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Interfaces in Medicine and Mechanics—2 pp 430–434Cite as

Growth Hormone Stimulates Osteoid Formation at a Bone-Ceramic Interface

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Abstract

Tri-calcium phosphate (TCP) ceramic pins have been loaded with human growth hormone (GH) and inserted into rabbit femora. A new method for processing bone with biomaterial implants has enabled histomorphometric analysis of the tissue response to insertion of the TCP pins at an intact interface.

This in vivo study demonstrates that loading TCP ceramic with human growth hormone significantly increases the percentage of osteoid tissue that forms on the bone surface adjacent to the ceramic, when compared to a normal bone-ceramic interface. We propose that growth hormone stimulation of early osteoid formation at the interface could lead to increased remodelling of bone and improve the success rate of implantation of ceramic coated prostheses.

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References

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Author information

Authors and Affiliations

  1. Institute of Orthopaedics (U.C.L.), Stanmore, Middx., HA7 4LP, England

    Rachel Hann, Mike Kayser & Sandra Downes

  2. Biomaterials Research Group, Dept. of Biomaterials, Leiden University, School of Medicine, Leiden, Holland

    Christel Klein

Authors
  1. Rachel Hann
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  2. Mike Kayser
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  3. Christel Klein
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  4. Sandra Downes
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Editor information

Editors and Affiliations

  1. Department of Basic Dental Science, University of Wales College of Medicine, Cardiff, UK

    K. R. Williams

  2. Orthopaedic Clinic, University of Bologna, Italy

    A. Toni

  3. Department of Civil Engineering, University College of Swansea, UK

    J. Middleton

  4. University of Bologna, Italy

    G. Pallotti

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© 1991 Elsevier Science Publishers Ltd

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Hann, R., Kayser, M., Klein, C., Downes, S. (1991). Growth Hormone Stimulates Osteoid Formation at a Bone-Ceramic Interface. In: Williams, K.R., Toni, A., Middleton, J., Pallotti, G. (eds) Interfaces in Medicine and Mechanics—2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3852-9_46

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  • DOI: https://doi.org/10.1007/978-94-011-3852-9_46

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-85166-583-9

  • Online ISBN: 978-94-011-3852-9

  • eBook Packages: Springer Book Archive

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