Abstract
Due to the difficulty (Kühlbrandt, 1988) in obtaining appropriately diffracting crystals of the acetylcholine receptor (AChR), there is not yet precise information on the three-dimensional structure of this membrane protein at atomic resolution. Thus an understanding at the molecular level of the functioning of this channel-making protein relies heavily on the development of an appropriate model incorporating as well as possible the structural information deduced from a variety of experimental investigations. Such a model of the ion-channel part of the AChR has been developed recently in our laboratory (Furois-Corbin and Pullman, 1988, 1989a, 1989b; Pullman and Furois-Corbin, 1990), using the presently available structural data, together with theoretical calculations and computer-aided molecular modelling. An outline of this model is given below with a brief discussion of some of its implications.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Changeux, J.P. (1990) Fidia Research Foundation Neuroscience Award Lectures, Vol. 4, pp. 21–168.
Changeux, J.P. and Revah, F. (1987), TINS, 10, 245–9.
Furois-Corbin, S. and Pullman, A. (1988) in Transport through Membranes, Carriers, Channels and Pumps (21 st Jerusalem Symposium) (eds A. Pullman et al.), Kluwer, London, pp. 337–57.
Furois-Corbin, S. and Pullman, A. (1989a) Biochim. Biophys. Acta, 984, 339–50.
Furois-Corbin, S. and Pullman, A. (1989b) FEBS Lett., 252, 63–8.
Furois-Corbin, S. and Pullman, A. (1991) Biophysical Chemistry, 39, 153–9.
Giraudat, J., Dennis, M., Heidmann, T. et al. (1986) Proc. Nat. Acad. Sci, USA, 83, 2719–23.
Imoto, K., Busch, C., Sakmann, B. et al. Nature, 335, 645–8.
Kühlbrandt, W. (1988) Q. Rev. Biophys. 21, 429–77.
Numa, S. (1989) The Harvey Lectures, 83, 127–65.
Pullman, A. and Furois-Corbin, S. (1990) Sixth Conversation Biomol. Struct. Dyn., Vol. II, 11, 195–210.
Pullman, A., Furois-Corbin, S. and Andrade, A.M. (1990) in Modelling of Molecular Structure and Properties (proceedings of the 41st International Meeting on Physical Chemistry) (ed. J.L. Rivail) Elsevier, Amsterdam, 71, 527–39.
Toyoshima, C. and Unwin, N. (1988) Nature, 336, 347–60.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Pullman, A. (1991). Towards a molecular model of the acetylcholine receptor channel. In: Gorrod, J.W., Albano, O., Ferrari, E., Papa, S. (eds) Molecular Basis of Neurological Disorders and Their Treatment. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3114-8_1
Download citation
DOI: https://doi.org/10.1007/978-94-011-3114-8_1
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5379-2
Online ISBN: 978-94-011-3114-8
eBook Packages: Springer Book Archive