Abstract
A candidate for the human SAA3 gene has been cloned and characterized. The sequence derived from this clone (HDgl-1) for amino acids 1–12 most closely resembles that of rabbit SAA3 with which it has 75% identity, compared to 25% identity with the corresponding sequences in human SAAl and SAA2. In the region spanning exon 3—exon 4, however, HDgl-1 and the human SAAl and SAA2 genes are 87% homologous. The exon 3 sequence of HDg1-1, as well as the exon 3 sequence of this gene in four unrelated individuals, was found to have an “extra” base which would distrupt the appropriate reading frame for SAA and generate a premature stop codon. In addition, no mRNA corresponding to the HDgl-1 sequence has been detected. These data point to the possibility that the SAA3 gene may not be expressed in humans.
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© 1991 Springer Science+Business Media Dordrecht
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Kluve-Beckerman, B., Brinckerhoff, C., Benson, M.D. (1991). Sequence Analysis of a Third Human SAA Gene. In: Natvig, J.B., et al. Amyloid and Amyloidosis 1990. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3284-8_6
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DOI: https://doi.org/10.1007/978-94-011-3284-8_6
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