Abstract
We evaluated the efficacy of methylprednisolone (MP) and dexamethasone (DM) in a randomized, prospective trial in 15 patients with primary and/or metastatic brain tumors. MP was given to 7 patients as an IV bolus of 1 gm, and tapered off in the following 7 days. DM was given to 8 patients at the daily dosage of 16 mgs for 7 days, and the day of surgery, and tapered off in the following 7 days. After 7 and 14 days, only the patients treated with MP showed a significant reduction in peritumoral brain edema volume measured by CT scan (P<0.01, P<0.0014, respectively). This study confirms the efficacy of MP in controlling peritumoral brain edema.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Black K.L., Hoff J.T., McGillicuddy J.E., Gebarski S.S. (1986) “Increased leukotriene C$ and vasogenic edema surrounding brain tumors in humans”, Ann. Neurol. 19, 592–595.
Blinderman E.E., Graf C.J., Fitzpatrick T. (1962) “Basic studies in cerebral edema: it’s control by corticosteoid (Solu-medrol)”, J. Neurosurg. 19, 319–324.
Cerutti P.A. (1985) “Prooxidant states and tumor promotion”, Science 227, 375–381.
Cooper C, Jones H.G., Weller R.O., Walker V. (1984) “Production of prostaglandins and thromboxane by isolated cells from intracranial tumors”, J. Neurol. Neurosurg. Psychiatry 47, 579–584.
Hatam A., Yu Z., Bergstrom M. Berggren B., Greitz T. (1982) “Effect of dexamethasone treatment on peritumoral brain edema: evaluation by computed tomography”, J. Comput. Assist. Tomogr. 6, 586–592.
Ikeda Y., Anderson J.H., Long D.M. (1989) “Oxygen free radicals in the genesis of traumatic and peritumoral brain edema”, Neurosurgery 24, 679–685.
Leiguarda R., Sierra J., Pardal C., Zambrano D. (1985) “Effects of large doses of methylprednisolone on supratentorial tumors”, Eur. Neurol. 24, 23–32.
Means E.D., Anderson D.K., Waters T.R. et alii (1981) “Effect of methylprednisolone in compression trauma to the feline spinal cord”, J. Neurosurg. 55, 200–208.
Miller J.D., Sakalas R., Ward J.D., Young H.F., Adams W.E., Vries J.K., Becker D.P. (1977) “Methylprednisolone treatment in patients with brain tumors”, Neurosurgery 1, 114–117.
Quindlen E.A., Bucher A.P. (1987) “Correlation of tumor plasminogen activator with peritumoral cerebral edema”, J. Neurosurg. 66, 729–733.
Senger D.R., Galli S.J., Dvorak A.M., Perruzzi C.A., Harvey V.S., Dvorak H.F. (1983) “Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid”, Science 219, 983–985.
Webel M.W., Ritts R.E., Taswell H.F., Donadio J.V., Swoods J.E. (1974) “Cellular immunity after intravenous administration of methylprednisolone”, J. Lab. Clin. Med. 83, 383–392.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Zuccarello, M., Zerbi, D., Macchia, G., Andrioli, G.C., Schmitt, G. (1991). Comparative Effects of Dexamethasone and Methylprednisolone on Peritumoral Brain Edema. In: Paoletti, P., Takakura, K., Walker, M.D., Butti, G., Pezzotta, S. (eds) Neuro-Oncology. Developments in Oncology, vol 66. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3152-0_45
Download citation
DOI: https://doi.org/10.1007/978-94-011-3152-0_45
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5390-7
Online ISBN: 978-94-011-3152-0
eBook Packages: Springer Book Archive