Abstract
Investigation of liver, urine, and serum of amyloidosis patient MAL established the presence of two idiotypically different kappa L-chains. The liver kappa-chain was isolated as an intact fibril precursor from the sodium chloride extracts of the liver and as a kappa L-chain fragment (pos.1-113) from the water extracts representing the fibril. The missing C-part was found in the urine. Kappa L-chain fragments were isolated from the urine consisting of V- and glycosylated J-C fragments reported in the previous paper. Inspite of 20 amino acid substitutions no V-region sequences characteristic of the liver fragment could be detected in the urine and vice versa. The MAL serum contained an intact monoclonal IgG1 (kappa) protein whose L-chain was structurally identical to the urinary L-chain fragments.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Kratzin, H. D., Pick, A. I., and Hilschmann, N. (1990) ‘Complete amino-acid sequence of a kappa light chain fragment isolated from the urine of amyloidosis patient MAL’, in Amyloidosis, Natvig, J. B., Oystein, O., Husby, G., Husebekk, A., Skogen, B., Sletten, K., Westermark, P., (eds), Kluwer academic publishers, Dordrecht, Netherlands, in press.
Pras, M., Schubert, M., Zucker-Franklin, D., Rimon, A., and Franklin, E. C. (1968) ‘The characterization of soluble amyloid prepared in water’, J. Clin. Invest. 47, 924–933.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Rodilla Sala, E., Kratzin, H.D., Pick, A.I., Hilschmann, N. (1991). Biclonality in Amyloidosis Patient MAL: One Clone Produncing an Amyloidogenic, the Other a Non-Amyloidogenic Kappa L-Chain — AL Amyloidosis. In: Natvig, J.B., et al. Amyloid and Amyloidosis 1990. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3284-8_40
Download citation
DOI: https://doi.org/10.1007/978-94-011-3284-8_40
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5450-8
Online ISBN: 978-94-011-3284-8
eBook Packages: Springer Book Archive