Abstract
Cytologically visible damage in human chromosome detected as Sister Chromatid Exchanges (SCEs) or other structural chromosomal aberrations is one of the “In Vitro” steps to assess the biocompatibility of some materials to be used in orthopaedy or dentistry. The utility of these observations is that they point out that similar alterations may have occurred in other tissues, either somatic or germinal cells, evenience with possible clinical implications. The absence of effects on the DNA of replicating human lymphocytes cultivated in presence of three different types of Alumina (105 NS, 105 SFP and 130 SF, Metco Ind.) and an Hydroxyapatite, at different concentrations, let these materials to be classified as “negative”, (from the point of view of being a possible genotoxic substance), as they failed to induce a significant increase in SCEs. They result also not inducing effects on the proliferation rate index (PRI) on the same cell type.
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© 1992 Elsevier Science Publishers Ltd
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Cannas, M., Biasiol, S., Masse’, A., Ruggeri, A., Strocchi, R. (1992). Sister Chromatid Exchanges (SCEs) and Proliferation Rate Index (PRI): The Application of Cytogenetic Methods in Biocompatibility Field. In: Ravaglioli, A., Krajewski, A. (eds) Bioceramics and the Human Body. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2896-4_48
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DOI: https://doi.org/10.1007/978-94-011-2896-4_48
Publisher Name: Springer, Dordrecht
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