Summary
This paper reviews the process of ultrafiltration through the walls of capillary blood vessels. Capillaries are 5µm to 20µm in diameter and their walls are made of a single layer of flattened endothelial cells which act as a barrier to plasma proteins but allow water and low molecular weight hydrophil ic solutes to exchange between the capillary blood and the surrounding tissues. Net fluid movements are driven by differences in hydrostatic pressure and by differences in osmotic pressure which arise from differences in concentration of the plasma proteins. The interaction between the surface coat of the endothelial cells and plasma proteins is important for the maintenance of normal hydraulic permeability and molecular selectivity of the capillary ultrafilter. Capillaries of the glomeruli of the kidney are specialised for ultrafiltration. They have high hydraulic permeabilities but the driving force for ultrafiltration is relatively low allowing filtration equilibrium to be approached or even achieved during a single transit. The relatively low pressures may contribute to the long term efficiency of the glomerular capillaries as ultrafilters and the part played by ultrafiltration in overall functioning of the kidneys.
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References
Adamson, R.H. (1990) ‘Permeability of frog mesenteric capillaries after partial pronase digestion of the endothelial glycocalyx’, J.Physiol. 428, 1–13.
Brenner, B.M., Deen, W.M. and Robertson, C.R. (1976) ‘Determinants of glomerular filtration rate’, Annual Review of Physiology, 38, 9–19.
Fried, T.A., McCoy, R.N., Osgood, R.W. and Stein, J.H. (1986) ‘Effect of albumin on glomerular ultrafiltration coefficient in isolated perfused dog glomerulus’, Am.J.Physiol., 250, F901–F906.
Kanwar, Y.S. and Farquhar, M. (1979) ‘Presence of heparin sulphate in the glomerular basement membrane’, Proceedings of the National Academy of Sciences Washington, 76, 1301–1307.
Lassen, N.A. (1970) ‘Contribution to discussion’, In Crone. C. and Lassen, N.A., eds. Capillary Permeability, p549, Munksgaard, Copenhagen.
Michel, C.C. (1981) ‘The flow of water through the capillary wall’. In: Water Transport Across Epithelia. Edited by H.H. Ussing, N.Bindster, N.A.Lassen and O.Sten-Knudsen. Copenhagen, Munksgaard, p268–279.
Michel, C.C. (1984) ‘Fluid movements through capillary walls’. In: Renkin, E.M. and Michel, C.C. eds. American Handbook of Physiology, Section 2 Vol IV Microcirculation. American Physiological Society Washington DC pp 375–409.
Michel, C.C. (1988) ‘Capillary permeability and how it may change’. J.Phvsiol. 404, 1–29.
Michel, C.C. and Phillips, M.E. (1985) ‘The effects of bovine serum albumin and a form of cationised ferritin upon the molecular selectivity of the walls of single frog capillaries’, Microvascular Research, 29, 190–203.
Michel, C.C. and Phillips, M.E. (1987) ‘Steady state fluid filtration at different capillary pressures in perfused frog mesenteric capillaries’, J.Phvsiol, 388, 421–435.
Michel, C.C., Phillips, M.E. and Turner, M.R. (1985) ‘The effects of native and modified bovine serum albumin on the permeability of frog mesenteric capillaries’, J.Phvsiol, 360, 333–346.
Renkin, E.M. and Gilmore, J.D. (1973) ‘Glomerular filtration’. In Handbook of Physiology, Renal Physiology, eds: Orloff, J. & Berliner, R.W.) pp 185–248, American Physiological Society, Washington DC.
Robinson, J.R. (1988) ‘Reflections on renal function (2nd edition)’ Blackwells Scientific Publications, Oxford.
Schneeberger, E.E. and Hamelin, M. (1984) ‘Interaction of circulating proteins with pulmonary endothelial glycocalyx and its effect on endothelial permeability’, American Journal of Physiology, 247, H206–H217.
Starling, E.H. (1896) ‘On the absorption of fluids from connective tissue spaces’, J.Physiol., 19, 312–326.
Turner, M.R., Clough, G. and Michel, C.C. (1983) ‘The effects of cationised ferritin and native ferritin upon the filtration coefficient of single frog capillaries. Evidence that proteins in the endothelial cell coat influence permeability’, Microvasc.Res., 25, 205–222.
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© 1991 Elsevier Science Publishers Ltd
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Michel, C.C. (1991). Ultrafiltration in Living Capillaries. In: Turner, M.K. (eds) Effective Industrial Membrane Processes: Benefits and Opportunities. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3682-2_17
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DOI: https://doi.org/10.1007/978-94-011-3682-2_17
Publisher Name: Springer, Dordrecht
Print ISBN: 978-1-85166-723-9
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