Summary
For the use in medicine we are interested in ligands that form kinetically stable complexes with radioactive alkali cations. The spherands form very stable complexes with Li+ and Na+, but reject the larger alkali cations like K+ and Rb+. Our objective was to synthesize macrocyclic hosts based on a m-teranisyl unit and a calix[4]arene moiety that form kinetically stable complexes not only with Na+ and K+ but also with Rb+.
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References
Radiopharmaceuticals II, Society Nuclear Medicine, New York, 1979.
a)G. van Herk, PhD Thesis, Groningen, 1976
b)D. de Zeeuw, PhD Thesis, Groningen, 1980.
a)R.M. Izatt, J.S. Bradshaw, S.A. Nielsen, J.D. Lamb and J.J. Christensen, Chem. Rev. 85, 271(1985)
b)B.G. Cox, J. Garcia-Rosas and H. Schneider, J.Am.Chem.Soc. 103, 1054 and 1384(1981).
D. J. Cram, T. Kaneda, R.C. Helgeson and G.M. Lein, J.Am.Chem.Soc. 101, 6752(1979).
K. E. Koenig, G.M. Lein, P. Stuckler, T. Kaneda and D.J. Cram, J.Am.Chem.Soc. 101, 3553(1979).
a)P.J. Dijkstra, B.J. van Steen and D.N. Reinhoudt, J.Org.Chem. 51, 5127(1986)
b)P.J. Dijkstra, H.J. den Hertog Jr., B.J. van Steen, S. Zijlstra, M. Skowronska-Ptasinska, D.N. Reinhoudt, J. van Eerden and S. Harkema, J.Org.Chem. 52, 2433(1987)
c)P.J. Dijkstra, M. Skowronska-Ptasinska, D.N. Reinhoudt, H.J. den Hertog Jr., J. van Eerden, S. Harkema and D. de Zeeuw, J.Org.Chem. 52, 4913(1987)
d)P.J. Dijkstra, H.J. den Hertog Jr., J. van Eerden, S. Harkema and D.N. Reinhoudt, J.Org.Chem. 53, 374(1988)
e)P.J. Dijkstra, B.J. van Steen, B.H.M. Hams, H.J. den Hertog Jr. and D.N. Reinhoudt, Tetrahedron Lett. 27, 3183(1986).
a)D.J. Cram, S.P. Ho, C.B. Knobler, E. Maverick and K.N. Trueblood, J.Am.Chem.Soc. 108, 2989(1986)
b)D.J. Cram and S.P. Ho, J.Am.Chem.Soc. 108, 2998(1986).
P.J. Dijkstra, J.A.J. Brunink, K.-E. Bugge, D.N. Reinhoudt, S. Harkema, R. Ungaro, F. Ugozzoli and E. Ghidini, J.Am.Chem.Soc. 111, 7567(1989).
C.D. Gutsche, Calixarenes, Royal Society of chemistry, Cambridge, 1989.
C.D. Gutsche, M. Iqbal and D. Stewart, J.Org.Chem. 51, 742(1986).
a) G. Alfieri, E. Dradi, A. Pochini, R. Ungaro and G.D. Andreetti, J.Chem.Soc.Chem.Commun. 1075(1983)
b) R. Ungaro, A. Pochini and G.D. Andreetti, J.Inclusion Phenom 2, 199(1984)
c) E. Ghidini, F. Ugozzoli, R. Ungaro, S. Harkema, A.A. El-Fadl and D.N. Reinhoudt, J.Am.Chem.Soc. accepted for publication.
a)D.J. Cram, T. Kaneda, R.C. Helgeson, S.B. Brown, C.B. Knobler, E. Maverick and K.N. Trueblood, J.Am.Chem.Soc. 107, 3645(1985)
b)D.J. Cram and G.M. Lern, J.Am.Chem.Soc. 107, 3657(1985).
a)F. de Jong, D.N. Reinhoudt, C.J. Smit and R. Huis, Tetrahedron Lett. 4783(1976)
b)F. de Jong, D.N. Reinhoudt and R. Huis, Tetrahedron Lett. 3985(1977).
G. M. Lein and D.J. Cram, J.Am.Chem.Soc. 107, 448(1985).
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Bakker, W.I.I., Reinhoudt, D.N. (1991). Calixspherands as Ligands for the Complexation of Radioactive Rubidium—81. In: Cecille, M.L., Casarci, M., Pietrelli, L. (eds) New Separation Chemistry Techniques for Radioactive Waste and Other Specific Applications. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3654-9_20
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DOI: https://doi.org/10.1007/978-94-011-3654-9_20
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