Abstract
The three-dimensional arrangements of molecular fragments that may or may not lead to molecular chirality are subject to quantum mechanical uncertainty and to a more significant uncertainty due to the non-rigid nature of molecules. Molecular chirality is an energy dependent property: if sufficient energy is available, then no molecule can retain its chiral properties since rearrangement and decomposition reactions may take place at a significant rate. In a rigorous model, it is impossible to separate the problems of chirality from energetic considerations and from explicitly taking into account the deformability of molecules. This underlines the importance of the global chirality properties of a whole range of formal nuclear arrangements. In a global approach to the problems of molecular chirality, it appears worthwhile to consider the nuclear configuration space approach where all possible arrangements of a given stoichiometric family of nuclei are considered. Such a stoichiometric family includes all isomers, intermediates and decomposition products of all molecules and their transition structures with a given atomic composition, as well as all distorted conformations of the above. The global approach leads to the recognition of several rules on the presence of stable chiral nuclear configurations within families of nuclear arrangements, on the facility of configuration inversion and racemization processes, and on chirality changes due to electronic excitation.
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Mezey, P.G. (1991). A global approach to molecular chirality. In: Mezey, P.G. (eds) New Developments in Molecular Chirality. Understanding Chemical Reactivity, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3698-3_9
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DOI: https://doi.org/10.1007/978-94-011-3698-3_9
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