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Complement Activation by Ceramics

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Bioceramics and the Human Body

Abstract

The left ventricular assist device is based on the principle of the Maillard-Wenkel rotative pump. The materials which make up the pump must present particular mechanical, tribological, thermal and chemical properties. Graphite has been selected as a substrate, ceramic as the coating. The purpose of this study is to evaluate the in vitro complement activation eventually initiated by ceramic powders (A12O3, ZrO2/Y2O3, AIN, B4C, BN, SiC, Si3N4, TiB2, TiC, TiN), graphite and diamond. The morphology of powders has been studied by Scanning Electron Microscopy and X-Ray Diffraction investigations have been carried out. The evaluation of complement activation was undertaken by measuring the total hemolytic complement (CH50). No activation has been detected.

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References

  1. Montiès, J.R. and Havlik, P., Mechanical pump destined for left ventricular assist device and for total permanent cardiac replacement. Acta Cardiologica, 1982, Suppl. XXVIII, pp. 136–138.

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Author information

Authors and Affiliations

  1. INSERM U.306- Université de Bordeaux II, 146, rue Léo Saignat, F33076, Bordeaux, France

    Isabelle Dion & Charles Baquey

  2. Service d’Immunologie, Hôpital Pellegrin, Place Amélie Raba Léon, F33076, Bordeaux, France

    Anie Baquey & Monique Pourtein

  3. Laboratoire de Recherches Chirurgicales, Université Aix-Marseille II, 27 Boulevard Jean Moulin, F13385, Marseille-Cédex 5, France

    Thierry Mesana & Jean-Raoul Monties

  4. Teracor, ZI Toulon-Est, BP 238, F83089, Toulon Cédex, France

    Isabelle Dion & Bernard Candelon

Authors
  1. Isabelle Dion
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  2. Anie Baquey
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  3. Charles Baquey
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  4. Thierry Mesana
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  5. Monique Pourtein
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  6. Bernard Candelon
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  7. Jean-Raoul Monties
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Editor information

Editors and Affiliations

  1. Research Institute for Ceramic Technology, National Research Council, Faenza, Italy

    A. Ravaglioli  & A. Krajewski  & 

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© 1992 Elsevier Science Publishers Ltd

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Dion, I. et al. (1992). Complement Activation by Ceramics. In: Ravaglioli, A., Krajewski, A. (eds) Bioceramics and the Human Body. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2896-4_47

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  • DOI: https://doi.org/10.1007/978-94-011-2896-4_47

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-85166-748-2

  • Online ISBN: 978-94-011-2896-4

  • eBook Packages: Springer Book Archive

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