Abstract
This paper presents studies of the temporal development of memory traces in the brain using relative metabolic activity methodologies with (14C)-2-deoxyglucose (2-DG) to sample long time-frames (40 min) or (14C)-glucose to capture shorter-lived phenomena (5 min). During the early consolidation period, labelling increases were observed in subcortical areas while much smaller increases were found in cortical areas. Late memory processes were associated with large labelling increases in cortical areas while intermediate delays were associated with an overall decline in labelling. When a task was completely mastered, both the early increase and the intermediate decrease were observed but the late cortical activation was absent. The patterns of metabolic activations observed after learning a new task are consistent with the incorporation of new informations within the central nervous system. Methodological requirements and limits of the combination of behavioral tests and the relative metabolic method using either glucose or 2-DG are discussed.
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Destrade, C., Messier, C., Bontempi, B., Sif, J., Jaffard, R. (1992). Investigations into Time-Dependent Metabolic Changes During Memory Processing in the Mouse Brain Using (14C) Deoxyglucose and (14C)-Glucose.. In: Gonzalez-Lima, F., Finkenstädt, T., Scheich, H. (eds) Advances in Metabolic Mapping Techniques for Brain Imaging of Behavioral and Learning Functions. NATO ASI Series, vol 68. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2712-7_15
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DOI: https://doi.org/10.1007/978-94-011-2712-7_15
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