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Abstract

The issues that pertain to arthritis in pregnancy differ from those of the other chapters in this book by virtue of the finite duration of the gestational period. The key issues relate to the effects of pregnancy on the musculoskeletal condition and the effects of the musculoskeletal condition on pregnancy. This broader categorization is preferred to that which limits the discussion to the interaction between pregnancy and the articular condition, since in some disorders, e.g., SLE, the severity and progression of major organ involvement outweighs any articular effects. In addition to discussing gestational effects in the major musculoskeletal conditions, this chapter also examines, where relevant, issues relating to fertility, the post-partum period and drug effects in pregnancy and lactation. Although an attempt will be made to discuss the outcomes according to the paradigm advanced by Fries1, it is of note that economic outcomes (dollar costs) are poorly delineated, most investigators exploring the incidence of maternal and fetal fatality (death), the fluctuating severity of pain (discomfort) and suffering (disability), and the effects of pharmacologic therapy (iatrogenic effects).

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References

  1. Fries, J. F. (1983). Toward an understanding of patient outcome measurement. Arthritis Rheum., 26, 297–704.

    Google Scholar 

  2. Hench, P. S. (1938). A meliorating effect of pregnancy on chronic atrophic (infectious) rheumatoid arthritis, fibrositis and intermittent hydrarthrosis. Proc. Mayo Clin., 13, 161–167.

    Google Scholar 

  3. Bellamy, N. (1982). In vitro studies on immunoregulation with special reference to rheumatoid arthritis. MD Thesis, Glasgow University, pp. 9-14.

    Google Scholar 

  4. A committee of the American Rheumatism Association. (1959). Revision of diagnostic criteria for rheumatoid arthritis. Arthritis Rheum., 2, 16–20.

    Google Scholar 

  5. Mitchell, D. M., Spitz, P. W., Young, D. Y., Bloch, D. A., McShane, D. J. and Fries, J. F. (1986). Survival prognosis and causes of death in rheumatoid arthritis. Arthritis Rheum., 29(6), 706–714.

    PubMed  CAS  Google Scholar 

  6. Ehrlich, G. E. (1978). Restoring arthritics first loss. Sexual Medicine Today, 2, 6–8.

    Google Scholar 

  7. Yoshino, S. and Uchida, S. (1981). Sexual problems of women with rheumatoid arthritis. Arch. Phys. Med. Rehabil., 62, 122–123.

    PubMed  CAS  Google Scholar 

  8. Kay, A. and Bach, F. (1965). Subfertility before and after the development of rheumatoid arthritis in women. Ann. Rheum. Dis., 24, 169–173.

    PubMed  CAS  Google Scholar 

  9. Hargreaves, E. R. (1958). A survey of rheumatoid arthritis in west Cornwall. A report to the Empire Rheumatism Council. Ann. Rheum. Dis., 17, 61–75.

    PubMed  CAS  Google Scholar 

  10. Klipple, G. L. and Cecere, F. A. (1989). Rheumatoid arthritis and pregnancy. Rheum. Dis. Clin. North Am., 15(2), 213–239.

    PubMed  CAS  Google Scholar 

  11. Silman, A. J. (1986). Is pregnancy a risk factor in the causation of rheumatoid arthritis. Ann. Rheum. Dis., 45, 1031–1034.

    PubMed  CAS  Google Scholar 

  12. Oka, M. (1953). Effect of pregnancy on the onset on course of rheumatoid arthritis. Ann. Rheum. Dis., 73, 227–229.

    Google Scholar 

  13. Oka, M. and Vainio, U. (1966). Effect of pregnancy on the prognosis and serology of rheumatoid arthritis. Acta Rheum. Scand., 12, 47–52.

    PubMed  CAS  Google Scholar 

  14. Felbo, M. and Snorrason, E. (1961). Pregnancy and the place of therapeutic abortion in rheumatoid arthritis. Acta Obstet. Gynecol. Scand., 40, 116–126.

    PubMed  CAS  Google Scholar 

  15. Betson, J. R. and Dorn, R. V. (1964). Forty cases of arthritis and pregnancy. J. Int. Coll. Surg., 42(5), 521–526.

    PubMed  Google Scholar 

  16. Kaplan, D. and Diamond, H. (1965). Rheumatoid arthritis and pregnancy. Clin. Obstet. Gynecol., 8(2), 286–303.

    Google Scholar 

  17. Morris, W. I. C. (1969). Pregnancy in rheumatoid arthritis and systemic lupus erythematosus. Aust. N. Z. J. Obstet. Gynaecol., 9, 136–144.

    PubMed  CAS  Google Scholar 

  18. Persellin, R. H. (1977). The effect of pregnancy on rheumatoid arthritis. Bull. Rheum. Dis., 27(9), 922–927.

    CAS  Google Scholar 

  19. Neely, N. T. and Persellin, R. H. (1977). Activity of rheumatoid arthritis during pregnancy. Texas Med., 73, 59–63.

    CAS  Google Scholar 

  20. Cecere, F. A. and Persellin, R. H. (1981). The interaction of pregnancy and the rheumatic diseases. Clin. Rheum. Dis., 7(3), 747–768.

    Google Scholar 

  21. Unger, A., Kay, A., Griffin, A. J. and Panayi, G. S. (1983). Disease activity and pregnancy associated alpha-2-glycoprotein in rheumatoid arthritis during pregnancy. Br. Med. J., 286, 750–752.

    CAS  Google Scholar 

  22. Ostensen, M., Aune, B. and Husby, G. Effect of pregnancy and hormonal changes on the activity of rheumatoid arthritis. Scand. J. Rheumatol., 12, 69-72.

    Google Scholar 

  23. Ostensen, M. and Husby, G. (1983). A prospective clinical study of the effect of pregnancy on rheumatoid arthritis and ankylosing spondylitis. Arthritis Rheum., 26(9), 1155–1159.

    PubMed  CAS  Google Scholar 

  24. Harris, C. J. (1985). Rheumatoid arthritis and the pregnant woman. Am. J. Nursing, 85, 414–417.

    CAS  Google Scholar 

  25. Urowitz, M. B. and Gladman, D. D. (1982). Rheumatic diseases. In Burrow G. N. and Farris, T. F. (eds.) Medical Complications During Pregnancy, pp. 474–497 (Philadelphia: W. B. Saunders).

    Google Scholar 

  26. Sibley, J. T. (1986). Pregnancy and benign rheumatoid nodules. Am. J. Med., 81, 1124.

    PubMed  CAS  Google Scholar 

  27. Mor-Yosef, S., Navot, D., Rabinovwitz, R. and Schenker, J. G. (1984). Collagen diseases in pregnancy. Obstet Gynecol. Surv., 39(2), 67–84.

    PubMed  CAS  Google Scholar 

  28. Kaplan, D. (1986). Fetal wastage in patients with rheumatoid arthritis. J. Rheumatol, 13, 875–877.

    PubMed  CAS  Google Scholar 

  29. Silman, A. J., Roman, E., Beral, V. and Brown, A. (1988). Adverse reproductive outcomes in women who subsequently develop rheumatoid arthritis. Ann. Rheum. Dis., 47, 979–981.

    PubMed  CAS  Google Scholar 

  30. Siamopoulou-Mavridou, A., Manoussakis, M. N., Maviridis, A. K. and Moutsopoulos, H. M. (1988). Outcome of pregnancy in patients with autoimmune rheumatic disease before the disease onset. Ann. Rheum. Dis., 47, 982–987.

    PubMed  CAS  Google Scholar 

  31. McHugh, N. J., Reilly, P. A. and McHugh, L. A. (1989). Pregnancy outcome and autoantibodies in connective tissue disease. J. Rheumatol., 16, 42–46.

    PubMed  CAS  Google Scholar 

  32. Duhring, J. L. (1970). Pregnancy, rheumatoid arthritis and intra uterine growth retardation. Am. J. Obstet. Gynecol., 108(2), 325–326.

    PubMed  CAS  Google Scholar 

  33. Bulmash, J. M. (1979). Rheumatoid arthritis and pregnancy. Obstet. Gynaecol Annu., 8, 223–276.

    CAS  Google Scholar 

  34. Thurnau, G. R. (1983). Rheumatoid arthritis. Clin. Obstet. Gynaecol., 26(3), 558–578.

    CAS  Google Scholar 

  35. Nicholas, N. S. (1988) Rheumatic diseases in pregnancy. Br. J. Hosp. Med., 39, 50–53.

    PubMed  CAS  Google Scholar 

  36. Persellin, R. H., Wiginton, D. A. F., Rutstein, J. E. et al (1982). Pregnancy alphaglycoprotein (PAG) and rheumatoid arthritis (RA) activity: a prospective analysis during gestation. Arthritis Rheum., 25 (Suppl. April), 56.

    Google Scholar 

  37. Unger, A., Kay, A., Griffin, A. J. et al. (1983). Disease activity and pregnancy associated alpha-2-glycoprotein in rheumatoid arthritis during pregnancy. Br. Med. J. (Clin. Res.), 5, 750–752.

    Google Scholar 

  38. Ostensen, M., von Schoultz, B. and Husby, G. (1983). Comparison between serum alpha-2-pregnancy-associated globulin and activity in rheumatoid arthritis and ankylosing spondylitis during pregnancy. Scand. J. Rheumatol., 12, 315–318.

    PubMed  CAS  Google Scholar 

  39. Wallace, D. J., Goldfinger, D. and Klinenberg, J. R. (1987). Use of autologous pregnancy plasma to treat a flare of juvenile rheumatoid arthritis: a case report and literature review. J. Clin. Apheresis, 3(4), 216–218.

    PubMed  CAS  Google Scholar 

  40. Bango, M. Y., Garcia Paez, J. M., Solovera, J. J. et al. (1985). Adult onset Still’s disease: a case with onset during pregnancy. Arthritis Rheum., 28(8), 957.

    Google Scholar 

  41. Katz, W. E., Starz, T. W. and Winkelstein, A. (1990). Recurrence of adult Still’s disease after pregnancy. J. Rheumatol., 17, 373–374.

    PubMed  CAS  Google Scholar 

  42. Stein, G. H., Cantor, B. and Panush, R. S. (1980). Adult Still’s disease associated with pregnancy. Arthritis Rheum., 23(2), 248–250.

    PubMed  CAS  Google Scholar 

  43. Masi, A. T. and Medsger, T. A. (1979). A new look at the epidemiology of ankylosing spondylitis and related syndromes. Clin. Orthop., 143, 15.

    PubMed  Google Scholar 

  44. Hart, F. D. (1980). Clinical features and complications. In Moll, J. M. H. (ed.) Ankylosing Spondylitis, p. 52. (Edinburgh: Churchill Livingstone).

    Google Scholar 

  45. Hart, F. D. (1980). Bechterew’s syndrome in women: is it different from that in men? Scand. J. Rheumatol., Suppl. 32, 38–40.

    Google Scholar 

  46. Marks, S. H., Barnett, M. and Calin, A. (1983). Ankylosing spondylitis in women and men: A case-control study. J. Rheumatol., 10, 624–628.

    PubMed  CAS  Google Scholar 

  47. Ostensen, M. and Husby, G. (1989). Ankylosing spondylitis and pregnancy. Rheum. Dis. Clin. North Am., 15, 241–254.

    PubMed  CAS  Google Scholar 

  48. Ostensen, M., Romberg, O. and Husby, G. (1982). Ankylosing spondylitis and motherhood. Arthritis Rheum., 25, 140–143.

    PubMed  CAS  Google Scholar 

  49. Husby, G., Ostensen, M. and Gran, J. T. (1988). Ankylosing spondylitis and pregnancy. Clin. Exp. Rheumatol, 6, 165–167.

    PubMed  CAS  Google Scholar 

  50. Ostensen, M. (1988). Pregnancy in psoriatic arthritis. Scand. J. Rheumatol, 17, 67–70.

    PubMed  CAS  Google Scholar 

  51. Van der Linden, S. M., Valkenburg, H. A., de Jongh, B. M. and Cats, A. (1984). The risk of developing ankylosing spondylitis in HLA-B27 positive individuals: a comparison of relatives of spondylitis patients with the general population. Arthritis Rheum., 27, 241–249.

    PubMed  Google Scholar 

  52. Van der Linden, S. M. and Khan, M. A. (1984). The risk of ankylosing spondylitis in a HLA-B27 positive individual: A reappraisal. J. Rheumatol., 11, 727–728.

    PubMed  Google Scholar 

  53. Calin, A., Marder, A., Beckss, E. and Burns, T. (1983). Genetic differences between B27 positive patients with ankylosing spondylitis and B27 positive healthy controls. Arthritis Rheum., 26, 1460–1464.

    PubMed  CAS  Google Scholar 

  54. Calin, A. (1984). Comment on Van der Linden article. Arthritis Rheum., 27, 1438.

    PubMed  CAS  Google Scholar 

  55. McHugh, N. and Laurent, M. R. (1986). Psoriatic arthritis and pregnancy. Br. J. Rheumatol, 25(suppl.), 47 (Abstract).

