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Human Cancer in Primary Culture, A Handbook pp 253–260Cite as

Ovarian Tumours

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Part of the book series: Developments in Oncology ((DION,volume 64))

Abstract

The growth of ovarian cancer under experimental laboratory conditions provides one of the main success stories in human tumour propagation, with numerous reports detailing investigations using biopsy material directly:

  1. (i)

    to clone tumour cells in semi-solid media;

  2. (ii)

    to originate primary monolayer cultures, leading to the establishment of continuous cell lines in vitro; and/or

  3. (iii)

    to establish xenografted tumours in nude mice.

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References

  • Aapro, M.S., Charrin, C., Krauer, F. and Delaloye, J.F. (1989). MG-CSF interferes with hydrocortisone in a clonogenic assay of ovarian cancer cells. In: C.H. Dittrich and M.S. Aapro (eds.) E.O.R.T.C. Clonogenic Assay Screening Group Report. Drugs, Cells and Cancer. (p. 4).

    Google Scholar 

  • Alberts, D.S., Chen, H.S.G., Salmon, S.E., Surwitt, E.A., Young, L. and Moon, T.E. (1981). Chemotherapy of ovarian cancer directed by the human tumour stem cell assay. Cancer Chemother. Pharmacol. 6: 279–285.

    PubMed  CAS  Google Scholar 

  • Balconi, G., Broggini, M., Erba, E., D’Incalci, M., Colombo, N., Mangioni, C. and Bertolero, F. (1988). Human ovarian tumours in primary culture, growth, characterization and initial evaluation of the response to cis-platinum treatment in vitro. Int. J. Cancer 41: 809–818.

    Article  PubMed  CAS  Google Scholar 

  • Benard, J., Da Silva, J. and Riou, G. (1983). Culture of clonogenic cells from various human tumours: Drug sensitivity assay. Eur. J. Cancer Clin. Oncol. 19: 65–72.

    Article  PubMed  CAS  Google Scholar 

  • Benard, J., Da Silva, J., De Blois, M.C., Boyer, P., Duvillard, P., Chiric, E., and Riou, G. (1985). Characterization of a human ovarian adenocarcinoma line, IGROVI, in tissue culture and in nude mice. Cancer Res. 45: 4970–4979.

    PubMed  CAS  Google Scholar 

  • Bertelsen, C.A., Sondak, V.K., Mann, B.D., Kovn, E.L. and Kern, D.H. (1984). Chemosensitivity testing of human solid tumours: A review of 1582 assays with 258 clinical correlations. Cancer 53: 1240–1245.

    Article  PubMed  CAS  Google Scholar 

  • Bertoncello, I., Bradley, T.R., Campbell, J.J., Day, A.J., McDonald, LA. and McLeish, G.R. (1982). Limitations of the clonal agar assay for the assessment of primary human ovarian tumour biopsies. Br. J. Cancer 45: 803–811.

    Article  PubMed  CAS  Google Scholar 

  • Briers, T.W., Stroobants, P., Vandeputte, T.M., Nouwen, E.J., Conraads, M.V., Eestermans, G., Van Buckstaele, D., and De Broe, M.E. (1989). Establishment and characterization of a human ovarian neoplastic cell line, DO-s. Cancer Res. 49: 5153–5161.

    PubMed  CAS  Google Scholar 

  • Buick, R.N., Pullano, R. and Trent, J.M. (1985). Comparative properties of five human ovarian adenocarcinoma cell lines. Cancer Res. 45: 3668–3676.

    PubMed  CAS  Google Scholar 

  • Courtenay, D. (1983). The Courtenay clonogenic assay. In: P.P. Dendy and B.T. Hill (eds.). Human Tumour Drug Sensitivity Testing In Vitro, Academic Press, London. pp. 103–111.

    Google Scholar 

  • Erba, E., Vaghi, M., Pepe, S., Amato, G., Bistolfi, M., Ubezio, P., Mangioni, C., Landoni, F. and Morasca, L. (1985). DNA index of ovarian carcinomas from 56 patients: In vivo in vitro studies. Br. J. Cancer 52: 565–573.

    Article  PubMed  CAS  Google Scholar 

  • Freedman, R.S., Pihl, E., Kusyk, C., Gallager, H.S. and Rutledge, F. (1978). Characterization of an ovarian carcinoma cell line. Cancer 42: 2352–2359.

    Article  PubMed  CAS  Google Scholar 

  • Hamburger, A.W. and Salmon, S.E. (1977). Primary bioassay of human tumor stem cells. Science 197: 461–463.

    Article  PubMed  CAS  Google Scholar 

  • Hamburger, A.W., Salmon, S.E., Kim, M.B., Trent, J.M., Soehnlen, B.J. and Alberts, D.S. (1978). Direct cloning of human ovarian carcinoma cells in agar. Cancer Res. 38: 3438–3444.

    PubMed  CAS  Google Scholar 

  • Hamburger, A.W. (1983). The Salmon-Hamburger’ stem’ cell assays. In: P.P. Dendy and B.T. Hill (eds.) Human Tumour Drug Sensitivity Testing In Vitro. Academic Press, London. pp. 113–119.

