Skip to main content
SpringerLink
Log in

Biosynthesis and Processing of SAA by Mouse L-Cells Transfected with the Human SAAg9 Gene

  • Chapter
Amyloid and Amyloidosis 1990

  • 22 Accesses

Abstract

Pulse-chase studies of SAA biosynthesis and processing in mouse L-cells transfected with the SAAg9 gene have shown that, over a 2h time period, intracellular SAA does not show amino-terminal trimming. Extracellular SAA, although principally composed of the pI=8.0 isoform, shows limited conversion from the pI=8.0 to pl=7.4 isoform over a 2h period.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Strachan A.F., de Beer, F.C., van der Westhuyzen D.R. and Coetzee G.A. (1988) “Identification of three isoform patterns of human serum amyloid A protein”, Biochem. J. 250, 203–207.

    PubMed  CAS  Google Scholar 

  • Strachan A.F., Brandt W.F., Woo P., van der Westhuyzen D.R., Coetzee G.A. and de Beer M.C. et al (1989) “Human serum amyloid A protein: the assignment of the six major isoforms to three published gene sequences and evidence for two genetic loci.” J. Biol. Chem. 264, 18368–18373.

    PubMed  CAS  Google Scholar 

  • Woo P., Sipe J., Dinarello C.A. and Colten H.R. (1987) “Structure of a human serum amyloid A gene and modulation of its expression in transfected L-cells”, J. Biol. Chem. 262, 15790–15795.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. U.C.T./M.R.C. Unit for the Cell Biology of Atherosclerosis, University of Cape Town, Observatory, 7925, South africa

    I. P. Fraser, D. R. Van Der Westhuyzen & G. A. Coetzee

  2. Department of Rheumatology, University of Kentucky Medical Center, South africa

    F. C. De Beer & A. F. Strachan

  3. Department of Internal Medicine, University of Stellenbosch Medical School, P.O. Box 63, Tygerberg, 7505, South Africa

    E. G. Shephard

Authors
  1. I. P. Fraser
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. R. Van Der Westhuyzen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. A. Coetzee
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. C. De Beer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. G. Shephard
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. F. Strachan
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Immunology and Rheumatology, University of Oslo, Oslo, Norway

    Jacob B. Natvig

  2. Oslo Sanitetsforenings, Rheumatism Hospital, University of Oslo, Oslo, Norway

    Øystein Førre

  3. Department of Rheumatology, University of Tromsø, Tromsø, Norway

    Gunnar Husby

  4. Department of Immunology and Bloodbank, University of Tromsø, Tromsø, Norway

    Anne Husebekk  & Bjørn Skogen  & 

  5. Department of Biochemistry, University of Oslo, Oslo, Norway

    Knut Sletten

  6. Department of Pathology, University of Linköping, Linköping, Sweden

    Per Westermark

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Fraser, I.P., Van Der Westhuyzen, D.R., Coetzee, G.A., De Beer, F.C., Shephard, E.G., Strachan, A.F. (1991). Biosynthesis and Processing of SAA by Mouse L-Cells Transfected with the Human SAAg9 Gene. In: Natvig, J.B., et al. Amyloid and Amyloidosis 1990. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3284-8_11

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-3284-8_11

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5450-8

  • Online ISBN: 978-94-011-3284-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation