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Formation of Extracellular Deposits by Macrophages Exposed to Poorly Degradable Biomaterials

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Interfaces in Medicine and Mechanics—2

Abstract

Foreign-body granulomas formed in reaction to the intraperitoneal injection of suspensions containing granulated calcium phosphates or crocidolite asbestos fibers were studied with transmission electron microscopy and X-ray microanalysis. It was found that the structure of the granulomas was dependent on the nature of the injected material. Macrophages found in the granulomas contained iron-rich inclusion bodies. Asbestos bodies were plentiful in the crocidolite asbestos-stimulated animals. Structures similar to asbestos bodies were also detected in the tri-calcium phosphate stimulated animals and in smaller numbers in the hydroxyapatite-stimulated animals. Like the results of our studies on the mechanism of asbestos body formation [1,2] the present findings show that macrophages encountering relatively large, poorly digestible particles are triggered to exocytose their lysosomal contents into a micro-environment formed between cells and material.

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Author information

Authors and Affiliations

  1. Biomaterials Research Group, Laboratory for Electron Microscopy, University of Leiden, Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    H. K. Koerten, C. A. Van Blitterswuk, S. C. Hesseling, J. D. De Bruijn, J. J. Grote & W. TH. Daems

Authors
  1. H. K. Koerten
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  2. C. A. Van Blitterswuk
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  3. S. C. Hesseling
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  4. J. D. De Bruijn
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  5. J. J. Grote
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  6. W. TH. Daems
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Editor information

Editors and Affiliations

  1. Department of Basic Dental Science, University of Wales College of Medicine, Cardiff, UK

    K. R. Williams

  2. Orthopaedic Clinic, University of Bologna, Italy

    A. Toni

  3. Department of Civil Engineering, University College of Swansea, UK

    J. Middleton

  4. University of Bologna, Italy

    G. Pallotti

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© 1991 Elsevier Science Publishers Ltd

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Koerten, H.K., Van Blitterswuk, C.A., Hesseling, S.C., De Bruijn, J.D., Grote, J.J., Daems, W.T. (1991). Formation of Extracellular Deposits by Macrophages Exposed to Poorly Degradable Biomaterials. In: Williams, K.R., Toni, A., Middleton, J., Pallotti, G. (eds) Interfaces in Medicine and Mechanics—2. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3852-9_16

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  • DOI: https://doi.org/10.1007/978-94-011-3852-9_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-85166-583-9

  • Online ISBN: 978-94-011-3852-9

  • eBook Packages: Springer Book Archive

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