Abstract
Peptic ulcers are very common and are usually diagnosed by radiography or endoscopy. Sucralfate is an effective medication for the treatment of gastroduodenal ulcers, and Technetium 99m (99mTc) labeled sucralfate has been found to adhere to ulcers.
We examined the reliability of confirming the diagnosis of gastroduodenal ulcers, previously detected by endoscopy and histology, by means of sucralfate labeled with 99mTc, imaging one and two hours after oral administration. Fifty-four out of 64 patients were positive by scintigraphy with our method (sensitivity: 84.3%). Scintigraphy was positive in all the patients who hemorrhaged during the procedure. Our method was specific in 75% for the detection of peptic ulcers, and there were no false positive results.
The procedure was well tolerated and non-invasive. It was performed at the bedside in critically ill patients and in follow-up for fragile patients. The results obtained in these patients were extremely encouraging.
The advantages and inconveniences of gastric endoscopy, radiography, and scintigraphy are discussed and compared.
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Puttemans, N.A.M., Andre, P.P., Jamsin, S.A.M.J., Balikdjian, D.P.H., Lustman, F. (1991). Detection of gastroduodenal ulcers using Technetium-99m-labeled sucralfate. In: Biersack, J., Cox, H. (eds) Nuclear Medicine in Gastroenterology. Developments in Nuclear Medicine, vol 18. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3316-6_9
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DOI: https://doi.org/10.1007/978-94-011-3316-6_9
Publisher Name: Springer, Dordrecht
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