Abstract
A monoclonal antibody(aSP01) and a polyclonal antibody was raised against a synthetic peptide corresponding to residues(N:1-10, SP01) of the beta-protein. Using the aSP01 and sandwitch ELISA technique immunoreactivities in sera were determined for four groups, three affected(Alzheimer’s disease, senile dementia of Alzheimer’s type(AD/ SDAT), multi-infarct dementia(MID), dementia of not otherwise satisfied (NOS)), and a non-affected group. Whereas a high value in the cross-reactivity was observed on AD(35.11±7.91), relatively low values were obtained for the latter groups(MID; 16.76±2.58, N0S;13.28±2.20, non-demented; 14.41 ±.1. 94) • No difference in the mean value of the CRM was shown between male and female groups(male;16.04±3.51, female; 14.99±2.47). Practically no correration was observed between the age and CRM of the two affected groups(AD;r=-0.0585, MID;r=0.0353)and non-affected group(r=0.2758).
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© 1991 Springer Science+Business Media Dordrecht
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Shinoda, T., Kametani, Y., Miyanaga, K., Iinuma, K. (1991). Screening with Monoclonal Anti Beta-Protein Antibody for Immuno-Reactivity in the Sera of Patients with Alzheimer’s Disease. In: Natvig, J.B., et al. Amyloid and Amyloidosis 1990. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3284-8_222
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DOI: https://doi.org/10.1007/978-94-011-3284-8_222
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