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The fine structural aspects of brain oedema and associated microvascular and glial changes

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Molecular Basis of Neurological Disorders and Their Treatment

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Abstract

The brain is unique among the various organs of the body in several ways. Perhaps the most obvious is its almost total confinement within the rigid, bony calvarium. Another well-known difference between the mature brain and many other organs is the blood-brain barrier, which somehow results in the poor penetration of certain molecules into the brain parenchyma that readily permeate most other tissues. The purpose of this presentation is to outline the fine structural alterations observed under various oedematous conditions. Particular attention will be paid to the endothelium of the small vessels of the brain and the surrounding cerebral parenchyma.

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References

  • Bearer, E.L., and Orci, L. (1985) J. Cell. Biol., 100, 418–28.

    Article  PubMed  CAS  Google Scholar 

  • Betz, A.L., Firth, J.A. and Goldstein, G.W. (1980) Brain Res., 192, 17–28.

    Article  PubMed  CAS  Google Scholar 

  • Brightman, M.W. (1989) in Implications of the Blood-Brain Barrier and its Manipulation, Vol. 1 (ed. E. A. Neuwelt), Plenum Medical. New York, pp. 53–83.

    Chapter  Google Scholar 

  • Brightman, M.W., Hori, M., Rapoport, S.I. et al. (1973) J. Comp. Neurol., 152, 317–26.

    Article  PubMed  CAS  Google Scholar 

  • Broadwell, R.D., Balin, B. and Salcman, M. (1988) Proc. Natl Acad. Sci. USA, 80, 7352–6.

    Article  Google Scholar 

  • Dorovini-Zis, K., Sato, M., Goping, G. et al. (1983) Acta Neuropathol. (Berl.), 60, 49–60.

    Article  PubMed  CAS  Google Scholar 

  • Hirano, A. (1974) in Pathology of Cerebral Microcirculation (ed. J. Cervos-Navarro), de Gruyter, Berlin, pp. 203–17.

    Google Scholar 

  • Hirano, A. (1982) Acta Neuropathol. (Berl,), 58, 34–8.

    Article  PubMed  CAS  Google Scholar 

  • Hirano, A. (1983) in Progress in Neuropathology, Vol. 5 (ed. H.M. Zimmerman), Raven Press, New York, pp. 99–112.

    Google Scholar 

  • Hirano, A. (1985) in Proceedings of the 6th International Symposium on Brain Edema (ed, Y. Inaba), Springer-Verlag, New York, pp. 6–13.

    Chapter  Google Scholar 

  • Hirano, A. (1987) in Stroke and Cerebrospinal Microcirculation (eds. J. Cervos-Navarro and R. Ferszt), Raven Press, New York, pp. 219–22.

    Google Scholar 

  • Hirano, A. and Dembitzer, H.M. (1982) J Neurocytol., 11, 861–6.

    Article  PubMed  CAS  Google Scholar 

  • Hirano, A. and Kato, T. (1988) in Neuromethod Vol. 9: Neuronal Microenvironment (eds A.A. Boulton, G.B. Baker and W. Walz), Human Press, Clifton, NJ, pp. 105–26.

    Chapter  Google Scholar 

  • Hirano, A. and Llena, J.F (1983) in Advances in Cellular Neurobiology, Vol. 4 (eds S. Federoff, S. and L. Herz), Academic Press, New York, pp. 223–47.

    Google Scholar 

  • Hirano, A. and Matsui, T. (1975) Human Pathol., 6, 611–21.

    Article  CAS  Google Scholar 

  • Hirano, A., Zimmerman, H.M. and Levine, S. (1964) Am. J. Pathol., 45, 1–19.

    PubMed  CAS  Google Scholar 

  • Hirano, A., Zimmerman, H.M. and Levine, S. (1965) J. Neuropathol. Exp. Neurol., 24, 386–97.

    Article  Google Scholar 

  • Hirano, A., Zimmerman, H.M. and Levine, S. (1968) J. Neuropathol. Exp. Neurol., 27, 571–80.

