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The amphibiotic relationship of Helicobacter pylori and humans

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Abstract

Medical science, as with most organized human activities, is subject to fashion and fad. The major scientific advances in the first half of the twentieth century, encompassed by the development of microbiology and improvements in public health, led to a marked reduction in the morbidity and mortality due to infectious diseases. Following the discovery and widespread use of antibiotics, society had become complacent about the role of infectious diseases as threats to humankind. However, the plagues of the acquired immunodeficiency syndrome (AIDS), and the development of multiply-resistant Mycobacterium tuberculosis, among others, have led to a sea-change in our attitudes about infectious diseases. Now we are at ‘war’ against microbes, and concerned about killer strains (‘flesh-eating bacteria’, for example), and distant epidemics. The threat of infectious diseases, once thought to be under control, clearly is not gone.

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References

  1. Savage DC. Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol. 1977;31:107–133.

    Article  PubMed  CAS  Google Scholar 

  2. Ruby EG. Lessons from a cooperative, bacterial-animal association: the Vibrio fischeri-Euprymna scolopes light organ symbiosis. Annu Rev Microbiol. 1996;50:591–624.

    Article  PubMed  CAS  Google Scholar 

  3. McFall-Ngai MJ. The development of cooperative associations between animals and bacteria: establishing détente among domains. Am Zool. 1998;38:593–608.

    CAS  Google Scholar 

  4. Long SS, Swenson RM. Determinants of the developing oral flora in normal newborns. Appl Environ Microbiol. 1976;32:494–497.

    PubMed  CAS  Google Scholar 

  5. McClellan DL, Griffen AL, Leys EJ. Age and prevalence of Porphyromonas gingivalis in children. J Clin Microbiol. 1996;34:2017–2019.

    PubMed  CAS  Google Scholar 

  6. Hill GB, St Claire KK, Gutman LT. Anaerobes predominate among the vaginal microflora of prepubertal girls. Clin Infect Dis. 1995;20(Suppl. 2):S269–S270.

    Article  PubMed  Google Scholar 

  7. Blaser MJ. Science, medicine, and the future: Helicobacter pylori and gastric diseases. Br MedJ. 1998;316:1507–1510.

    Article  CAS  Google Scholar 

  8. Evans AS. Causation and disease: the Henle-Koch postulates revisited. Yale J Biol Med. 1976;49:175–195.

    PubMed  CAS  Google Scholar 

  9. Fredricks DN, Relman DA. Sequence-based identification of microbial pathogens: a reconsideration of Koch’s postulates. Clin Microbiol Rev. 1996;9:18–33.

    Google Scholar 

  10. Hill AB. The environment and disease: association or causation. President’s address; Proceedings of the Royal Society of Medicine Meeting, 14 Jan 1965, Section of Occupational Medicine, pp. 295–300.

    Google Scholar 

  11. Rosebury T. Microorganisms Indigenous to Man. New York: McGraw Hill; 1962:1–8.

    Google Scholar 

  12. Mackowiak P. The normal microbial flora. N Engl J Med. 1982;307:83–93.

    Article  PubMed  CAS  Google Scholar 

  13. Goldstein EJC, Citron DM, Wield B et al. Bacteriology of human and animal bite wounds. J Clin Microbiol. 1978;8:667–672.

    PubMed  CAS  Google Scholar 

  14. Blaser MJ. Helicobacters are indigenous to the human stomach: duodenal ulcération is due to changes in gastric microecology in the modern era. Gut. 1998;43:721–727.

    Article  PubMed  CAS  Google Scholar 

  15. Kosunen TU, Aromaa A, Knekt P et al. Helicobacter antibodies in 1973 and 1994 in the adult population of Vammala, Finland. Epidemiol Infect. 1997;119:29–34.

    Article  PubMed  CAS  Google Scholar 

  16. Blaser MJ. The changing relationships of Helicobacter pylori and humans: implications for health and disease. J Infect Dis. 1999;179:1523–1530.

    Article  PubMed  CAS  Google Scholar 

  17. El-Omar E, Penman I, Dorrian CA, Ardill JE, McColl KE. Eradicating Helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer. Gut. 1993;34:1060–1065.