    Google Scholar 

  56. Liang, M. H., Socher, S. A., Roberts, W. N. and Esdaile, J. M. (1988). Measurement of systemic lupus erythematosus activity in clinical research. Arthritis Rheum., 31, 817–825.

    PubMed  CAS  Google Scholar 

  57. Liang, M. H., Socher, S. A., Larson, M. G. and Schur, P. H. (1989). Reliability and validity of six systems for the clinical assessment of disease activity in systemic lupus erythematosus. Arthritis Rheum., 32, 1107–1118.

    PubMed  CAS  Google Scholar 

  58. Lockshin, M. D., Reinitz, E., Druzin, M. L., Murrman, M. and Estes, D. (1984). Lupus pregnancy: case control study demonstrating absence of lupus exacerbation during or after pregnancy. Am. J. Med., 77, 893–898.

    PubMed  CAS  Google Scholar 

  59. Lockshin, M. D. (1989). Pregnancy does not cause systemic lupus erythematosus to worsen. Arthritis Rheum., 32, 665–670.

    PubMed  CAS  Google Scholar 

  60. Lockshin, M. D. and Levy, R. A. (1989). Effect of pregnancy on rheumatic diseases. In Proceedings XVII ILAR Congress of Rheumatology, Rio de Janeiro, Brazil, p. 174.

    Google Scholar 

  61. Gatenby, P. A. (1989). Systemic lupus erythematosus and pregnancy. Aust. N. Z. J. Med., 19, 261–278.

    PubMed  CAS  Google Scholar 

  62. Urowitz, M. B. (1989). Lupus and pregnancy studies. In Proceedings: Second International Conference on Systemic Lupus Erythematosus, Singapore.

    Google Scholar 

  63. Ramsey-Goldman, R. (1988). Pregnancy in systemic lupus erythematosus. Rheum. Dis. Clin. North Am., 14, 169–185.

    PubMed  CAS  Google Scholar 

  64. Mintz, G., Niz, J., Gutierrez, G. et al. (1986). Prospective study of pregnancy in systemic lupus erythematosus. J. Rheumatol, 13, 732–739.

    PubMed  CAS  Google Scholar 

  65. Meehan, R. T. and Dorsey, J. K. (1987). Pregnancy among patients with systemic lupus erythematosus receiving immunosuppressive therapy. J. Rheumatol., 14, 252–258.

    PubMed  CAS  Google Scholar 

  66. Burkett, G. (1989). Lupus nephropathy and pregnancy. Clin. Obstet. Gynecol., 28, 310–323.

    Google Scholar 

  67. Siegall, M., Gwon, N., Lee, S. L., and Wong, W. (1969). Survivorship in systemic lupus erythematosus: relationship to race and pregnancy. Arthritis Rheum., 12, 117–125.

    Google Scholar 

  68. Friedman, E. A. and Rutherford, J. W. (1956). Pregnancy and lupus erythematosus. Obstet. Gynecol., 8, 601–609.

    PubMed  CAS  Google Scholar 

  69. Fraga, A., Mintz, G., Orozco, J. and Orozco, J. H. (1974). Sterility and fertility rates, fetal wastage and maternal morbidity in systemic lupus erythematosus. J. Rheumatol., 1, 293–298.

    Google Scholar 

  70. Tozman, E. C. S., Urowitz, M. D. and Gladman, D. D. (1980). Systemic lupus erythematosus and pregnancy. J. Rheumatol., 7, 624–632.

    PubMed  CAS  Google Scholar 

  71. Estes, D. and Larson, D. L. (1965). Systemic lupus erythematosus and pregnancy. Clin. Obstet. Gynecol, 8, 307–321.

    Google Scholar 

  72. Dubois, E. L. (1974). The clinical picture of systemic lupus erythematosus. In Dubois, E. L. (ed.) Lupus Erythematosus, pp. 324–330, 371-379, 612. (Los Angeles: University of Southern California Press).

    Google Scholar 

  73. Martinez-Cordero, E., Reyes, P. A., Porias, H., Hernandez, A., Romo, J. and Katona, G. (1982). Systemic lupus erythematosus and amenorrhea. Hormonal profile and pathogenic significance. Arthritis Rheum., 25, 581.

    Google Scholar 

  74. Zurier, R. B. (1987). Systemic lupus erythematosus and pregnancy. In Lahita, R. G. (ed.) Systemic Lupus Erythematosus, p. 545 (New York: Wiley).

    Google Scholar 

  75. Lockshin, M. D., Harpel, P. C., Druzin, M. L., Becker, C. G., Klein, R. F., Watson, R. M., Elkon, K. B. and Reinitz, E. (1985). Lupus pregnancy. II. Unusual pattern of hypocomplementemia and thrombocytopenia in the pregnant patient. Arthritis Rheum., 28, 58–66.

    PubMed  CAS  Google Scholar 

  76. Buyon, J. P., Cronstein, B. N., Morris, M., Tanner, M. and Weissman, G. (1986). Serum complement values (C3 and C4) to differentiate between systemic lupus activity and pre-eclampsia. Am. J. Med., 81, 194–200.

    PubMed  CAS  Google Scholar 

  77. Lockshin, M. D., Qamar, T. and Druzin, M. L. (1987). Hazards of lupus pregnancy. J. Rheumatol., 14(suppl. 13), 214–217.

    Google Scholar 

  78. Hayslett, J. P. and Lynn, R. I. (1980). Effect of pregnancy in patients with lupus nephropathy. Kidney Int., 18, 207–220.

    PubMed  CAS  Google Scholar 

  79. Houser, M. T., Fish, A. J., Williams, P. P. and Michael, A. F. (1980). Pregnancy and systemic lupus erythematosus. Am. J. Obstet. Gynecol., 138, 409–413.

    PubMed  CAS  Google Scholar 

  80. Jungers, P., Dougados, M., Pelissier, C., Kuttenn, F., Tron, F. and Lesaure, P. (1982). Lupus nephropathy and pregnancy. Arch. Intern. Med., 142, 771–776.

    PubMed  CAS  Google Scholar 

  81. Mund, A., Simson, J. and Rothfield, N. (1963). Effect of pregnancy on course of systemic lupus erythematosus. J. Am. Med. Assoc, 183, 917–920.

    CAS  Google Scholar 

  82. Grigor, R. R., Shervington, P. C., Hughes, G. R. V. and Hawkins, D. F. (1977). Outcome of pregnancy in system lupus erythematosus. Proc. R. Soc. Med., 70, 99–100.

