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Potential of Novel Chemical Approaches for Overcoming Insecticide Resistance

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Resistance ’91: Achievements and Developments in Combating Pesticide Resistance

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Abstract

Novelty in chemical approaches to pest control can provide an important contribution to Insecticide Resistance Management strategies. This novelty can take the form of insecticides with new modes of action, novel molecules not already resisted metabolically, or specifically controlled availability, all of which can be satisfied by purely synthetic chemical leads. Natural products could also be further exploited, but the fact that they are “natural” will not in itself circumvent resistance. Natural product leads fall mainly into three categories:- compounds that regulate internal processes and development of the pest organism, compounds involved in interactions between pests and the crop or other plants, and compounds employed by organisms that attack pest or related species. As well as giving rise to new toxic insecticides, natural product leads include compounds that affect development, or act as behavioural signals, e.g. the semiochemicals. Since these compounds arise from natural biosynthetic processes, they may be exploited by use of molecular biology, an approach not generally available for purely synthetic chemicals. Such approaches include the creation of transgenic crop plants able to generate products conferring defence against pests. Where semiochemicals are used in pest control, the sophisticated analytical methods now available should allow early identification of any related naturally occurring compounds, and thereby help in anticipating potential resistance problems.

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Authors and Affiliations

  1. Rothamsted Experimental Station, AFRC Institute of Arable Crops Research, Harpenden, Herts, AL5 2JQ, UK

    John A Pickett

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  1. John A Pickett
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  1. Rothamsted Experimental Station, Harpenden, Herts, UK

    Ian Denholm  & Alan L. Devonshire  & 

  2. Long Ashton Experimental Station, Bristol, UK

    Derek W. Hollomon

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Pickett, J.A. (1992). Potential of Novel Chemical Approaches for Overcoming Insecticide Resistance. In: Denholm, I., Devonshire, A.L., Hollomon, D.W. (eds) Resistance ’91: Achievements and Developments in Combating Pesticide Resistance. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2862-9_29

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  • DOI: https://doi.org/10.1007/978-94-011-2862-9_29

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-85166-886-1

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