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Potential for Synergising Herbicides through Modification of Metabolism

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Resistance ’91: Achievements and Developments in Combating Pesticide Resistance

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Abstract

There are numerous examples in the literature of herbicides whose species selectivity has been primarily attributed to differential metabolism. In addition, resistant weed biotypes (e.g. chlotoluron-resistant blackgrass (Alopecurus myosuroides) have emerged for which elevated metabolism appears to form the basis for the acquired resistance. Clearly, metabolism can play a key role in the response of a plant to the particular herbicide and, consequently, an ability to manipulate herbicide detoxification in weed species offers a potential opportunity for synergy. This may lead to a broadening of spectrum to include previously difficult to control species as well as synergistic mixtures for eradication of resistant biotypes. The present paper briefly outlines the key herbicide detoxification reactions responsible for species selectivities, with emphasis on oxidative reactions and glutathione conjugation and reference to the underlining biochemistry. Published literature on the modification of these degradative mechanisms by such mixed function oxidase inhibitors as 1-aminobenzotriazole (ABT), piperonyl butoxide, tetcyclacis and paclobutrazol (plant growth regulators), a number of azole fungicides and the herbicide tridiphane is reviewed. The effect of tridiphane on glutathione S-transferase mediated detoxification will also be discussed. Some comparisons between in vivo and in vitro results are made. Finally, some of the problems associated with the possible implementation and further exploitation of this approach to synergy are discussed, not least of which would be the need for selective synergists to avoid loss of crop selectivity.

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Authors and Affiliations

  1. Letcombe Laboratory, Letcombe Regis, DowElanco Ltd., Wantage, Oxon, OX12 9JT, UK

    W. John Owen

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  1. Rothamsted Experimental Station, Harpenden, Herts, UK

    Ian Denholm  & Alan L. Devonshire  & 

  2. Long Ashton Experimental Station, Bristol, UK

    Derek W. Hollomon

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Owen, W.J. (1992). Potential for Synergising Herbicides through Modification of Metabolism. In: Denholm, I., Devonshire, A.L., Hollomon, D.W. (eds) Resistance ’91: Achievements and Developments in Combating Pesticide Resistance. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2862-9_28

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  • DOI: https://doi.org/10.1007/978-94-011-2862-9_28

  • Publisher Name: Springer, Dordrecht

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