    Article  PubMed  CAS  Google Scholar 

  18. Mattsson A, Lonroth H, Quiding-Jarbrink M, Svennerholm AM. Induction of B cell responses in the stomach of Helicobacter pylori-infected subjects after oral cholera vaccination. J Clin Invest. 1998;102:51–56.

    Article  PubMed  CAS  Google Scholar 

  19. Putsep K, Branden CI, Boman HG, Normark S. Antibacterial peptide from H. pylori. Nature. 1999;398:671–672.

    Article  PubMed  CAS  Google Scholar 

  20. Sutter VL. Anaerobes as normal oral flora. Rev Infect Dis. 1984;6(Suppl. 1):S62–6.

    Article  PubMed  Google Scholar 

  21. Rolfe RD. Interactions among microorganisms of the indigenous intestinal flora and their influence on the host. Rev Infect Dis. 1984;6(Suppl. 1):S73–79.

    Article  PubMed  Google Scholar 

  22. Covler TL, Dooley CP, Blaser MJ. Characterization and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect Immun. 1990;58:603–610.

    Google Scholar 

  23. Crabtree JE, Taylor JD, Wyatt JL et al. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulcération, and gastric pathology. Lancet. 1991;338:332–335.

    Article  PubMed  CAS  Google Scholar 

  24. Blaser MJ, Pérez-Pérez GL, Kleanthous H et al. Infection with Helicobacter pylori strains possessing cagA associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 1995;55:2111–2115.

    PubMed  CAS  Google Scholar 

  25. Parsonnet J, Friedman GD, Orenterich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut. 1997;40:297–301.

    PubMed  CAS  Google Scholar 

  26. Blaser MJ. The interaction of cag+ Helicobacter pylori with their hosts. In: Hunt RH, Tytgat GNJ, editors. Helicobacter pylori, Basic Mechanisms to Clinical Cure. Dordrecht: Kluwer; 1998;27–32.

    Chapter  Google Scholar 

  27. Kuipers EJ, Pérez-Pérez GI, Meuwissen SGM, Blaser MJ. Helicobacter pylori and atrophic gastritis: importance of the cagA status. J Natl Cancer Inst. 1995;87:1777–1780.

    Article  PubMed  CAS  Google Scholar 

  28. Blaser MJ. Ecology of Helicobacter pylori in the human stomach. J Clin Invest. 1997;100:759–762.

    Article  PubMed  CAS  Google Scholar 

  29. Kuipers EJ, Israel DA, Küsters JG et al. Quasispecies development of Helicobacter pylori observed in paired isolates obtained years apart in the same host. J Infect Dis. 2000;181:273–282.

    Article  PubMed  CAS  Google Scholar 

  30. Kroes I, Lepp PW, Relman DA. Bacterial diversity within the human subgingival crevice. Proc Natl Acad Sci USA. 1999;96:14547–14552.

    Article  PubMed  CAS  Google Scholar 

  31. Croucher SC, Houston AP, Bayliss CE, Turner RJ. Bacterial populations associated with different regions of the human colon wall. Appl Environ Microbiol. 1983;45:1025–1033.

    PubMed  CAS  Google Scholar 

  32. Bartlett JG, Polk BF. Bacterial flora of the vagina: quantitative study. Rev Infect Dis. 1984;6(Suppl. 1):S67–72.

    Article  PubMed  Google Scholar 

  33. Odenbreit S, Puls J, Sedlmaier B, Gerland E, Fischer W, Haas R. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science. 2000;287:1497–1500.

    Article  PubMed  CAS  Google Scholar 

  34. Feldman M, Cryer B, Sammer D, Lee E, Spechler SJ. Influence of H. pylori infection on meal-stimulated gastric acid secretion and gastroesophageal acid reflux. Am J Physiol. 1999;277:1159–1164.

    Google Scholar 

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© 2000 Springer Science+Business Media Dordrecht

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Blaser, M.J. (2000). The amphibiotic relationship of Helicobacter pylori and humans. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3927-4_3

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  • DOI: https://doi.org/10.1007/978-94-011-3927-4_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5753-0

  • Online ISBN: 978-94-011-3927-4

  • eBook Packages: Springer Book Archive

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