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Diabetes and Atherosclerosis pp 255–265Cite as

Non-Ischaemic Heart Disease in Diabetes Mellitus

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 125))

Abstract

The relationship between diabetes and cardiovascular disease is complex. Diabetes is an independent risk factor for atherosclerosis [1] and is associated with other risk factors for atherosclerosis such as hypertension [2] and hyperlipidaemia [1]. Thus the incidence of acute myocardial infarction is increased in diabetic patients [3, 4]. However not only is the incidence increased but the outcome of myocardial infarction is worse in diabetic patients with a mortality of twice that of the non-diabetic population [5–7]. Several studies have indicated that this increased mortality is associated with an increase in the incidence of cardiac failure complicating myocardial infarction in diabetes [6–8] with no excess of other complications. While this raises the possibility that diabetic subjects may have a greater infarct size due to more extensive atherosclerosis as the mechanism responsible for the increased mortality a number of studies using enzyme estimation of infarct size have failed to demonstrate larger infarcts in the diabetic group [6, 8, 9]. Other factors such as evidence of previous myocardial infarction or the presence of hypertension might account for the increased risk but studies where these factors have been controlled continue to demonstrate increased mortality associated with cardiac failure in those with diabetes [8, 10]. Observations such as these have led to the view that diabetes may contribute to heart disease by mechanisms independent of coronary artery disease.

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Authors
  1. J. Randal Hayes
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Editors and Affiliations

  1. The Queen’s University of Belfast, Belfast, Northern Ireland, UK

    Robert W. Stout (Professor of Geriatric Medicine and Dean of the Faculty of Medicine) (Professor of Geriatric Medicine and Dean of the Faculty of Medicine)

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© 1992 Springer Science+Business Media Dordrecht

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Hayes, J.R. (1992). Non-Ischaemic Heart Disease in Diabetes Mellitus. In: Stout, R.W. (eds) Diabetes and Atherosclerosis. Developments in Cardiovascular Medicine, vol 125. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2734-9_12

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  • DOI: https://doi.org/10.1007/978-94-011-2734-9_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5212-2

  • Online ISBN: 978-94-011-2734-9

  • eBook Packages: Springer Book Archive

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