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Overview of immune and inflammatory changes due to Helicobacter infection

  • Chapter
Helicobacter pylori

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Abstract

Helicobacter pylori infection causes gastric inflammation and is linked to the development of duodenal and gastric ulceration, gastric atrophy and gastric cancer. The high prevalence of Helicobacter pylori infection in the world, and its link to these diseases, makes this one of the world’s leading health problems1. Eradication of H. pylori infection prevents ulcer recurrence and treatment of H. pylori infection is indicated in all patients with peptic ulcer disease as well as MALT lymphoma. On the other hand, the benefits of treating all H. pylori-infected patients remains controversial given the cost of treatment, the concerns regarding the side-effects of antibiotics and the increasing incidence of antibiotic-resistant H. pylori strains2,3. Nonetheless, as the strength of the evidence for an association between H. pylori and dyspepsia and, more importantly, gastric cancer increases, the arguments in favour of treating all H. pylori-infected patients become more convincing. Therefore, there is a need for new treatment strategies that can be applied to large populations2,4.

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Authors
  1. A. Hamlet
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  2. K. Croitoru
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Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine Director) (Professor of Medicine Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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Hamlet, A., Croitoru, K. (2000). Overview of immune and inflammatory changes due to Helicobacter infection. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3927-4_14

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  • DOI: https://doi.org/10.1007/978-94-011-3927-4_14

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