Abstract
It appears that some kind of “ammonium repression” occurs in many antibiotic fermentations when ammonium is supplied in excess. Decreased antibiotic synthesis with ammonium or other rapidly utilizable nitrogen sources and the relevance of nitrogen metabolism to production of secondary metabolites has been well documented ∣1, 2∣.
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References
Aharonowitz, Y. (1980) ‘Nitrogen metabolite regulation of antibiotic biosynthesis’, Annual Review of Microbiology 34, 209–233.
Brana, A.F., Wolfe, S. and Demain, A.L. (1985) ‘Ammonium repression of cephalosporin production by Streptomyces clavuligerus. Canadian J. Microbiology 31, 736–743.
Özcengiz, G., Alaeddinoğlu, N.G. and Demain, A.L. (1990) ‘Regulation of biosynthesis of bacilysin by Bacillus subtilis, J. Industrial Microbiology 6, 91–100.
Öcengiz, G. and Alaeddinoğlu, N.G. (1991) ‘Bacilysin production by Bacillus subtilis:Effects of bacilysin, pH and temperature’, Folia Microbiologica, in press.
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© 1992 Springer Science+Business Media Dordrecht
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Özcengiz, G., Alaeddinoğlu, N.G., Demain, A.L. (1992). Control by Nitrogenous Compounds of Bacilysin Production. In: Vardar-Sukan, F., Sukan, Ş.S. (eds) Recent Advances in Biotechnology. NATO ASI Series, vol 210. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2468-3_36
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DOI: https://doi.org/10.1007/978-94-011-2468-3_36
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