Abstract
Two important insecticide target sites in the insect nervous system are the voltage-sensitive sodium channel and the GABA (γ-aminobutyric acid) receptor/chloride ionophore complex.1 The former molecule is a critical component of nerve excitation, mediating the transient inward flux of sodium ions during the nerve action potential. The latter mediates synaptic inhibition in response to GABA, the major inhibitory neurotransmitter of vertebrate and invertebrate nervous systems. Target site insensitivity to insecticidal compounds acting at these sites has been described and genetically isolated in a number of insect species.2 The isolation and characterization of the genes encoding these nerve membrane macromolecules in insects is, therefore, of critical importance for understanding the molecular basis of target site resistance mechanisms as well as the modes of action of insecticides in susceptible insects.
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Knipple, D.C., Doyle, K.E., Henderson, J.E., Soderlund, D.M. (1992). Isolation of Insect Genes Coding for Voltage-Sensitive Sodium Channels and Ligand-Gated Chloride Channels by PCR-Based Homology Probing. In: Duce, I.R. (eds) Neurotox ’91. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2898-8_19
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DOI: https://doi.org/10.1007/978-94-011-2898-8_19
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