID62-6. Moreover, a substantial number of AIH patients7-11 produce antibodies to a cytosolic soluble antigen7-10, either alone or in combination with antinuclear and/or smooth muscle antibodies (SMA). One may assume that these patients represent a distinct AIH subgroup. However, two different cytosolic antigens have been described: liver-pancreas-specific antigen (LP)12 and soluble liver antigen (SLA)7. From originally described characteristics and a careful comparison of the isolation procedure it can be deduced that the antigens are identical. Both antigens were defined as non-species-, non-organ-specific, despite their highest concentration being in the liver. According to the published protocols they were obtained as a supernatant after extensive ultracentrifugation of the tissue9 homogenates, indicating their extremely high solubility. Moreover, both antigens represent a very heterogeneous fraction, consisting of at least 100 different proteins. Therefore, one might expect that human autoantibodies would exhibit specificity against more than a single antigen target.

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Authors
  1. J. Węsierska-Gądek
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  2. E. Penner
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Editor information

Editors and Affiliations

  1. Abt. Gastroenterologie/Hepatologie Zentrum Innere Medizin, Medizinische Hochscule Hannover, Carl-Neuberg Str. 1, D-30625, Hannover, Germany

    M. P. Manns

  2. Medizinische Klinik II, Klinikum Grosshadern der LMU München, Marchioninistr. 15, D-81377, München, Germany

    G. Paumgartner

  3. Abt. Gastroenterologie Zentrum der Innere Medizin, Klinikum der Johann-Wolfgang-Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, D-60596, Frankfurt, Germany

    U. Leuschner

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© 2000 Springer Science+Business Media Dordrecht

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Węsierska-Gądek, J., Penner, E. (2000). Reactivity of autoimmune hepatitis sera with glutathione S-transferase. In: Manns, M.P., Paumgartner, G., Leuschner, U. (eds) Immunology and Liver. Falk Symposium, vol 114. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-4000-3_14

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  • DOI: https://doi.org/10.1007/978-94-011-4000-3_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5768-4

  • Online ISBN: 978-94-011-4000-3

  • eBook Packages: Springer Book Archive

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