Abstract
The spatial distribution and time profile of functional activation of central nervous system regions during acute formalin pain have been investigated with 14C-2-deoxyglucose (2-DG) methods in unanesthetized, freely-moving rats. In the early phase after subcutaneous formalin injection into a forepaw bilateral increases of the 2-DG uptake have been found in spinal cord and brainstem, diencephalic, and cortical structures, which may be involved in processing noxious information. Brainstem and diencephalic centers which are likely to take part in endogenous antinociceptive systems were also activated. The spatial extent and intensity of these functional changes blunted over time in most regions, in parallel with pain-related behavior.
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Porro, C.A., Cavazzuti, M. (1992). Functional Correlates of Acute Prolonged Pain in the Rat Central Nervous System: 2-DG Studies. In: Gonzalez-Lima, F., Finkenstädt, T., Scheich, H. (eds) Advances in Metabolic Mapping Techniques for Brain Imaging of Behavioral and Learning Functions. NATO ASI Series, vol 68. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2712-7_12
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