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Diabetes and Atherosclerosis pp 203–217Cite as

The Possible Role of Glycation in the Pathogenesis of Atherosclerosis

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 125))

Abstract

Hyperglycaemia is the hallmark of diabetes mellitus. Indeed, it is by measurement of the blood glucose that we diagnose and define the condition [1, 2]. In practice, raised blood glucose is the biochemical abberation in diabetes which, either by modification of diet or administration of oral hypoglycaemic drugs or insulin injection, is most responsive to therapeutic intervention. Because of the constancy of hyperglycaemia as a finding in untreated diabetes it is natural to speculate that excessive levels of glucose are in some way responsible for any or all of the ills which may subsequently befall diabetic patients. Our ability to manipulate the blood glucose towards normal adds attractiveness to this hypothesis, as both the patient and the attending physician will be encouraged to believe that their successful therapeutic endeavours, easily demonstrated by simple blood tests, will yield handsome long-term dividends. And our realization that it is almost impossible, in the majority of patients, to achieve complete normalization of the blood glucose provides the rationale (and intellectual consolation to the physician at least) when our best efforts fail to prevent the relentless onslaught of vascular complications.

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Authors
  1. Laurence Kennedy
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Editors and Affiliations

  1. The Queen’s University of Belfast, Belfast, Northern Ireland, UK

    Robert W. Stout (Professor of Geriatric Medicine and Dean of the Faculty of Medicine) (Professor of Geriatric Medicine and Dean of the Faculty of Medicine)

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Kennedy, L. (1992). The Possible Role of Glycation in the Pathogenesis of Atherosclerosis. In: Stout, R.W. (eds) Diabetes and Atherosclerosis. Developments in Cardiovascular Medicine, vol 125. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2734-9_9

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  • DOI: https://doi.org/10.1007/978-94-011-2734-9_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5212-2

  • Online ISBN: 978-94-011-2734-9

  • eBook Packages: Springer Book Archive

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