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Establishment and Characteristics of Human Colorectal Adenocarcinoma Cell Lines

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Epithelia

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Abstract

Many biological studies of colorectal carcinoma require the availability of established cell lines. These cell lines provide an unlimited quantity of carcinoma cells without contamination with the other cell types found in profusion in primary tumours. The characteristics of established cell lines differ widely. A bank of these cell lines, reflecting some of the diversity observed in primary human colorectal carcinoma, is a useful tool with which to study the biology of colorectal carcinoma cells. In addition, some of these cell lines retain sufficient of the differentiated features characteristic of the normal epithelium to make them useful model systems with which to study the functions of colorectal epithelium. This is particularly useful in light of the inability to establish differentiating cultures from normal colorectal epithelium.

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  1. S. C. Kirkland
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Editors and Affiliations

  1. Division of Biomedical Sciences, University of California, Riverside, CA, USA

    Christopher J. Jones

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© 1990 Springer Science+Business Media Dordrecht

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Kirkland, S.C. (1990). Establishment and Characteristics of Human Colorectal Adenocarcinoma Cell Lines. In: Jones, C.J. (eds) Epithelia. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3905-2_3

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  • DOI: https://doi.org/10.1007/978-94-011-3905-2_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5739-4

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