Skip to main content

Abstract

When emergence of resistance to one fungicide coincides with increased sensitivity to another chemical, it may be a case of negative cross-resistance. Examples are given for carboxamides, sterol C-14 demethylation inhibitors and benzimidazoles. The mechanisms of such negative relationships and their practical implications are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Leroux, P. La résistance des champignons aux fongicides, 1987, Phytoma, 385, 6-14 and 386, 31–35.

    Google Scholar 

  2. Georgopoulos, S.G. Development of fungal resistance to fungicides. In Antifungal compounds, eds. M.R., Siegel and H.D., Sisler. Marcel Dekker, New-York, 1977, 2, 439–495.

    Google Scholar 

  3. De Waard, M.A. Negatively correlated cross-resistance and synergism as strategies in coping with fungicide resistance. Br. Crop Prot. Conf. Pests and Dis., 1984, 89–95.

    Google Scholar 

  4. Kuhn, P.J. Mode of action of carboxamides. In Mode of action of antifungal agents, eds. A.P.J., Trinci and J.F. Riley. Cambridge University Press, Cambridge, 1984, pp. 155–183.

    Google Scholar 

  5. White, G.A., Thorn, G.D. and Georgopoulos, S.G. Oxathiin carboxamides highly active against carboxin resistant succinate dehydrogenase complexes from carboxin-selected mutants of Ustilago maydis and Aspergillus nidulans. Pestic. Biochem. Physiol, 1978, 9, 176–182.

    Article  Google Scholar 

  6. White, G.A. Substituted benzanilides: structural variations and inhibition of complex II activity in mitochondria from a wild-type strain and a carboxin-selected mutant strain of Ustilago maydis. Pestic. Biochem. Physiol., 1987, 27, 249–260

    Article  CAS  Google Scholar 

  7. White, G.A. Furan carboxamide fungicides: structure-activity relationships with the succinate dehydrogenase complex in mitochondria from a wild-type strain and a carboxin-resistant mutant strain of Ustilago maydis. Pestic. Biochem. Physiol., 1988, 31, 129–145.

    Article  CAS  Google Scholar 

  8. Leroux, P. and Berthier, G. Resistance to carboxin and fenfuram in Ustilago nuda, the causal agent of barley loose smut. Crop Protec., 1988, 7, 16–19.

    Article  CAS  Google Scholar 

  9. Leroux, P. and Berthier, G. Phenomènes de résistance du charbon nu de l’orge (Ustilago nuda) à la carboxine et au fenfurame. 2nd International Conference on Plant Disease, Annale ANPP, Paris, 1988, 1283–1291.

    Google Scholar 

  10. Hollomon, D.W. and Carter, G.A. Resistance within U.K. isolates of Ustilago nuda to carboxanilide fungicides. ISPP, Chemical control Newsletter, 1989, 12, 37–39.

    Google Scholar 

  11. Koller, W. Sterol demethylation inhibitors: mechanism of action and resistance. In Fungicide resistance in North America, ed. C.J. Delp, APS Press, St. Paul., 1988, pp. 79–88.

    Google Scholar 

  12. Leroux, P. and Benveniste, P. Mode d’action des fongicides inhibiteurs des stérols. In Proc. Bordeaux Mixture Centenary Meeting, BCPC monograph n° 31, 1985, pp. 67–78.

    CAS  Google Scholar 

  13. Kendall, S.G. Cross-resistance of triadimenol-resistance fungal isolates to other C-14 demethylation inhibitors fungicides. Br. Crop Prot. Conf. Pests and Dis., 1986, 539–546.

    Google Scholar 

  14. Leroux, P. Gredt, M. and Boeda, P. Resistance to inhibitors of sterol biosynthesis in field isolates or laboratory strains of the eyespot pathogen Pseudocercosporella herpotrichoides, Pestic. Sci., 1988, 23, 119–129.

    Article  CAS  Google Scholar 

  15. Nuninger-Ney, C., Schwinn, F.J. and Staub, T. In vitro selection of sterol-biosynthesis inhibitor (SBI) resistant mutants in Monilinia fructicola. Neth. J. Pl. Path., 1989, 137–150.

