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Copper and Zinc in Inflammatory and Degenerative Diseases pp 161–172Cite as

Copper and zinc compounds and cell surface interactions

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Abstract

The essential requirement of copper and zinc for normal bone and cartilage development, and the efficacy of copper and zinc compounds as anti-inflammatory and anti-arthritic agents have been well established, based primarily on a wealth of evidence from studies of dietary copper and zinc deficiency and supplementation in laboratory animals and man [1–5]. Surprisingly few studies have, however, focused on the mechanisms of action of copper and zinc at the molecular level. The aim of this brief review is to present current knowledge of the effects of copper and zinc at the cell surface, and to discuss mechanisms whereby modification of cellular interactions by these trace metals may play a role in inflammatory and degenerative diseases.

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Author information

Authors and Affiliations

  1. Strangeways Research Laboratory, Cambridge, UK

    M. E. Davies & M. Pasqualicchio

  2. Instituto de Farmacologia, Università di Verona, Policlinico Borgo Roma, 37134, Verona, Italy

    M. E. Davies & M. Pasqualicchio

Authors
  1. M. E. Davies
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  2. M. Pasqualicchio
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Editor information

Editors and Affiliations

  1. Division of Biomedical Sciences, School of Science and Mathematics, Sheffield Hallam University, Pond Street, S1 1WB, Sheffield, UK

    K. D. Rainsford

  2. Institute of Pharmacology, University of Verona, Policlinico di Borgo Roma, I-37134, Verona, Italy

    R. Milanino

  3. Department of Pharmacy, University of Arkansas for Medical Science Campus, 4301 W. Markham, Slot 522, 72205, Little Rock, AR, USA

    J. R. J. Sorenson

  4. Institute of Pharmacology, University of Verona, Verona, Italy

    G. P. Velo

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Davies, M.E., Pasqualicchio, M. (1998). Copper and zinc compounds and cell surface interactions. In: Rainsford, K.D., Milanino, R., Sorenson, J.R.J., Velo, G.P. (eds) Copper and Zinc in Inflammatory and Degenerative Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3963-2_11

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  • DOI: https://doi.org/10.1007/978-94-011-3963-2_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5757-8

  • Online ISBN: 978-94-011-3963-2

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