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Antithrombotics pp 27–48Cite as

Role of Nitric Oxide in Endothelial Cell - Platelet Interactions

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 126))

Abstract

Nitric oxide (NO) is synthesized by constitutive and inducible NO synthases. The formation of NO by the constitutive enzyme and subsequent stimulation of the soluble guanylate cyclase in the vascular system is part of the control mechanisms which regulate haemostasis and counteract thrombosis. An impaired production of NO may result in platelet activation and thrombosis. In contrast, a prolonged activation of constitutive and/or the expression of inducible NO synthases may provide amounts of NO capable of inhibiting platelet function and inducing bleeding diathesis. Finally, the pharmacological administration of drugs which generate NO or compounds which modulate the activity of NO synthases may prove to be of therapeutic value for restoration of the haemostatic balance.

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Authors
  1. M. W. Radomski
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  2. S. Moncada
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  1. University of Antwerp (UIA)., Antwerp, Belgium

    Arnold G. Herman (Professor of Pharmacology) (Professor of Pharmacology)

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Radomski, M.W., Moncada, S. (1991). Role of Nitric Oxide in Endothelial Cell - Platelet Interactions. In: Herman, A.G. (eds) Antithrombotics. Developments in Cardiovascular Medicine, vol 126. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3484-2_2

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