Summary
A laser balloon catheter/delivery system has been developed to test the hypotheses that the combination of appropriate levels of heat and pressure during balloon inflation will improve luminal dimensions and morphology to a greater extent than the application of pressure alone as well as mitigate adverse biologic responses to mechanical injury. Experimentally, the conditions under which fusion of separated tissue layers of the atheromatous arterial wall can be achieved have been defined, and proposed beneficial effects on arterial recoil and intraluminal thrombus have been demonstrated. Recent clinical studies suggest that LBA improves coronary luminal dimensions over those achievable with initial PTC A by these mechanisms. Improved laser diffusing tip technology and continued laser dosimetry studies will be required to determine whether adverse biologic responses can be reduced by LBA.
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Spears, J.R. (1991). Laser Balloon Angioplasty (LBA). In: Reiber, J.H.C., Serruys, P.W. (eds) Quantitative Coronary Arteriography. Developments in Cardiovascular Medicine, vol 117. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3726-3_16
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DOI: https://doi.org/10.1007/978-94-011-3726-3_16
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