    Google Scholar 

  16. Krämer W., Berg, D. and Koller W. Chemical synthesis and fungicide resistance. In Combating Resistance to xenobiotics, ed. M.G., Ford, D.W. Hollomon, B.P.S. Khambay and R.M. Sawicki. VCH, Horwood, Chichester, 1987, pp. 291–305.

    Google Scholar 

  17. Akallal, R. Résistance de Fusarium solani f. sr. piSi, à des fongicides inhibant la C-14 déméthylation des stérols. Thèse, Université de Paris Sud, France 1989, 136 p.

    Google Scholar 

  18. Kalamarakis, A.E., Demopoulos, V.P., Ziogas B.N. and Georgopoulos, S.G. A highly mutable major gene for triadimenol resistance in Nectria haematoccoca var. cucurbitae. Neth J. Pl. Path. 1989, 95, 109–120.

    Article  CAS  Google Scholar 

  19. Leroux, P. et Marchegay P. Caractérisation des souches de Pseudocercosporella herpotrichoides, agent du piétin-verse des céréales, résistantes au prochloraze, isolées en France sur blé tendre d’hiver. Agronomie, 1991 (submitted).

    Google Scholar 

  20. Stéva, H. et Clerjeau, M. Cross-resistance to sterol biosynthesis inhibitor fungicides in strains of Uncinula necator isolated in France and Portugal. Med. Fac. Landbouww Rijksuniv. Gent, 1990, 55, 983–988.

    Google Scholar 

  21. Fuchs, A. Implications of stereoisomerism in agricultural fungicides. In Stereoselectivity of pesticides, ed. E.J. Ariëns, J.J.S. Van Rensen and W. Welling. Elsevier, Amsterdam, 1988, pp. 203–262.

    Google Scholar 

  22. Berg, D., Born, L., Büchel, K.H., Holmwood, G. and Kaulen J. HWG 1608-Chesmistry and Biochemistry of a new azole fungicide. Pflanzen schutz. Nachrichten Bayer, 1987, 40, 111–132.

    CAS  Google Scholar 

  23. Hollomon, D.W. Molecular approaches to understanding the mechanisms of fungicide resistance. Brighton Crop Prot. Coni. Pests and Dis., 1990, 881–888.

    Google Scholar 

  24. Barug, D. and Kerkenaar, A. Resistance in mutagen-induced mutants of Ustilago maydis to fungicides which inhibit ergosterol biosynthesis. Pestic. Sci., 1984, 15, 78–84.

    Article  CAS  Google Scholar 

  25. De Falandre, A., Bouvier, I. Seng, J.M. and Leroux, P. Induction and characterization of Penicillium caseicolum mutants resistant to ergosterol biosynthes is inhibitors. Appl. Environ. Microbiol., 1987, 53, 1500–1503.

    PubMed  CAS  Google Scholar 

  26. Brent, K.J., Carter, G.A., Hollomon, D.W., Hunter, T., Locke, T. and Proven, M. Factors affecting build-up of fungicide resistance in powdery mildew in spring barley. Neth. J. Pl. Path., 1989, 95, 31–41.

    Article  CAS  Google Scholar 

  27. Hollomon, D.W. Antifungal activity of substituted 2-aminopyrimidines. In Mode of action of antifungal agents. ed. A.P.J. Trinci and J.F. Riley Cambridge University Press, Cambridge, 1984, pp. 185–205.

    Google Scholar 

  28. Butters, J.A., Clark, J. and Hollomon, D.W. Resistance to inhibitors of sterol biosynthesis in barley powdery mildew. Med. Fac. Landbouww. Rijksuniv. Gent, 1984, 49, 143–151.

    CAS  Google Scholar 

  29. Hollomon, D.W. Genetic control of ethirimol resistance in a natural population of Erysiphe graminis f. sp. hordei. Phytopathology, 1981, 71, 536–540.