    Article  PubMed  CAS  Google Scholar 

  • Hirano, A., Becker, N.H. and Zimmerman, H.M. (1969) Arch. Neurol., 20, 300–8.

    Article  PubMed  CAS  Google Scholar 

  • Hirano, A., Llena, J.F. and Chung, H.D. (1975) Acta Neuropathol. (Berl.), 32, 103–13.

    Article  PubMed  CAS  Google Scholar 

  • Ikuta, F., Ohama, E., Yoshida, Y. et al. (1983) Adv. Neurol. Sci. (Tokyo), 27, 839–56.

    Google Scholar 

  • Kachar, B. and Reese, T.S. (1982) Nature (Lond.), 296, 464–6.

    Article  PubMed  CAS  Google Scholar 

  • Kato, S. and Nakamura, H. (1989) Acta Neuropathol. (Berl.), 77, 455–64.

    Article  PubMed  CAS  Google Scholar 

  • Labastie, M.C., Poole, T.J., Peault, B.M. and Le Douarin, N.M. (1986) Proc. Natl Acad, Sci. USA, 83, 9016–20.

    Article  CAS  Google Scholar 

  • Mickalak, T., White, F.P., Gard, A.L. and Dutton, G.R. (1986) Brain Res., 379, 320–8.

    Article  Google Scholar 

  • Nag, S. (1988) Acta Neuropathol. (Berl.), 75, 547–53.

    Article  PubMed  CAS  Google Scholar 

  • Nagy, Z., Peters, H. and Huttner, I. (1984) Lab. Invest., 50, 313–22.

    PubMed  CAS  Google Scholar 

  • Noguchi, Y., Shibata, Y. and Yamamoto, T. (1987) Anat. Rec., 217 355–60.

    Article  PubMed  CAS  Google Scholar 

  • Rapoport, S. and Robinson, P.J. (1986) Ann. NY Acad. Sci., 481, 250–67.

    Article  PubMed  CAS  Google Scholar 

  • Reese, T.S. and Karnovsky, M.J. (1967) J Cell. Biol., 34, 207–17.

    Article  PubMed  CAS  Google Scholar 

  • Schlingemann, R.O., Dingjan, G.M., Emeis, J.J. et al. (1985) Lab. Invest., 52, 71–6.

    PubMed  CAS  Google Scholar 

  • Simionescu, N., Simionescu, M. and Palade, G.E. (1981) J. Cell. Biol., 90, 605–13.

    Article  PubMed  CAS  Google Scholar 

  • Sternberger, N.H. and Sternberger, L.A. (1987) Proc. Natl. Acad. Sci. USA, 84, 8169–73.

    Article  PubMed  CAS  Google Scholar 

  • Vorbrodt, A.W., Lossinsky, A.S. and Wisniewski, H.K.M. (1982) Brain Res., 243, 225–34.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Neuropathology, Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York, 10467, USA

    A. Hirano & R. Waki

Authors
  1. A. Hirano
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  2. R. Waki
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Editors and Affiliations

  1. Chelsea Department of Pharmacy, King’s College London, University of London, Manresa Road, SW3 6LX, London, UK

    J. W. Gorrod

  2. Institute of Medical Biochemistry and Chemistry and Centre for the Study of Mitochondria and Energy Metabolism, University of Bari, Italy

    S. Papa

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© 1991 Springer Science+Business Media Dordrecht

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Hirano, A., Waki, R. (1991). The fine structural aspects of brain oedema and associated microvascular and glial changes. In: Gorrod, J.W., Albano, O., Ferrari, E., Papa, S. (eds) Molecular Basis of Neurological Disorders and Their Treatment. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3114-8_9

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  • DOI: https://doi.org/10.1007/978-94-011-3114-8_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5379-2

  • Online ISBN: 978-94-011-3114-8

  • eBook Packages: Springer Book Archive

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