    PubMed  CAS  Google Scholar 

  83. Chesley, L. C. (1978). Hypertensive Disorders in Pregnancy, pp. 504–508. (New York, Appleton-Century-Crofts).

    Google Scholar 

  84. Mintz, G. and Rodriguez-Alvarez, E. (1989). Systemic lupus erythematosus. Rheum. Dis. Clin. North Am., 15, 255–274.

    PubMed  CAS  Google Scholar 

  85. Fine, L. G., Barnett, E. V., Danovitch, G. M., Nissenson, A. R., Conolly, M. E., Lieb, S. M. and Barrett, C. J. (1981). Systemic lupus erythematosus in pregnancy. Am. Intern. Med., 94, 667–677.

    Google Scholar 

  86. Kistner, R. W. (1971). In Kistner, R. W. (ed.) Gynecology Principles and Practice, 2nd Edn., p. 500. (Chicago: Year Book Medical Publishers).

    Google Scholar 

  87. Abramowsky, C. R., Vegas, M. E., Swinehart, G. and Gyues, M. T. (1980). Decidual vasculopathy of the placenta in lupus erythematosus. N. Engl. J. Med., 303, 668–672.

    PubMed  CAS  Google Scholar 

  88. Dkombroski, R. A. (1989). Autoimmune disease in pregnancy. Med. Clin. North Am., 73, 605–621.

    Google Scholar 

  89. Gimovsky, M. L., Benner, P., Mosntoro, M. et al. (1983). Successful pregnancy in a patient with systemic lupus erythematosus, renal transplantation and chronic renal failure. J. Reprod. Med., 28, 677–680.

    PubMed  CAS  Google Scholar 

  90. Asherson, R. A., Derksen, R. H. W. M., Harris, E. N., Bouma, B. N., Gharavi, A. E., Kater, L. and Hughes, G. R. V. (1987). Chorea in systemic lupus erythematosus and “lupus-like” disease: Association with antiphospholipa antibodies. Semin. Arthritis Rheum., 16, 253–259.

    PubMed  CAS  Google Scholar 

  91. Boey, M. L., Colaco, C. B., Gharavi, A. E., Elkon, K. B., Loizou, S. and Hughes, G. R. V. (1983). Thrombosis in systemic lupus erythematosus: striking association with the presence of circulating lupus anticoagulant. Br. Med. J., 287, 1021–1023.

    CAS  Google Scholar 

  92. Gastineau, D. A., Kazmier, F. J., Nichols, W. L. and Bowie, E. J. (1985). Lupus anticoagulant: An analysis of the clinical and laboratory features of 219 cases. Am. J. Hematol., 19, 265–275.

    PubMed  CAS  Google Scholar 

  93. Much, J. R., Herbst, K. D. and Rappaport, S. I. (1980). Thrombosis in patients with the lupus anticoagulant. Ann. Intern. Med., 92, 156–159.

    Google Scholar 

  94. Hughes, G. R. V. (1983). Thrombosis, abortion, cerebral disease and lupus anticoagulant. Br. Med. J., 287, 1088–1089.

    CAS  Google Scholar 

  95. Eswaran, K. and Rosen, S. W. (1985). Recurrent abortions, thromboses, and a circulating anticoagulant. Am. J. Obstet. Gynecol, 151, 751–752.

    PubMed  CAS  Google Scholar 

  96. Branch, W. D., Scott, J. R., Kochenour, N. K. et al. (1985). Obstetric complications associated with the lupus anticoagulant. N. Engl. J. Med., 313, 1322–1326.

    PubMed  CAS  Google Scholar 

  97. Weinstein, C., Miller, M. H., Axtens, R., Buchanan, R. and Littlejohn, G. O. (1987). Livedo reticularis associated with increased titres of anticardiolipin antibodies in systemic lupus erythematosus. Arch. Dermatol., 123, 596–600.

    PubMed  CAS  Google Scholar 

  98. Kalunian, K. C., Peter, J. B., Middlekauf, H. R., Sayre, J., Ando, D. G., Mangotich, M. and Hahn, B. H. (1988). Clinical significance of a single test for anticardiolipin antibodies in patients with systemic lupus erythematosus. Am. J. Med., 85, 602–608.

    PubMed  CAS  Google Scholar 

  99. Chartash, E. K., Paget, S. A. and Lockshin, M. D. (1986). Lupus anticoagulant associated with aortic and mitral valve insufficiency. Arthritis Rheum., 29, 595 (Abstract).

    Google Scholar 

  100. Khamashta, M. A., Oliver, J. M., Gil, A., Fernando, Z., de Soria, R., Dominquez, F. J. and Vasquez, J. J. (1988). High frequency of subclinical mitral valve dysfunction in patients with SLE: a prospective doppler and echocardiographic study. Br. J. Rheumatol, 27(suppl. 2), 73.

    Google Scholar 

  101. Mackworth-Young, C. G., Loizou, S. and Walport, M J. (1989). Primary antiphospholipid syndrome: features of patients with raised anticardiolipin antibodies and no other disorder. Ann. Rheum. Dis., 48, 362–367.

    PubMed  CAS  Google Scholar 

  102. Alarcon-Segovia, D. (1988). Pathogenetic potential of antiphospholipid antibodies. J. Rheumatol, 15, 890–893.

    PubMed  CAS  Google Scholar 

  103. Lockshin, M. D., Qamar, T., Druzin, M. L. and Goei, S. (1987). Antibody to cardiolipin, lupus anticoagulant and fetal death. J. Rheumatol., 14, 259–262.

    PubMed  CAS  Google Scholar 

  104. Pattison, N. S., McKay, E. J., Liggins, G. C. and Lubbe, W. F. (1987). Anticardiolipin antibodies: their presence as a marker of lupus anticoagulant in pregnancy. N. Z. Med. J., 100, 61–63.

    CAS  Google Scholar 

  105. Lockshin, M. D., Druzin, M. L., Goei, S., Qamar, T., Magid, M. S., Jovanovic, L. and Ferene, M. (1985). Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N. Engl. J. Med., 313, 152–156.

    PubMed  CAS  Google Scholar 

  106. Cronin, M. E., Biswas, R. M., Van der Stracton, C., Fleisher, T. A. and Klippel, J. M. (1988). IgG and IgM anticardiolipin antibodies in patients with lupus with anticardiolipin antibody associated clinical syndromes. J. Rheumatol., 15, 795–798.

    PubMed  CAS  Google Scholar 

  107. Hughes, G. R. V., Harris, E. N. and Gharavi, A. E. (1986). The anticardiolipin syndrome. J. Rheumatol, 13, 486–489.

    PubMed  CAS  Google Scholar 

  108. Harris, E. N., Gharavi, A. E., Patel, S. P. and Hughes, G. R. V. (1987). Evaluation of the anticardiolipin antibody test: report of an international workshop held 4 April 1986. Clin. Exp. Immunol, 68, 215–222.

    PubMed  CAS  Google Scholar 

  109. Petri, M., Rheinschmidt, M. Whiting-O’Keefe, Q., Hellman, D. and Corash, L. (1987). The frequency of lupus anticoagulant in systemic lupus erythematosus: a study of 60 consecutive patients by activated partial thromboplastin time, Russell viper venom time, and anticardiolipin antibody level. Ann. Intern. Med., 106, 524–530.

    PubMed  CAS  Google Scholar 

  110. Lechner, K. (1987). Lupus anticoagulants and thrombosis. In Verstraete, M., Vermylen, J., Lijneu, R. and Arnaut, J. (eds.) Thrombosis and Hemostasis, pp. 525–547 (Leuven: International Society on Thrombosis and Hemostasis and Leuven, University Press).

    Google Scholar 

  111. Lockshin, M. D. (1989). Anticardiolipin antibodies and pregnancy. Proceedings XVII ILAR Congress of Rheumatology, Rio de Janeiro, Brazil, pp. 43–45.

    Google Scholar 

  112. Petri, M., Golbus, M., Anderson, R., Whiting-O’Keefe, Q. Corash, L. and Hellman, D. (1987). Antinuclear antibody, lupus anticoagulant, and anticardiolipin antibody in women with idiopathic habitual abortions. Arthritis Rheum., 30, 601–606.

    PubMed  CAS  Google Scholar 

  113. Cowchock, S., Fort, J., Munoz, S., Norberg, R. and Maddrey, W. (1988). False positive ELISA tests for anticardiolipin antibodies in sera from patients with repeated abortion, rheumatologic disorders and primary biliary cirrhosis: correlation with elevated polyclonal IgM and implications for patients with repeated abortion. Clin. Exp. Immunol, 73, 289–294.

    PubMed  CAS  Google Scholar 

  114. Hughes, G. R. V., Asherson, R. A. and Khamashta, M. A. (1989). Antiphospholipid syndrome: linking many specialties. Ann. Rheum. Dis., 48, 355–356.

    PubMed  CAS  Google Scholar 

  115. Lubbe, W. F. and Liggins, G. C. (1985). Lupus anticoagulant and pregnancy. Am. J. Obstet. Gynecol., 153, 322–327.

    PubMed  CAS  Google Scholar 

  116. Branch, D., Scott, J., Kochenaur, N. and Hershgold, E. (1985). Obstetric complications associated with the lupus anticoagulant. N. Engl J. Med., 313, 1322–1326.

    PubMed  CAS  Google Scholar 

  117. Hanly, J. G., Gladman, D. D., Rose, T. H., Laskin, C. A. and Urowitz, M. B. (1988). Lupus pregnancy. A prospective study of placental changes. Arthritis Rheum., 31, 358–366.

    PubMed  CAS  Google Scholar 

  118. Stafford-Brady, F. J., Gladman, D. D. and Urowitz, M. B. (1988). Successful pregnancy in systemic lupus erythematosus with an untreated lupus anticoagulant. Arch. Intern. Med., 148, 1647–1648.

    PubMed  CAS  Google Scholar 

  119. Trudinger, B. J., Stewart, G. J., Cook, C. M., Connelly, A. and Exner, T. (1988). Monitoring lupus anticoagulant-positive pregnancies with umbilical artery flow velocity waveforms. Obstet. Gynecol., 72, 215–218.

    PubMed  CAS  Google Scholar 

  120. Harris, E. N. (1988).Third International Antiphospolipid Conference: barbecues, rum punches, and kaps. Ann. Rheum. Dis., 47, 612–614.

    Google Scholar 

  121. Walport, M. J. (1989). Pregnancy and antibodies to phospholipids. Ann. Rheum. Dis., 48, 795–797.

    PubMed  CAS  Google Scholar 

  122. Petri, M., Watson, R. and Hochberg, M. L. (1989). Anti-Ro antibodies and neonatal lupus. Rheum. Dis. Clin. North Am., 15, 335–360.

    PubMed  CAS  Google Scholar 

  123. Provost, T. T., Watson, R., Garther, K. K. and Harley, J. B. (1987). The neonatal lupus erythematosus syndrome. J. Rheumatol, 14, 199–207.

    Google Scholar 

  124. Lockshin, M. D., Bonfa, E., Elkon, K. and Druzin, M. L. (1988). Neonatal risk to newborns of mothers with systemic lupus erythematosus. Arthritis Rheum., 31, 697–701.

    PubMed  CAS  Google Scholar 

  125. Buyon, J. P., Sweisky, S. H., Fox, H. E., Bierman, F. Z. and Winchester, R. J. (1987). Intrauterine therapy for presumptive fetal myocarditis with acquired heart block due to systemic lupus erythematosus. Arthritis Rheum., 30, 44–49.

    PubMed  CAS  Google Scholar 

  126. Taylor, P. V., Taylor, K. F., Norman, A., Griffiths, S. and Scott, J. S. (1988). Prevalence of maternal Ro (SS-A) and La (SS-B) autoantibodies in relation to congenital heart block. Br. J. Rheumatol., 27, 128–132.

    PubMed  CAS  Google Scholar 

  127. Provost, T. T., Watson, R. M., Gammon, W. R., Radowsky, M., Harley, J. B. and Reichlin, M. (1987). The neonatal lupus syndrome associated with Ul RNP (nRNP) antibodies. N. Engl. J. Med., 316, 1135–1138.

    PubMed  CAS  Google Scholar 

  128. Ramsey-Goldman, R., Horn, D., Deng, J. S., Ziegler, G. C., Kahl, L. E., Steen, V. D., La Porte, R. E. and Medsger, J. A. (1986). Anti-SS-A antibodies and fetal outcome in maternal systemic lupus erythematosus. Arthritis Rheum., 29, 1269–1273.

    PubMed  CAS  Google Scholar 

  129. Michaelsson, M. and Engle, M. A. (1972). Congenital complete heart block: An international study of the natural history. Cardiovasc. Clin., 4, 85–101.

    PubMed  CAS  Google Scholar 

  130. McCune, A. B., Weston, W. L. and Lee, L. A. (1987). Maternal and fetal outcome in neonatal lupus erythematosus. Ann. Intern. Med., 106, 518–523.

    PubMed  CAS  Google Scholar 

  131. Esscher, E. and Scott, J. S. (1979). Congenital heart block and maternal systemic lupus erythematosus. Br. Med. J., 1, 1235–1238.

    PubMed  CAS  Google Scholar 

  132. Harley, J. B., Kaine, J. L., Fox, O. F., Reichlin, M. and Gruber, B. (1985). Ro (SS-A) antibody and antigen in a patient with congenital complete heart block. Arthritis Rheum., 28, 1321–1325.

    PubMed  CAS  Google Scholar 

  133. Callen, J. P., Fowler, J. F., Kulick, K. B., Stelzer, G. and Smith, S. Z. (1985). Neonatal lupus erythematosus occurring in one fraternal twin: serologic and immunogenetic studies. Arthritis Rheum., 28, 271–275.

    PubMed  CAS  Google Scholar 

  134. Scott, J. S., Maddison, P. J., Taylor, P. V., Esscher, E., Scott, O. and Skinner, R. P. (1983). Connective tissue disease, antibodies to ribonucleoprotein and congenital heart block. N. Engl. J. Med., 309, 209–212.

    PubMed  CAS  Google Scholar 

  135. McNicholl, J. M., Provost, T. T., Bias, W.-B., Harley, J. B., Reichlin, M. and Alexander, E. L. (1988). Immunogenic relationship between anti-Ro (SS-A) positive Sjogrens syndrome/lupus erythematosus patients and mothers of infants with neonatal lupus erythematosus. Arthritis Rheum., 31, 594.

    Google Scholar 

  136. Kasinath, B. S. and Katz, A. I. (1982). Delayed maternal lupus after delivery of offspring with congenital heart block. Arch. Intern. Med., 142, 2317.

    PubMed  CAS  Google Scholar 

  137. Lockshin, M. D., Harpel, P. C., Druzin, M. C., Becker, C. G., Klein, R. F., Watson, R. M., Elkon, K. B. and Reinitz, E. (1985). Lupus pregnancy. II. Unusual pattern of hypocomplementemia and thrombocytopenia in the pregnant patient. Arthritis Rheum., 28, 58–66.

    PubMed  CAS  Google Scholar 

  138. Watson, R. M., Lane, A. T., Barnett, N. K., Bias, W. B., Arnett, F. C. and Provost, T. T. (1984). Neonatal lupus erythematosus. A clinical, serological and immunogenetic study with review of the literature. Medicine (Baltimore), 63, 362–378.

    CAS  Google Scholar 

  139. Maddison, P. J. (1988). The neonatal lupus syndrome. Clin. Exp. Rheumatol., 6, 173–178.

    Google Scholar 

  140. Reid, J. M., Coleman, E. N. and Doig, W. (1982). Complete congenital heart block. Report of 35 cases. Br. Heart J., 48, 236–240.

    PubMed  CAS  Google Scholar 

  141. McCune, C. M., Mantakas, M. E., Tingelstad, J. B. and Ruddy, S. (1977). Congenital heart block in newborn of mothers with connective tissue disease. Circulation, 56, 82–90.

    Google Scholar 

  142. Lanham, J. G., Walport, M. J. and Hughes, G. R. V. (1983). Congenital heart block and familial connective tissue disease. J. Rheumatol., 10, 823–825.

    PubMed  CAS  Google Scholar 

  143. Waterworth, R. F. (1980). Systemic lupus erythematosus occurring with congenital complete heart block. N. Z. Med. J., 92, 311–312.

    PubMed  CAS  Google Scholar 

  144. Brustein, D., Rodriquez, J. M. and Minkin, F. (1977). Familial lupus erythematosus. J. Am. Med. Assoc., 238, 2294.

    CAS  Google Scholar 

  145. Jackson, R. and Gulliver, M. (1979). Neonatal lupus erythematosus progressing into systemic lupus erythematosus: a 15 year follow-up. Br. J. Dermatol., 101, 81–86.

    PubMed  CAS  Google Scholar 

  146. Fox, J. R., McCuistion, C. H. and Schooch, E. P. (1979). Systemic lupus erythematosus: association with previous neonatal lupus erythematosus. Arch. Dermatol., 115, 340.

    PubMed  Google Scholar 

  147. Kaufman, R. L. and Kitridou, R. C. (1982). Pregnancy in mixed connective tissue disease: comparison with systemic lupus erythematosus. J. Rheumatol., 9, 549–555.

    PubMed  CAS  Google Scholar 

  148. Bennett, R. M. and O’Connell, D. (1980). Mixed connective tissue disease: a clinicopathologic study of 20 cases. Semin. Arthritis Rheum., 10, 25–31.

    PubMed  CAS  Google Scholar 

  149. Kitridou, R. C. (1988). Pregnancy in mixed connective tissue disease, polydermatomyositis and scleroderma. Clin. Exp. Rheumatol, 6, 173–178.

    PubMed  CAS  Google Scholar 

  150. Provost, T. T., Watson, R., Gammon, W. R., Radowsky, M., Harley, J. B. and Reichkin, M. (1987). The neonatal lupus syndrome associated with U. RNP (nRNP) antibodies. N. Engl. J. Med., 316, 1135–1138.

    PubMed  CAS  Google Scholar 

  151. Giordino, M., Valentini, G., Lupolis, S. and Giordano, A. (1985). Pregnancy and systemic sclerosis. Arthritis Rheum., 28, 237–238.

    Google Scholar 

  152. Silman, A. J. and Black, C. (1988). Increased incidence of spontaneous abortion and infertility in women with scleroderma before disease onset: a controlled study. Ann. Rheum. Dis., 47, 441–444.

    PubMed  CAS  Google Scholar 

  153. Steen, V. D., Conte, C., Day, N., Ramsey-Goldman, R. and Medsger, T. A. (1989). Pregnancy in women with systemic sclerosis. Arthritis Rheum., 32, 151–157.

    PubMed  CAS  Google Scholar 

  154. Ballou, S. P., Morley, J. J. and Kashnor, I. (1984). Pregnancy and systemic sclerosis. Arthritis Rheum., 27, 295–298.

    PubMed  CAS  Google Scholar 

  155. Englert, H., Black, C. M. and Silman, A. (1988). Pregnancy outcome in patients with scleroderma. Br. J. Rheumatol., 27(abs. suppl. 2), 75.

    Google Scholar 

  156. Stevener, M. A. and Ng, A. B. P. (1970). Scleroderma of the uterine cervix. Am. J. Obstet. Gynecol., 107, 965–966.

    Google Scholar 

  157. Johnson, T. R., Banner, E. A. and Winkelmann, R. K. (1964). Scleroderma and pregnancy. Obstet. Gynecol., 23, 467–469.

    PubMed  CAS  Google Scholar 

  158. Scarpinato, L. and MacKenzie, A. H. (1985). Pregnancy and systemic sclerosis: case report and review of the literature. Cleve. Clin. Q., 52, 207–211.

    PubMed  CAS  Google Scholar 

  159. Black, C. M. and Stevens, W. M. (1989). Scleroderma. Rheum. Dis. Clin. North Am., 15, 193–212.

    PubMed  CAS  Google Scholar 

  160. Bellamy, N. and Dewar, C. L. (1990). Relapsing polychondritis in pregnancy. J. Rheumatol. (in press).

    Google Scholar 

  161. Voitk, A. J., Mueller, J. C., Farlinger, D. E. and Johnston, R. V. (1987). Carpal tunnel syndrome in pregnancy. Can. Med. Assoc. J., 128, 277–281.

    Google Scholar 

  162. McLennan, G., Oats, J. N. and Walstab, J. E. (1987). Survey of hand symptoms in pregnancy. Med. J. Aust., 147, 542–544.

    PubMed  CAS  Google Scholar 

  163. Melvin, J. L., Burnett, C. N. and Johnson, E. W. (1969). Median nerve conduction in pregnancy. Arch. Phys, Med. L., 50, 75–80.

    CAS  Google Scholar 

  164. Tobin, S. M. (1967). Carpal tunnel syndrome in pregnancy. Am. J. Obstet. Gynecol, 97, 493–498.

    PubMed  CAS  Google Scholar 

  165. Golding, D. N. (1982). Some problems of backache in women. In Hill A. G. S. (ed.) Topical Reviews in Rheumatic Disorders, pp. 203–213. (Bristol: John Wright and Sons).

    Google Scholar 

  166. Mantle, M. J., Greenwood, R. M. and Currey, H. L. F. (1977). Backache in pregnancy. Rheumatol Rehabil., 16(2), 95–101.

    PubMed  CAS  Google Scholar 

  167. O’Brien, J. P., Goldenberg, D. L. and Rice, P. A. (1983). Disseminated gonococcal infection: a prospective analysis of 49 patients and a review of pathophysiology and immune mechanisms. Medicine, 62, 395–406.

    PubMed  Google Scholar 

  168. Taylor, H. A., Bradford, S. A. and Patterson, S. P. (1966). Gonococcal arthritis in pregnancy. Obstet. Gynecol., 27, 776–782.

    PubMed  CAS  Google Scholar 

  169. Eisenstein, B. I. and Masi, A. T. (1981). Disseminated gonococcal infection (DGI) and gonococcal arthritis (GCA): I. Bacteriology, epidemiology, host factors, pathogen factors, and pathology. Semin. Arthritis Rheum., 10(3), 155–172.

    PubMed  CAS  Google Scholar 

  170. Roubenoff, R., Hoyt, J., Pétri, M. et al (1988). Effects of anti-inflammatory and immunospressive drugs on pregnancy and fatality. Semin. Arthritis Rheum., 18(2), 88–110.

    PubMed  CAS  Google Scholar 

  171. Rustin, G. J., Both, M., Dent, J. et al. (1984). Pregnancy after cytotoxic chemotherapy for gestational trophoblastic tumours. Br. Med. J., 288, 103–105.

    CAS  Google Scholar 

  172. Warne, G. L., Farley, K. F., Hobbs, J. B. et al. (1973). Cyclophosphamide-induced ovarian failure. N. Engl. J. Med., 289, 1159–1162.

    PubMed  CAS  Google Scholar 

  173. Uldall, P. R., Kerr, D. N. S. and Tacchi, D. (1972). Sterility and cyclophosphamide. Lancet, 1, 693–694.

    PubMed  CAS  Google Scholar 

  174. Kumar, R., McEvoy, J., Biggart, J. D. et al. (1972). Cyclophosphamide and reproductive function. Lancet, 1, 1212–1214.

    PubMed  CAS  Google Scholar 

  175. Kayama, H., Wada, T., Nishizawa, Y. et al. (1977). Cyclophosphamide-induced ovarian failure and its therapeutic significance with patients with breast cancer. Cancer, 39, 1403–1409.

    Google Scholar 

  176. Ostensen, M. and Husby, G. (1985). Anti-rheumatic drug treatment during pregnancy and lactation. Scand. J. Rheumatol., 14, 1–7.

    PubMed  CAS  Google Scholar 

  177. Brooks, P. M. and Needs, C. J. (1989). The use of antirheumatic medication during pregnancy and in the puerperium. Rheum. Dis. Clin. North Am., 15(4), 789–806.

    PubMed  CAS  Google Scholar 

  178. Boissel, J. P., Blanchard, J., Panak, E. et al. (1989). Considerations for the meta-analysis of randomized clinical trials. Controlled Clinical Trials, 10, 254–281.

    PubMed  CAS  Google Scholar 

  179. Sackett, D. L. (1979). Bias in analytic research. J. Chronic Dis., 32, 51–63.

    PubMed  CAS  Google Scholar 

  180. Slone, D., Heinonen, O. P., Kaufman, D. W. et al. (1976). Aspirin and congenital malformations. Lancet, 1, 1373–1375.

    PubMed  CAS  Google Scholar 

  181. Dudley, D. K. L. and Hardie, M. J. (1985). Fetal and neonatal affects of indomethacin as a tocolytic agent. Am. J. Obstet. Gynecol., 151, 181–184.

    PubMed  CAS  Google Scholar 

  182. Niebyl, J. R. and Witter, F. R. (1986). Neonatal outcome after indomethacin treatment for preterm labour. Am. J. Obstet. Gynecol, 155, 747–749.

    PubMed  CAS  Google Scholar 

  183. Wilkinson, A. R., Aynsley-Green, A. and Mitchell, M. D. (1971). Persistent pulmonary hypertension and abnormal prostaglandin E levels in preterm infants after maternal treatment with naproxen. Arch. Dis. Child., 54, 942–945.

    Google Scholar 

  184. Wilkinson, A. R. (1980). Naproxen levels in preterm infants after maternal treatment. Lancet, 2, 591–592.

    PubMed  CAS  Google Scholar 

  185. Alun-Jones, E., Williams, J. and Clwyd, G. (1986). Hyponatremia and fluid retention in a neonatal associated with maternal naproxen overdosage. Clin. Toxicol, 24, 257–260.

    CAS  Google Scholar 

  186. Bongiovanni, A. M and McPadden, A. J. (1960). Steroids during pregnancy and possible fetal consequences. Fertil Steril, 11(2), 181–186.

    PubMed  CAS  Google Scholar 

  187. Serment, M. M. H., Charpin, J., Tessier, G. et al. (1968). Corticotherapie et grossesse. Bull Fed. Soc. Gynecol. Langue Française, 20, 159–161.

    Google Scholar 

  188. Jefferies, W. M. and Levy, R. P. (1959). Treatment of ovarian dysfunction with small doses of cortisone or hydrocortisone. J. Clin. Endocrinol. Metab., 19, 1069–1080.

