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The inflamatory activity in Helicobacter pylori infection is predominantly organism related

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Helicobacter pylori

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Abstract

Helicobacter pylori is remarkably adapted to survival in its niche on the surface of the human gastric mucosa. It persists for decades with minimal damage in the majority of those infected. Nevertheless, infection is almost invariably associated with some degree of chronic active gastritis. The intensity of this inflammation of the gastric mucosa has been correlated with the risk of developing complications of the infection such as peptic ulcer, and the inflammation invariably abates after successful elimination of the infection. To modulate the host response, H. pylori has evolved a complex set of genes. Recent genetic studies contributed to defining the function of some of these genes. In addition, these studies, as well as the analysis of the two complete genomes of H. pylori, have provided important information regarding the mechanisms by which H. pylori modulates gene expression. Gene regulation allows the pathogen to further adapt to its environment and to further modulate its relationship to its host, including inflammation.

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Authors
  1. P. Michetti
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Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine Director) (Professor of Medicine Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 2000 Springer Science+Business Media Dordrecht

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Michetti, P. (2000). The inflamatory activity in Helicobacter pylori infection is predominantly organism related. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3927-4_21

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  • DOI: https://doi.org/10.1007/978-94-011-3927-4_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5753-0

  • Online ISBN: 978-94-011-3927-4

  • eBook Packages: Springer Book Archive

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