    Article  CAS  Google Scholar 

  30. Hollomon, D.W., Butters, J.A. and Clark, J. Genetic control of triadimenol resistance in barley powdery mildew. Br. Crop. Prot. Conf. Pests. and Dis., 1984, 477–482.

    Google Scholar 

  31. Davidse, L.C. Benzimidazole fungicides mechanism of action and biological impact. Ann. Rev. Phytopathol., 1986, 24, 43–65.

    Article  CAS  Google Scholar 

  32. Leroux, P. and Gredt, M. Negative cross-resistance of benzimidazoleresistance strains of Botrytis cinerea, Fusarium nivale and Pseudocercosporella herpotrichoides to various pesticides. Neth. J. Pl. Path., 1989, 95, 121–127.

    Article  CAS  Google Scholar 

  33. Nakata, A., Sano, S., Hashimoto, S., Hayakawa, K., Nishikawa, H. and Yasuda, Y. Negatively correlated cross-resistance to N-phenylformamidoximes in benzimidazole-resistant phytopathogenic fungi. Ann. Phytopath. Soc., Japan, 1987, 53, 659–662.

    CAS  Google Scholar 

  34. Ishii, H. and Takeda, H. Differential binding of a N-phenylformamidoxime compound in cell-free extracts of benzimidazole-resistant andsensitive isolates of Venturia nashicola, Botrytis cinerea and Fusarium fujikuroi. Neth. J. Pl. Path., 1989, 95,99–108.

    Article  CAS  Google Scholar 

  35. Groves, J.D., Fox, R.T.V. and Baldwin, B.C. Mode of action of carbendazim and ethyl N-(3,5-dichlorophenyl) carbamate on field isolates of Botrytis cinerea. Brighton Crop. Prot. Conf. Pests and Dis., 1988, 397–402.

    Google Scholar 

  36. Suzuki, K., Kato, T., Takahashi, J. and Kamoshita, K. Mode of action of methyl N-(3,5-dichlorophenyl) carbamate in the benzimidazole-resistant isolate of Botrytis cinerea, J. Pesticide Sci., 1984, 9, 497–501.

    CAS  Google Scholar 

  37. Fujimura, M. Oeda, K., Inoue, H. and Kato, T. Mechanism of action of N-phenylcarbamates in benzimidazole-resistant Neurospora strains. In Managing Resistance to Agrochemicals: from fundamental research to practical strategies. ed. M.B., Green, H.M., Lebaron and W.K., Moberg. ACS Symposium Series 421, Washington, 1990, 224–236.

    Google Scholar 

  38. Orbach, M.J., Porro, E.B. and Yanofsky, C. Cloning and characterization of the gene for-tubulin from a benomyl-resistant mutant of Neurospara crassa and its use as a dominant selctable marker. Moll. Cell Biol., 1986, 6, 2452–2461.

    CAS  Google Scholar 

  39. Demakopoulou, M.G. and Georgopoulos, S.G. Sensitivity to N-phenylcarbamates as related to benzimidazole resistance in Cercospora beticola. 6th IUPAC Congress, Ottawa, Canada, 1986, 3E-05 (Abs).

    Google Scholar 

  40. Leroux, P., Gredt, M., Massenot, F. and Kato, T. Activité du phényl-carbamate S 32165 sur Botrytis cinerea, agent de la pourriture grise de la vigne. In Proc. Bordeaux Mixture Centenary Meeting, BCPC monograph n° 31, 1985, pp. 443–446.

    CAS  Google Scholar 

  41. Rosenberger, D.A. and Meyer, F.W. Negatively correlated cross-resistance to diphenylamine in benomyl-resistant Penicillium expansum. Phytopathology, 1985, 75, 74–79.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 SCI

About this chapter

Cite this chapter

Leroux, P. (1992). Negative Cross-Resistance in Fungicides: From the Laboratory to the Field. In: Denholm, I., Devonshire, A.L., Hollomon, D.W. (eds) Resistance ’91: Achievements and Developments in Combating Pesticide Resistance. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2862-9_15

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-2862-9_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-85166-886-1

  • Online ISBN: 978-94-011-2862-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics