Abstract
Anti-inflammatory medications, including indomethacin, are commonly used perioperatively in patients undergoing total joint reconstruction as well as skeletal repair following trauma. In this study we compared the effects of several pre-operative indomethacin withdrawal regimes upon the early biomechanical performance of porous CoCr beaded cylinders and AO/ASIF screws in bone utilizing a canine model. Chronic indomethacin given at a dose of 0.5mg/kg/day for 10 weeks prior to surgery and 6 weeks following surgery caused a 20% reduction in interface strength at 6 weeks. By withholding (interrupting) the indomethacin therapy for 3-5 weeks prior to surgery, the resultant interface strengths of the transcortical porous implants were the same as an untreated control group at 6 weeks post-operatively. Cortical and cancellous screw pullout strengths at 6 weeks post-implantation were not affected by chronic indomethacin therapy in this experimental model.
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© 1991 Elsevier Science Publishers Ltd
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Longo, J.A., Magee, F.P., Poser, R.D. (1991). Chronic Indomethacin Therapy and the Interfaces of Screws and Porous Implants in Bone. In: Williams, K.R., Toni, A., Middleton, J., Pallotti, G. (eds) Interfaces in Medicine and Mechanics—2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3852-9_49
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DOI: https://doi.org/10.1007/978-94-011-3852-9_49
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-85166-583-9
Online ISBN: 978-94-011-3852-9
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