Skip to main content

Microelectrodes in Biological Systems

  • Chapter

Part of the book series: NATO ASI Series ((NSSE,volume 197))

Abstract

The small size of microelectrodes enables their use as sensors in biological systems of easily oxidized chemical substances. Carbon-fiber electrodes implanted in the brain can be used to examine the dynamic concentration changes of the neurotransmitter dopamine. In thin slices of brain tissue, the electrodes can be used to simultaneously detect neurotransmitter secretion and oxygen use. At single cells secretion processes can be resolve in real time.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. R.N. Adams, Anal. Chem., 48, 1126A–1138A (1976).

    Article  CAS  Google Scholar 

  2. R. Kelly, R.M. Wightman, Anal. Chim. Acta, 187, 79–87 (1986).

    Article  CAS  Google Scholar 

  3. J.E. Baur, E.W. Kristensen, L.J. May, D.J. Wiedemann, R.M. Wightman, Anal. Chem., 60, 1268–1272 (1988).

    Article  CAS  Google Scholar 

  4. R.M. Wightman, L.J. May, A.C. Michael, Anal. Chem., 60, 769A–779A (1988).

    CAS  Google Scholar 

  5. C. Oh, T.W. Gardiner, G.V. Rebec, Brain Res., 480, 184–189 (1989).

    Article  CAS  Google Scholar 

  6. J.R. Cooper, F.E. Bloom, R.H. Roth, The Biochemical Basis of Neuropharmacology; Oxford University Press, Oxford, England, 1986.

    Google Scholar 

  7. R.M. Wightman, C. Amatore, R.C. Engstrom, P.D. Hale, E.W. Kristensen, W.G. Kuhr, L.J. May, Neuroscience, 25, 513–523 (1988).

    Article  CAS  Google Scholar 

  8. Voltammetry in the Neurosciences, J.B. Justice, Ed.; Humana Press, Clifton, NJ, 1987.

    Google Scholar 

  9. J.O. Schenk, E. Miller, M.E. Rice, R.N. Adams, Brain Res., 277, 1–8 (1983).

    Article  CAS  Google Scholar 

  10. F. Gonon, M. Buda, R. Cespuglio, M. Jouvet, J.F. Pujol. of Nature, 286, 902–904 (1980).

    Article  CAS  Google Scholar 

  11. G.A. Gerhardt, A.F. Oke, G. Nagy, B. Moghaddam, R.N. Adams, Brain Res., 290, 390–395 (1984).

    Article  CAS  Google Scholar 

  12. E.W. Kristensen, W.G. Kuhr, R.M. Wightman, Anal. Chem., 59, 1752–1757 (1987).

    Article  CAS  Google Scholar 

  13. W.H. Church, J.B. Justice, L.D. Byrd, Eur. J. Pharm., 357–348 (1987).

    Google Scholar 

  14. J.A. Near, J.C. Bigelow, R.M. Wightman, J. Pharmacol Exp. Ther., 245(3), 921–927 (1988).

    CAS  Google Scholar 

  15. W.G. Kuhr, A.G. Ewing, W.L. Caudill, R.M. Wightman, J. Neurochem., 43, 560–569 (1984).

    Article  CAS  Google Scholar 

  16. W.G. Kuhr, R.M. Wightman, G.V. Rebec, Brain Res., 418, 122–128 (1987).

    Article  CAS  Google Scholar 

  17. L.A. Powell, R.M. Wightman, J. Electroanal. Chem. Interfacial Electrochem., 117, 321–333 (1981).

    Article  CAS  Google Scholar 

  18. L.J. May, R.M. Wightman, Brain Res., 487, 311–320 (1989).

    Article  CAS  Google Scholar 

  19. L.J. May, R.M. Wightman, J. Neurochem., 53, 898–906 (1989).

    Article  CAS  Google Scholar 

  20. R.S. Kelly, R.M. Wightman, Brain Res., 423, 79–87 (1987).

    Article  CAS  Google Scholar 

  21. D. Lawson, L.D. Whitely, G.R. Martin, M.N. Szentirmay, J.I. Song, J. Electrochem. Soc., 135, 2247–2253 (1988).

    Article  CAS  Google Scholar 

  22. S.P. Wilson, O.H. Viveros, Exp. Cell Res., 133, 159–164 (1981).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Wightman, R.M., Kennedy, R.T., Wiedemann, D.J., Kawagoe, K.T., Zimmerman, J.B., Leszczyszyn, D.J. (1991). Microelectrodes in Biological Systems. In: Montenegro, M.I., Queirós, M.A., Daschbach, J.L. (eds) Microelectrodes: Theory and Applications. NATO ASI Series, vol 197. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3210-7_27

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-3210-7_27

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5416-4

  • Online ISBN: 978-94-011-3210-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics