Abstract
After a short review of the history of pituitary growth hormone the effects of the availability of biosynthetic growth hormone are described. Possible benefits, particularly the hope to relieve some of the distress of short children, are weighed against possible risks, a.o. the uncertainties about effects and side-effects and the high cost. Under these circumstances we have chosen for a strategy of concerted action by the medical professionals directly envolved: well-planned prospective long-term studies and thorough retrospective analysis.
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References
Wit, J.M. (1986) ‘Responses to growth hormone’. Academic Thesis. State University, Utrecht.
Spiliotis, B.E., August, G.P., Hung, W. et al. (1984) ‘Growth hormone neurosecretory dysfunction. A treatable cause of short stature’. JAMA 251, 2223–2230.
Rose, S.R., Ross, J.L., Uriarte, M.U. et al (1988) ‘The advantage of measuring stimulated as compared with spontaneous growth hormone levels in the diagnosis of growth hormone deficiency’. N Engl J Med 319, 201–207.
Kastrup, K.W., Christiansen, J.S., Anderson, J.K. et al. (1983) ‘Increased growth rate following transfer to daily sc administration from three weekly im injections of hGH in growth hormone deficient children’. Acta Endocrinol (Copenh) 104, 148–152.
Jorgensen, J.O.L., Flyvbjerg, A., Lauritzen, T. et al. ‘Dose-response studies with biosynthetic human growth hormone (GH) in GH-deficient patients’. (1988) J Clin Endocrinol Metab 67, 36–40.
Brown, P. (1988) ‘Human growth hormone therapy and CreutzfeldtJakob Disease: A drama in three acts’. Pediatrics 81, 85–92.
Seeburg, P.H., Shine, J., Martial, J.A. et al. (1978) ‘Synthesis of growth hormone by bacteria’. Nature 276, 795–798.
Rosenfeld, R.G., Hintz, R.L., Johanson, A.J. et al. (1988) Three year results of a randomized prospective trial of methionyl human growth hormone and oxandrolone in Turner syndrome. J Pediatr 113, 393–400.
Rongen-Westerlaken, C., Fokker, M.H., Wit, J.M. et al (1990) ‘Two year results of treatment with methionyl human growth hormone in girls with Turner syndrome’. Acta Paediatr Scand, in press.
Wit, J.M., Fokker, M.H., de Muinck Keizer Schrama, S.M.P.F. et al (1989) ‘Effects of two years of methionyl growth hormone therapy in two dosage regimens in prepubertal children with short stature, subnormal growth rate and normal growth hormone response to secretagogues’. J Pediatr. 115, 720–725.
Koch, V.H., Lippe, B.M., Nelson, P.A. et al (1989) ‘Accelerated growth after recombinant human growth hormone treatment of children with chronic renal failure’. J Pediatr 115, 365–371.
De Muinck Keizer-Schrama, S.M.P.F., Hokken-Koelega, A.C.S., Drop, S.L.S. et al. (1989) ‘Dose-response study with biosynthetic growth hormone (GH) in growth hormone deficient (GHD) children’. Hormone Research, 3151;34.
Jorgensen, J.O.L., Thuesen, L., Ingemann-Hansen, T. et al (1989) ‘Beneficial effects of growth hormone treatment in GH-deficient adults’. The Lancet 1, 1221–1224.
Binnerts, A., Wilson, J.H., Lamberts, S.W. (1988) ‘The effects of human growth hormone administration in elderly adults with recent weight loss’. J Clin Endocrinol Metab 67, 1312–1316.
Lantos, J., Siegler, M., Cuttler, L. (1989) ‘Ethical issues in growth hormone therapy’. JAMA 261, 1020–1024.
Law, C.M. (1987) ‘The disability of short stature’. Arch Dis Child. 62, 855–859.
Wit, J.M., Hughes, M.J. (1988) ‘Development of a software program providing a data-base and enabling mathematical handling and graphical presentation of growth data’. Pediatric Research 24, 528.
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© 1990 Springer Science+Business Media Dordrecht
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Wit, J.M. (1990). Experience with Biosynthetic Growth Hormone. In: Crommelin, D.J.A., Schellekens, H. (eds) From Clone to Clinic. Developments in Biotherapy, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3780-5_29
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DOI: https://doi.org/10.1007/978-94-011-3780-5_29
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5683-0
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