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Carcinogens and Mutagens in the Diet

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Public Education on Diet and Cancer

Part of the book series: Developments in Oncology ((DION,volume 70))

Abstract

Doll and Peto (1981), in their review on ‘Quantitative Estimates of Avoidable Risks of Cancer’ state that “it may be possible to reduce US cancer death rates by practicable dietary means by as much as 35%”. This reduction results from a 90% reduction of deaths from stomach and large bowel cancer and a 50% reduction of cancer of the endometrium, gallbladder, pancreas and breast. The degree of uncertainty in this estimate is expected to be large, however, so that values between 10% and 70% are considered possible. The authors also indicate that “there is still no precise and reliable evidence as to exactly what dietary changes would be of major importance”.

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References

  • Anonymous (1991). Sweetener intakes. Fd Chem Toxic 29: 71–72.

    Article  Google Scholar 

  • Aebi H, Blumenthal A, Bohren-Hoerni M, Brubacher G, Frey U, Müller HR, Ritzel G, Stransky M (Hrsg) (1984). Zweiter Schweizerischer Ernährungsbericht, Huber, Bern, Switzerland.

    Google Scholar 

  • Aeschbacher HU (1991). Potential carcinogens in the diet. Mutat Res 259: 203–410.

    Article  Google Scholar 

  • Arnes BN, Profet M, Gold LS (1990). Dietary pesticides (99.99% all natural). Proc Natl Acad Sci (USA) 87: 7777–7781.

    Article  Google Scholar 

  • Arnes BN, Magaw R, Gold LS (1987). Ranking possible carcinogenic hazards. Science 236: 271–280.

    Article  Google Scholar 

  • Becher H, Wahrendorf J (1990). Variability of unit risk estimates under different statistical models and between different epidemiological data sets. In: Scientific Issues in Quantitative Cancer Risk Assessment, SH Moolgavkar (ed), Birkhäuser, Basel, Switzerland, pp 267–285.

    Chapter  Google Scholar 

  • Bronsch C (1987). Untersuchungen zur Exposition und zum renalen Ausscheidungsverhalten des Kunststoffweichmachers Di(2-ethylhehyl)phtalat (DEHP) beim Menschen. Thesis No 8459, Swiss Federal Institute of Technology, Zürich, Switzerland

    Google Scholar 

  • DFG Deutsche Forschungsgemeinschaft (1990). Ochratoxin A Vorkommen und toxikologische Bewertung. VCH Verlagsgesellschaft mbH, Weinheim, Germany.

    Google Scholar 

  • Dichter CR (1984). Risk estimates of liver cancer due to aflatoxin exposure from peanuts and peanut products. Fd Chem Toxicol 22: 431–437.

    Article  CAS  Google Scholar 

  • Doll R, Peto R (1981). The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.J Natl Cancer Inst. 66: 1191–1308.

    PubMed  CAS  Google Scholar 

  • Gold LS, Sawyer CB, Magaw R, Backman GM, de Veciana M, Levinson R, Hooper NK, Havender WR, Bernstein L, Peto R, Pike MC, Arnes BN (1984). A carcinogenic potency database of the standardized results of animals bioassays. Environ Health Perspect 58: 9–319.

    Article  PubMed  CAS  Google Scholar 

  • Gold LS, de Veciana M, Backman GM, Magaw R, Lopipero P, Smith M, Blumenthal M, Levinson R, Bernstein L, Ames BN (1986). Chronological supplement to the carcinogenic potency database: standardized results of animal bioassays published through December 1982. Environ Health Perspect 67: 161–200.

    Article  PubMed  CAS  Google Scholar 

  • Gold LS, Slone TH, Backman G, Magaw R, Costa MD, Lopipero P, Blumenthal M, Ames BN (1987). Second chronological supplement to the carcinogenic potency database: standardized results of animal bioassays published through December 1984 and by the National Toxicology Program through May 1986. Environ Health Perspect 74: 237–329.

    Article  PubMed  CAS  Google Scholar 

  • Ingram DM (1981). Trends in diet and breast cancer mortality in England and Wales 1928–1977. Nutr Cancer 3:75–80.

    Article  PubMed  CAS  Google Scholar 

  • Kramers PGN, Van Der Heijden CA (1988). Polycyclic aromatic hydrocarbons (PAH): carcinogenicity data and risk extrapolations. Toxicol Environ Chem 16: 341–351.

    Article  CAS  Google Scholar 

  • Lutz WK (1990a). Endogenous genotoxic agents and processes as a basis of spontaneous carcinogenesis. Mutat Res 238:287–295.

    Article  CAS  Google Scholar 

  • Lutz WK (1990b). Dose-response relationship and low dose extrapolation in chemical carcinogenesis. Carcinogenesis 11:1243–1247.

    Article  CAS  Google Scholar 

  • Lutz W, Poetzsch J, Schlatter J, Schlatter Ch (1991). The real role of risk assessment in cancer risk management. Trends Pharmacol Sei 12: 214–217.

    Article  CAS  Google Scholar 

  • Peers FG, Linsell CA (1977). Dietary aflatoxins and human primary liver cancer.Ann Nutr Alim 31:1005–1018.

    CAS  Google Scholar 

  • Perera F, Boffetta P (1988). Perspectives on comparing risks of environmental carcinogens.J Natl Cancer Inst 80:1282–1291.

    Article  CAS  Google Scholar 

  • Schlatter J, Lutz WK (1990). The carcinogenic potential of ethyl carbamate (ure- thane): risk assessment at human dietary exposure levels. Fd Chem Toxic 28: 205–211.

    Article  CAS  Google Scholar 

  • SFA (1991). Zahlen und Fakten zu Alkohol- und Drogenproblemen 1990/91. Schweizerische Fachstelle für Alkoholprobleme, Lausanne, Switzerland. ISBN 2–88183–027–7.

    Google Scholar 

  • Shephard SE (1991). Risikobeurteilung von N-Nitrosoverbindungen un deren Vorläufer in der Nahrung. Mitt Gebiete Lebensm Hyg 82:36–44.

    CAS  Google Scholar 

  • Stähelin HB, Lüthy J, Casabianca A, Monnier N, Müller HR, Schutz Y, Sieber R (Hrsg) (1991). Dritter Schweizerischer Ernährungsbericht. Bundesamt für Gesundheitswesen, Bern, Switzerland.

    Google Scholar 

  • Tannenbaum A (1944). The dependence of the genesis of induced skin tumors in the caloric intake during different stages of carcinogenesis. Cancer Res 4: 673–677.

    CAS  Google Scholar 

  • Tannenbaum A, Silverstone H (1953). Nutrition in relation to cancer. Adv Cancer Res 1:451–501.

    Article  PubMed  CAS  Google Scholar 

  • Voogd CE (1981). On the mutagenicity of nitroimidazoles. Mutat Res 86:243–277.

    Article  PubMed  CAS  Google Scholar 

  • Zimmerli B, Zimmermann H, Müller F (1982). Perchlorethylen in Lebensmitteln. Mitt Gebiete Lebensm Hyg 73: 71–81.

    CAS  Google Scholar 

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© 1992 Springer Science+Business Media Dordrecht

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Lutz, W.K., Schlatter, J. (1992). Carcinogens and Mutagens in the Diet. In: Benito, E., Giacosa, A., Hill, M.J. (eds) Public Education on Diet and Cancer. Developments in Oncology, vol 70. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2986-2_2

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  • DOI: https://doi.org/10.1007/978-94-011-2986-2_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5327-3

  • Online ISBN: 978-94-011-2986-2

  • eBook Packages: Springer Book Archive

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