Abstract
Castleman’s disease (giant lymphoid hamartoma, angiofollicular mediastinal lymph node hyperplasia, angiomatous lymphoid hamartoma) was originally described as a localized benign mediastinal lymph node enlargement characterized by angiofollicular hyperplasia and interfollicular capillary proliferation (Castleman et al.. 1956). Since this first description, Keller et al. (1972) reported the occurrence of extrathoracic unifocal lymph node presentation of the disease and divided the lesion histologically into the hyaline vascular type and the plasma cell type. The hyaline vascular variant accounts for about 80% of cases and has a predilection for the mediastinum. It is usually asymptomatic. In contrast to the hyaline vascular type, the plasma-cell variant is frequently found outside the mediastinum and is often associated with systemic manifestations. A multicentric variant of the disease has also been described, regularly associated with systemic symptoms (systemic Castleman’s disease) (Frizzeria etal.. 1983).
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© 1992 J. M. Verley and K. H. Hollmann
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Verley, J.M., Hollmann, K.H. (1992). Castleman’s disease. In: Tumours of the Mediastinum. Current Histopathology, vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2994-7_8
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DOI: https://doi.org/10.1007/978-94-011-2994-7_8
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