    PubMed  CAS  Google Scholar 

  189. Walsh, S. D. and Clark, F. R. (1967). Pregnancy in patient on long term cortico-steroids therapy. Scott. Med. J., 12, 302–306.

    PubMed  CAS  Google Scholar 

  190. Oakey, R. E. (1970). The interpretation of urinary estrogen and pregnanediol excretion in pregnant women receiving corticosteroids. J. Obstet. Gynecol, 77, 922–927.

    CAS  Google Scholar 

  191. Schatz, M., Patterson, R., Zeitz, S. et al. (1975). Corticosteroid therapy for the pregnant asthmatic patient. J. Am. Med. Assoc, 233, 804–807.

    CAS  Google Scholar 

  192. Taeusch, H. W., Frigoletto, F., Kitzmiller, J. J. et al (1979). Risk of respiratory distress syndrome after prenatal dexamethasone treatment. Paediatrics, 63, 64–72.

    Google Scholar 

  193. Collaborative Group on Antenatal Steroid Therapy (1981). Effect of antenatal dexamethasone administration on the prevention of respiratory distress syndrome. Am. J. Obstet. Gynecol, 141, 276–286.

    Google Scholar 

  194. Yackel, D. B., Kempers, R. D. and McConahey, W. M. (1966). Adrenocorticosteroid therapy in pregnancy. Am. J. Obstet. Gynecol, 96, 985–989.

    PubMed  CAS  Google Scholar 

  195. Reinsch, J. M. and Simon, M. J. (1978). Prenatal exposure to prednisone in humans and animals retards intrauterine growth. Science, 202, 436–438.

    Google Scholar 

  196. Oppenheimer, E. H. (1964). Lesions in the adrenals of an infant following maternal corticosteroid therapy. Bull. Johns Hopkins Hosp., 114, 146–151.

    PubMed  CAS  Google Scholar 

  197. Taeusch, H. W., Kamali, H., Hehre, A. et al. (1977). Dexamethasone and its effect on adrenal function in prematures. Pediatr. Res., 11, 432.

    Google Scholar 

  198. Lyle, W. H. (1978). Penicillamine in pregnancy. Lancet, 1, 606–607.

    PubMed  CAS  Google Scholar 

  199. Mjolnerod, O.-K., Rasmussen, K., Dommerud, S. A. et al (1971). Congenital connective-tissue defect probably due to D-penicillamine treatment in pregnancy. Lancet, 1, 673–674.

    PubMed  CAS  Google Scholar 

  200. Solomon, L., Abrams, G. Dinneser, M. et al. (1977). Neonatal abnormalities associated with D-penicillamine treatment during pregnancy. N. Engl. J. Med., 296, 54–55.

    PubMed  CAS  Google Scholar 

  201. Lenares, A., Zarrazz, J. J., Rodriquez-Alarcon, J. et al. (1977). Reversible cutis laxa due to maternal D-penicillamine treatment. Lancet, 2, 43.

    Google Scholar 

  202. Harpey, J. P., Jaudon, M. C., Clavel, J. P. et al. (1983). Cutis laxa and low serum zinc after antenatal exposure to penicillamine. Lancet, 2, 144–145.

    Google Scholar 

  203. Endres, W. (1981). D-Penicillamine in pregnancy — to ban or not to ban. Med. Klin. Wochenschr., 59, 535–537.

    CAS  Google Scholar 

  204. Neel, W. A., Panaye, G. S., Duthie, J. J. R. et al. (1973). Action of chloroquine phosphate in rheumatoid arthritis. II. Chromosone damaging effect. Ann. Rheum. Dis., 32, 547–550.

    Google Scholar 

  205. Ullberg, S., Lindquist, N. J. and Sjostrand, S. E. (1970). Accumulation of chororetinotoxic drugs in the fetal eye. Nature, 227, 1257–1258.

    PubMed  CAS  Google Scholar 

  206. Merwin, C. F. and Winkelmann, R. K. (1962). Anti-malarial drugs in the therapy of lupus erythematosus. Mayo Clin. Proc, 37, 253–268.

    CAS  Google Scholar 

  207. Dziubinski, E. H., Winkelmann, R. K. and Wilson, R. B. (1962). Systemic lupus erythematosus and pregnancy. Am. J. Obstet. Gynecol., 84, 1873–1877.

    Google Scholar 

  208. Stone, C. T. (1962). Antimalarial drugs in the treatment of rheumatoid arthritis. Tex. J. Med., 58, 809.

    Google Scholar 

  209. Fraga, A., Mintz, G., Orozco, J. and Orozco, J. H. (1974). Sterility and fertility rates, fetal wastage and maternal morbidity in systemic lupus erythematosus. J. Rheumatol., 1, 293–298.

    Google Scholar 

  210. Park, A. L. (1988). Antimalarial drugs, systemic lupus erythematosus and pregnancy. J. Rheumatol., 15, 607–610.

    Google Scholar 

  211. Ostensen, M. (1983). Piroxicam in human breast milk. Eur. J. Clin. Pharmacol, 25, 829.

    PubMed  CAS  Google Scholar 

  212. Eeg-Olofsson, O., Malmros, I., Elwin, C. E. et al (1978). Convulsions in a breast-fed infant after maternal indomethacin. Lancet, 2, 215.

    PubMed  CAS  Google Scholar 

  213. Wiernik, P. H. and Duncan, J. H. (1971). Cyclophosphamide in human milk. Lancet, 1, 912.

    PubMed  CAS  Google Scholar 

  214. Blau, S. P. (1973). Metabolism of gold during lactation. Arthritis Rheum., 16, 777–778.

    PubMed  CAS  Google Scholar 

  215. Merland, R. and Creste, M. (1951). Study of the elimination and estimation of nivaquine in human milk. Med. Trop., 11, 793–795.

    CAS  Google Scholar 

  216. Anderson, P. O. (1977). Drugs and breast feeding — a review. Drug Int. Clin. Pharm., 11, 208–223.

    CAS  Google Scholar 

  217. Johns, D. G., Rutherford, L. D., Leighton, P. C. et al (1972). Secretion of methotrexate into human milk. Am. J. Obstet. Gynecol., 112, 978–980.

    PubMed  CAS  Google Scholar 

  218. Esbjorner, E., Jarnerot, G. and Wranne, L. (1986). Sulphasalazine and sulphapyridine levels in children of mothers treated with sulphasalazine during pregnancy and lactation. Acta Paediatr. Scand., 76, 137–142

    Google Scholar 

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Bellamy, N., Grigor, R.R., Naden, R.P. (1991). Arthritis in pregnancy. In: Bellamy, N. (eds) Prognosis in the Rheumatic Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3896-3_14

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