    Google Scholar 

  • Hamilton, T.C., Young, R.C., McKoy, W.M., Grotzinger, K.R., Green, J.A., Chu, E.W., Whang-Peng, J., Rogan, A.M., Green, W.R. and Ozols, R.F. (1983). Characterization of a human ovarian carcinoma cell line (NIH: OVCAR-3) with androgen and estrogen receptors. Cancer Res. 43: 5389–5397.

    Google Scholar 

  • Hamilton, T.C., Young, R.C., Ozols, R.F. (1984). Experimental model systems of ovarian cancer applications to the design and evaluation of new treatment approaches. Semin. Oncol. 11: 285–298.

    PubMed  CAS  Google Scholar 

  • Hanauske, A.R. and Von Hoff, D.D. (1986). The value of the human tumour cloning assay in ovarian cancer. Clin. Obstet. Gynecol. 29: 638–645.

    Article  PubMed  CAS  Google Scholar 

  • Hanson, J., Coombs, A. and Moore, J.L. (1984). Drug testing using a soft agar stem cell assay on patient and xenograft tumour material. Int. J. Radiat. Oncol. Biol. Phys. 10: 1697–1700.

    Article  PubMed  CAS  Google Scholar 

  • Hill, B.T. (1983). Overview of clonogenic assays In: P.P. Dendy and B.T. Hill (eds.) Human Tumour Drug Sensitivity Testing In Vitro. Academic Press, London. pp. 103–111.

    Google Scholar 

  • Hill, B.T., Whelan, R.D.H., Gibby, E.M., Sheer, D., Hosking, L.K., Shellard, S.A. and Rupniak, H.T. (1987). Establishment and characterization of three new human ovarian carcinoma cell lines and initial evaluation of their potential in experimental chemotherapy studies. Int. J. Cancer 39: 219–225.

    Article  PubMed  CAS  Google Scholar 

  • Hosking, L.K. and Hill, B.T. (1989). Differential influence of recombinant granulocytic macrophage (GM) colony-stimulating factor (CSF) on the colony forming abilities of certain human tumour cell lines in vitro. In: C.H. Dittrich and M.S. Aapro (eds.) E.O.R.T.C. Clonogenic Assay Screening Group Report. Drugs, Cells and Cancer. pp. 2–3.

    Google Scholar 

  • Horowitz, A.T., Treves, A.J., Voss, R., Okon, E., Fuks, Z., Davidson, L. and Biran, S. (1985). A new human ovarian carcinoma cell line: Establishment and analysis of tumour associated markers. Oncology 42: 332–337.

    Article  PubMed  CAS  Google Scholar 

  • Ishiwata, I., Ishiwata, C., Soma, M. and Ishikawa, H. (1987). Establishment of HUOCA-11, a human ovarian clear cell adenocarcinoma cell line, and its angiogenic activity. J. Natl. Cancer Inst. 78: 667–671.

    PubMed  CAS  Google Scholar 

  • Kern, D.H., Campbell, M.A., Cochran, A.J., Burk, M.W. and Morton, D.L. (1982). Cloning of human solid tumours in soft agar. Int. J. Cancer. 30: 725–729.

    Article  PubMed  CAS  Google Scholar 

  • Langdon, S.P., Lawrie, S.S., Hay, F.G., Hawkes, M.M., McDonald, A., Hayward, I.P., Schol, D.J., Hilgers, J., Leonard, R.C.F. and Smyth, J.F. (1988). Characterization and properties of nine human ovarian adenocarcinoma cell lines. Cancer Res. 48: 6166–6172.

    PubMed  CAS  Google Scholar 

  • Ozols, R.F., Hogan, W.M. and Young, R.C. (1984). Direct cloning of human ovarian cancer in soft agar: Clinical limitations and pharmacologic applications. Recent Results in Cancer Res. 94: 41–50.

    Article  CAS  Google Scholar 

  • Page, R.H., Tilchen, E.J. and Davis, H.L. (1988). Effects of tumour cell viability and inoculum density on growth parameters in the human tumour, soft-agar clonogenic assay. Cancer Res. 48: 3944–3948.

    PubMed  CAS  Google Scholar 

  • Peri, G., Zanaboni, F., Rossini, S., Mangioni, C., Landoni, F., Epis, A. and Mantovani, A. (1986). Evaluation of the interaction of mononuclear phagocytes with ovarian carcinoma cells in a colony assay. Br. J. Cancer 53: 47–52.

    Article  PubMed  CAS  Google Scholar 

  • Rey, A.A., Cupissol, D., Ursule, E. and Serrou, B. (1983). Prognostic value of the human tumour clonogenic assay (HTCA) in patients with ovarian carcinomas. Int. J. Cell Cloning 1:289–294.

    Google Scholar 

  • Runge, H.M., Teufel, G., Neulen, J., Geyer, H. and Pfleiderer, A. (1986). In vitro responsiveness of ovarian epithelial carcinomas to endocrine therapy. Cancer Chemother. Pharm. 16: 58–63.

    Article  CAS  Google Scholar 

  • Rupniak, H.T., Marks, P., Watkins, S., Bourne, G., Slevin, M., Bancroft-Livingston, G.H., Simmons, C.A., and Hill, B.T. (1982). Drug sensitivities of human tumour cells obtained directly from biopsy material. Current Chemotherapy and Immunotherapy, Proc. 12th International Congress of Chemotherapy, 1981. pp. 1274–1276.

    Google Scholar 

  • Sikic, B.I., Evans, T.L., Mackintosh, F.R. and Smith, H.S. (1982). Human tumour clonogenic assays — studies of growth and drug sensitivity. Proc. Am. Assoc. Cancer Res. 23: 186.

    Google Scholar 

  • Simon, W.E., Albrecht, M., Hansel, M., Dietel, M. and Holzel, F. (1983). Cell lines derived from human ovarian carcinomas: Growth stimulation by gonadotrophin and steroid hormones. J. Natl. Cancer Inst. 70: 839–845.

    PubMed  CAS  Google Scholar 

  • Spitzer. G., Singletary, E., Tomasonvic, B., Umback, G., Hu, Y. and Merchant, N. (1984). Human tumour cloning culture supplements. In: S.E. Salmon and J.M. Trent (ed.) Human Tumour Cloning, Grune and Stratton Inc., Orlando. pp. 215–288.

    Google Scholar 

  • Trent, J.M. (1980). Cytogenetic analysis of human tumour cells cloned in agar — In: S.E. Salmon (ed.) Cloning of human tumour stem cells. Alan R. Liss, New York. pp. 165–167.

    Google Scholar 

  • Uehara, S., Abe, H., Hoshiai, H., Yajima, A., and Suzuki, M. (1984). Establishment and characterization of an ovarian endometrioid carcinoma cell line. Gynecol. Oncol. 17: 314–325.

    Article  PubMed  CAS  Google Scholar 

  • Van Haaften-Day, C., Russel, P., Carr, S., and Wright, L. (1988). Development and characterization of a human cell line from an ovarian mixed mullerian tumour (carcinosarcoma). In Vitro 24: 965–971.

    Google Scholar 

  • Van Haaften-Day, C., Russel, P., Rugg, C., Willis, E.J. and Tattersall, M.H.N. (1983). Flow cytometric and morphological studies of ovarian carcinoma cell lines and xenografts. Cancer Res. 43: 3725–3731.

    PubMed  Google Scholar 

  • Van Halze, G.A., Leiber, M.W., Fleming, T.R. and Kovach, J.S. (1982). Studies of the human tumour stem cell assay of ovarian carcinomas. Stem Cells 1: 294–298.

    Google Scholar 

  • Van Niekerk, C.C., Poels, L.G., Jap, P.H.K., Smeets, D.F.C.M., Thomas, C.M.G., Ramaekers, F.C.S. and Vooijs, G.P. (1988). Characterization of a human ovarian carcinoma cell line, OTN 14, derived from a mucinous cystadenocarcinoma. Int. J. Cancer 42: 104–111.

    Article  PubMed  Google Scholar 

  • Von Hoff, D.D., Clark, G.M., Stogdill, B.J., Sarosdy, M.F., O’Brien, M.T. and Casper, J.T. (1983). Prospective clinical trial of a human tumour cloning system. Cancer Res. 43: 1926–1931.

    Google Scholar 

  • Von Hoff, D.D., Cowan, J., Harris, G. and Reisdorf, G. (1981). Human tumour cloning: Feasibility and clinical correlations. Cancer Chemother Pharmacol. 6: 265–271.

    Google Scholar 

  • Welander, C.E. (1983). In vitro testing of ovarian carcinomas: basis for planning therapy. In: E Grundmann (ed.) Cancer Campaign Gustav Fischer Verlag, Stuttgart. pp. 51–58.

    Google Scholar 

  • Xu, M.J., Alberts, D.S., Lui, R., Leibovitz, A. and Liu, Y. (1989). In vitro evaluation of cisplatin interaction with doxorubicin or 4-hydroperoxycyclophosphamide against human gynecologic cancer lines. Cancer Chemother. Pharm. 25: 89–94.

    Article  CAS  Google Scholar 

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Authors
  1. Richard D. H. Whelan
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  2. Louise K. Hosking
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  3. Sharon A. Shellard
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  4. Bridget T. Hill
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Editor information

Editors and Affiliations

  1. Institute of Urology, University College, London, UK

    J. R. W. Masters

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© 1991 Springer Science+Business Media Dordrecht

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Whelan, R.D.H., Hosking, L.K., Shellard, S.A., Hill, B.T. (1991). Ovarian Tumours. In: Masters, J.R.W. (eds) Human Cancer in Primary Culture, A Handbook. Developments in Oncology, vol 64. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3304-3_11

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  • DOI: https://doi.org/10.1007/978-94-011-3304-3_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5459-1

  • Online ISBN: 978-94-011-3304-3

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