Abstract
Ischaemic stroke is a primarily vascular disorder for which no uniformly successful treatment exists. The socioeconomic consequences of this disorder with the clinical approaches currently available are staggering in the negative: it is the second most common vascular cause of death in North America, and the third leading cause of death and disability in the Northern Hemisphere (Report of the Atherosclerosis Task Force, 1982; Mackay and Nias, 1979).
This research was supported in part by grant 1-R01-NS26945 from the National Institutes of Health. This is publication No. 6193-MEM from the Research Institute of Scripps Clinic, La Jolla, California
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aldrich, M.S., Sherman, S.A., Greenberg, H.S. et al. (1985) JAMA, 253, 1777–9.
Astrup, J., Symon, L., Branston, N.M. and Lassen, N. (1977) Stroke, 8, 51–7.
Bachman, F. and Kruithof, I.E.K.O. (1984) Semin. Thromb. Hemost., 10, 6–17.
Barnett, H.J.M. (1979) Med. Clin. North Am., 63, 649–79.
Barsan, W.G., Brott, T.G., Clinger, C.P. and Marler, J.R. (1989) Ann. Intern. Med., 111, 449–512.
Bewermeyer, H. Schumacher, A., Neveling, M. and Heirslo, D. (1984) Dtsch. Med. Wochenschr., 109, 1653–9.
Bloom, A.L. (1987) Haemostasis and Thrombosis, Churchill Livingstone, Edinburgh.
Braunwald, E., Knatterud, G.L., Passamani, E. (1987) J. Am. Coll. Cardiol., 10, 970.
Brott, T., Haley, E.L., Lew, D.E. (1988) Ann. Emerg. Med., 17, 1202–5.
Bruckmann, H. and Ferbert, A. (1989), 31, 95–7.
Buchweitz, E. and Weiss, H.R. (1986) Brain Res., 377, 105–11.
Collen, D., Rijken, D.C., Van Damme, J. and Billiau, A. (1982) Thromb. Haemost., 48, 294–6.
Cross, C.E., Halliwell, B., Borish, E.T. (1987) Ann. Intern. Med., 107, 526–45.
Dalal, P.M., Shah, P.M., Sheth, S.C. and Deshpande, C.K. (1965) Lancet, i, 61–4.
Del Zoppo, G.J. (1987) in New Trends in Diagnosis and Management of Stroke, (eds K. Poeck, E.B. Ringlstein et al.), Springer-Verlag, Berlin, p. 115–27.
Del Zoppo, G.J., Zeumer, H. and Harker, L.A. (1986a) Stroke, 17, 595–607.
Del Zoppo, G.J., Copeland, B.R., Harker, L.A. et al. (1986b) Stroke, 17, 638–43.
Del Zoppo, G.J., Ferbert, A., Otis, S.L. et al. (1988) Stroke, 19, 307–13.
Del Zoppo, G.J., Poeck, L., Pessin, M.S. et al. (1989) Thromb. Haemost. 62, 27.
DeWood, M.A., Spores, J., Notske, R. et al. (1980) N. Engl. J. Med., 303, 897–902.
Ehrlich, H.J., Bang, N.U., Little, S.P. et al. (1987) J. Fibrinolysis, 2, 75–81.
Ehrly, A. (1976) Angiology, 27, 188–96.
Fisher, C.M. and Adams, R.D. (1951) J. NeuropathoL Exp. Neurol., 10, 92–4.
Garcia, J.H. and Kamijyo, Y. (1974) J. Neuropathol. Exp. Neurol., 33, 408–21.
Garcia, J.H., Cox, J.V., Hudgins, W.R. et al. (1971) Arch. Neuropathol, 18, 273–85.
Garcia, J.H., Lowig, S.L., Briggs, L. et al. (1983) Cerebrovascular Diseases, (eds M. Reivich and H.I. Hartig) Raven Press, New York, pp. 169–79.
Gimbrone, M.A. Jr. (1986) in Vascular Endothelium in Hemostasis and Thrombosis (ed M.A. Gimbrone Jr), Churchill Livingstone, Edinburgh, pp. 1–13.
Hacke, W., Zeumer, H., Ferbert, A. et al. (1988) Stroke, 19, 1216–22.
Hermans, J. and McDonagh, J. (1982) Semin. Thromb. Hemost.,, 8, 11–24.
Hirschberg, M. and Hofferberth, B. (1987) Neurology, 37, 133.
ISIS-2 Collaborative Group (1988) Lancet, ii, 349–60.
Levin, E.G. (1986) Blood, 67, 1309–13.
Mackay, A. and Nias, B.C. (1979) J. R. Coll. Physicians Lond., 13, 106–12.
Marder, V.J. (1986) in Cerebrovascular Diseases: Fourteenth Research Conference (eds F. Plum and W.A. Pulsinelli), Raven Press, New York, p. 241–7.
Miyakawa, T. (1984) Rinsho Ketsueki, 25, 1018–26.
Mori, E., Tabuchi, M., Yoshida, T. and Yamadori, A. (1988) Stroke, 19, 802–12.
Nag, S. and Robertson, D.M. (1987) in Cerebral Blood Flow (ed. J.H. Wood). McGraw-Hill, New York, pp. 59–74.
Nenci, G.G., Gresele, P., Taramelli, M. et al. (1983) Angiology, 34, 561–71.
Passamani, E., Hodges, M., Herman, M. et al. (1987) J. Am. Coll. Cardiol., 10, 51B–64B.
Ranby, M. (1982), Biochem. Biophys. Acta, 704, 461–9.
Ranby, M., Bergsdorf, N. and Nilsson, T. (1982) Thromb. Res., 27, 175–83.
Rehncrona, S., Rosen, I. and Siessö, B. (1981) J. Cereb. Blood Flow Metab., 1, 297–311.
Reneman, R.S., van Merode, T., Smeets, F.A.M. and Hoeks, A.P.G. (1988) in Carotid Artery Plaques (eds M. Hennerici G. Sitzer and Weger, H.D.), Karger, Basel, pp. 143–62.
Report of the Atherosclerosis Task Force (1982) NIH Publication.
Rijken, D.C., Hoylaerts, M. and Collen, D. (1982a) J. Biol. Chem., 257, 2920–5.
Rosenberg, R.D. (1987) in The Molecular Basis of Blood (eds B. Stamatoyan-nopoulos, A.W. Neinhuis, P. Leder et al.), Saunders, Philadelphia, pp. 534–74.
Ross, R.T. (1977) Can. J. Neurol. Sct., 4, 143–50.
rt-PA Acute Stroke Study Group (1988) Stroke, 19, 134.
Schockley, R.P. and LaManna, J.C. (1988) Brain Res., 454, 170–8.
Schmid-Schonbein, H. and Wurzinger, L.J. (1988) in Carotid Artery Plaques (eds M. Hennerici, G. Sitzer and Weger, H.D.), Karger, Basel, pp. 64–91.
Solis, O.J., Robertson, G.R., Taderas, J.M. et al. (1977) Revist. Interam. Radial., 2, 19–25.
Spatz, M., Bauc, F., McCarron, K.M. et al, (1989) J. Cereb. Blood Flow Metab., 9, S393.
Spetzler, R.F., Selman, W.R., Weinstein, P. et al. (1980) J. Neurosurg., 7, 257–61.
Tevritti, V.T., Miggli, R. and Baumgartner, N.R. (1977) NYAcad. Sci., 2, 84–102.
Theron, J., Coutheoux, P., Casaseo, A. et al. (1989) Am. J. Neuroradiol., 10, 753–65.
Verstraete, M. (1986) Lancet, i, 397–401.
Verstraete, M. and Collen, D. (1986) Blood, 67, 1529–41.
von Kummer, R., Hutschenreuter, M., Wildemann, B. and Hacke, W. (1989) J. Cereb. Blood Flow Metab., 9 (suppl.) 5721.
Yamaguchi, T. (1989) (Abstract) Tokyo Satellite Symposium of XIIth Congress of the ISTH.
Zeumer, H., Ringelstein, E.B. and Hacke, W. (1983a) Fortschr. Roentgenstr., 139, 467–75.
Zeumer, H., Ringelstein, E.B., Hassell, M. et al. (1983b) Dtsch. Med. Wochenschr., 108, 1103–5.
Zeumer, H., Freilag, H.J., Grzyka, U. and Neunzig, H.P. (1989) Neuroradiology, 31, 336–40.
Zur, M. and Nemerson, Y. (1987) in Haemostasis and Thrombosis (eds A.L. Bloom and D.P. Thomas), Churchill Livingstone, Edinburgh, pp. 148–64.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Del Zoppo, G.J. (1991). Tissue plasminogen activator: acute thrombotic stroke. In: Gorrod, J.W., Albano, O., Ferrari, E., Papa, S. (eds) Molecular Basis of Neurological Disorders and Their Treatment. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3114-8_14
Download citation
DOI: https://doi.org/10.1007/978-94-011-3114-8_14
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5379-2
Online ISBN: 978-94-011-3114-8
eBook Packages: Springer Book Archive