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Proton pump inhibitors do not accelerate the development of gastric atrophy in Helicobacter pylori gastritis

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Helicobacter pylori

Abstract

Kuipers and colleagues1 suggested in 1996 that long-term acid suppression by omeprazole accelerates the development of atrophic gastritis in patients infected with Helicobacter pylori. This, in turn, may facilitate the development of intestinal metaplasia, dysplasia, and gastric adenocarcinoma. This report received widespread media attention because of the public perception, particularly in the United States, that the increasing use of proton pump inhibitors (PPIs), already suspected to be carcinogenic, would cause even more cancer, given the ubiquity of H. pylori infection and gastro-oesophageal reflux disease (GERD) in the general population. The Food and Drug Administration (FDA) convened an urgent meeting to determine if PPIs should be removed from the market or have substantial changes in approved indications and directions for use.

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Authors
  1. J. W. Freston
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Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine Director) (Professor of Medicine Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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Freston, J.W. (2000). Proton pump inhibitors do not accelerate the development of gastric atrophy in Helicobacter pylori gastritis. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3927-4_29

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  • DOI: https://doi.org/10.1007/978-94-011-3927-4_29

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5753-0

  • Online ISBN: 978-94-011-3927-4

  • eBook Packages: Springer Book Archive

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