Abstract
While the incidence of gastric cancer (GC) has been decreasing world wide for over 30 years and has lost its number one world cancer position last year to lung cancer it is still the commonest cancer in the developing countries and because of its poor prognosis has the highest mortality. It is very common in Eastern Asia, Latin America, Eastern Europe and in Europe there is a North-South and East-West gradient (1). In the UK there is also a marked social class gradient in the disease. Furthermore, migrants from high risk areas, such as Japan, moving to low-risk areas (eg Hawaii & California) will retain the high risk for the disease unless they migrated in childhood or early adult life (2). This would suggest an environmental cause for GC with such factors having their effect early in life.
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Reed, P.I. (1991). Diet and Precancerous Lesions of the Stomach. In: Hill, M.J., Giacosa, A. (eds) Causation and Prevention of Human Cancer. Developments in Oncology, vol 63. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3308-1_6
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DOI: https://doi.org/10.1007/978-94-011-3308-1_6
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