Skip to main content
SpringerLink
Log in

Myocardial perfusion and krypton-81m

  • Chapter
What’s New in Cardiac Imaging?

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 133))

  • 82 Accesses

Abstract

In humans, myocardial ischemia may be induced by various different mechanisms. Besides the classic concept of a disturbed ratio between myocardial oxygen demand versus supply, whereby a fixed epicardial coronary stenosis prevents sufficient oxygen and substrate supply to the heart in relation to its instantaneous need, abnormal coronary vasomotor regulation may significantly affect myocardial perfusion and oxygen supply irrespective of demand. Such abnormalities in vasomotor control may range from severe vasospasm to merely reduced coronary vasodilatation following an appropriate stimulus. Moreover, abnormal vasomotor regulation is not restricted to severe coronary lesions, but may also occur in apparently normal epicardial arteries or microvessels when hypercholesterolemia is present.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jones T, Clark JC. A cyclotron produced 81Rb-81m Kr generator and its uses in gammacamera studies. Br J Radiol 1969; 42: 237.

    Article  PubMed  CAS  Google Scholar 

  2. Yano Y, Anger HO. Ultrashort-lived radioisotopes for visualizing blood vessels and organs. J Nucl Med 1969; 9: 2–6.

    Google Scholar 

  3. Colombetti LG, Mayron LW, Kaplan E, Barnes WE, Friedman AM, Gindler JE. Continuous radionuclide generation. I. Production and evaluation of a 81m Kr minigenerator. J Nucl Med 1974; 15: 868–73.

    PubMed  CAS  Google Scholar 

  4. Guillaume M, Czichisz R, Richard P, Fagard E. Krypton-81m generator for ventialtion and perfusion. Dosimetry, routine production, methodology for medical applications. Bull Soc Sci Lièges 1983; 52: 214–81.

    Google Scholar 

  5. Schroth HJ, Bialy J, Hans FJ et al. Bestimmung des zerebralen Blutflusses mittels des 81Rb/81mKr-Generatorsystems. Nuklearmedizin 1990; 29: 7–12.

    PubMed  CAS  Google Scholar 

  6. Oliver RM, Gray JM, Challenor VF, Fleming JS, Waller DG. 81mKr equilibrium radionuclide ventriculography for the assessment of right heart function. Eur J Nucl Med 1990; 16: 89–95.

    Article  PubMed  CAS  Google Scholar 

  7. Caplin JL, Flatman WD, Dymond DS. Gated right ventricular studies using krypton-81m: comparison with first-pass studies using gold 195-m. J Nucl Med 1986; 27: 602–8.

    PubMed  CAS  Google Scholar 

  8. Zicot M, Guillaume M, Ham H, Redote R. Dynamic isotopic phlebography using soluble krypton-81m. Eur J Nucl Med 1986; 12: 192–6.

    Article  PubMed  CAS  Google Scholar 

  9. Hicks IP, Barter SJ, Carr DH, Joyce H, Pride NB, Lavender JP. Abnormal regional distribution of ventilation in middle-aged smokers: comparison of changes in 81Krm ventilation scans and computed tomography of the lung. Clin Radiol 1990; 41: 347–52.

    Article  PubMed  CAS  Google Scholar 

  10. Kety SS. The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 1951; 3: 1–41.

    PubMed  CAS  Google Scholar 

  11. Kaplan E, Mayron LW, Friedman AM et al. Definition of myocardial perfusion by continuous infusion of krypton-81m. Am J Cardiol 1976; 37: 878–84.

    Article  PubMed  CAS  Google Scholar 

  12. Turner JH, Selwyn AP, Jones T, Evans TR, Raphael MJ, Lavender JP. Continuous imaging of regional myocardial blood flow in dogs using krypton-81m. Cardiovasc Res 1976; 10: 398–404.

    Article  PubMed  CAS  Google Scholar 

  13. Selwyn AP, Jones T, Turner JH, Pratt T, Clark J, Lavender P. Continuous assessment of regional myocardial perfusion in dogs using krypton-81m. Circ Res 1978; 42:771–7.

    Article  PubMed  CAS  Google Scholar 

  14. Selwyn AP, Steiner R, Kivisaari A, Fox KM, Forse G. Krypton-81m in the physiologic assessment of coronary artery stenosis in man. Am J Cardiol 1979; 43: 547–53.

    Article  PubMed  CAS  Google Scholar 

  15. Selwyn AP, Forse G, Fox KM, Jonathan A, Steiner P. Patterns of disturbed myocardial perfusion in patients with coronary artery disease. Circulation 1981; 64: 83–90.

    Article  PubMed  CAS  Google Scholar 

  16. Remme WJ, Cox PH, Krauss XH, Kruijssen HACM, Storm CJ, Van Hoogenhuyze DCA. Visualization of myocardial blood-flow changes with intracoronary 81mKr. In: Biersack HJ, Cox PH, editors, Radioisotope studies in cardiology. Dordrecht, The Netherlands: Martinus Nijhoff 1985: 263–8.

    Google Scholar 

  17. Remme WJ, Cox PH, Krauss XH. Continuous myocardial bloodflow distribution imaging in man with krypton 81m intracoronary [abstract]. Am J Cardiol 1982; 49: 979.

    Google Scholar 

  18. Remme WJ, Kruijssen HA, Cox PH, Krauss XH. