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SAA Isotypes in Patients with Secondary Amyloidosis

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Amyloid and Amyloidosis 1990

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Abstract

SAA isotypes were examined in a group of patients from Papua New Guinea where there is a very high incidence of amyloidosis. The expression of SAA2ß was more common than observed in patients from Europe/USA but similar to that observed in a group of patients from Malawi with malaria. After examination of matched pairs of patients with and without amyloidosis we could find no evidence for qualitative differences in isotypes present in patients with or without amyloidosis. We have also looked at the isotypes in a group of patients from Lund with rheumatoid disease, with or without amyloidosis, matched for age, sex and duration of disease. There was no qualitative difference in SAA isotype expression in individuals who develop amyloidosis and those who do not. There was no evidence for quantitative differences in SAA1 and SAA2α in patients who had amyloidosis and those who did not. Further studies are in progress on the quantitation of isotypes with arginine at the N-terminal.

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Author information

Authors and Affiliations

  1. Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, Keppel St., London, WCIE 7HT, UK

    J. G. Raynes & K. P. W. J. McAdam

  2. Department of Rheumatology, University Hospital of Lund, S-221 85, Lund, Sweden

    R. Hultquist

  3. Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK

    M. Molyneux

  4. Department of Communicable Diseases St George’s, Hospital Medical School, Tooting, London, SW17 ORE, UK

    G. Griffin

Authors
  1. J. G. Raynes
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  2. R. Hultquist
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  3. M. Molyneux
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  4. G. Griffin
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  5. K. P. W. J. McAdam
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Editor information

Editors and Affiliations

  1. Institute of Immunology and Rheumatology, University of Oslo, Oslo, Norway

    Jacob B. Natvig

  2. Oslo Sanitetsforenings, Rheumatism Hospital, University of Oslo, Oslo, Norway

    Øystein Førre

  3. Department of Rheumatology, University of Tromsø, Tromsø, Norway

    Gunnar Husby

  4. Department of Immunology and Bloodbank, University of Tromsø, Tromsø, Norway

    Anne Husebekk  & Bjørn Skogen  & 

  5. Department of Biochemistry, University of Oslo, Oslo, Norway

    Knut Sletten

  6. Department of Pathology, University of Linköping, Linköping, Sweden

    Per Westermark

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© 1991 Springer Science+Business Media Dordrecht

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Raynes, J.G., Hultquist, R., Molyneux, M., Griffin, G., McAdam, K.P.W.J. (1991). SAA Isotypes in Patients with Secondary Amyloidosis. In: Natvig, J.B., et al. Amyloid and Amyloidosis 1990. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3284-8_30

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  • DOI: https://doi.org/10.1007/978-94-011-3284-8_30

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5450-8

  • Online ISBN: 978-94-011-3284-8

  • eBook Packages: Springer Book Archive

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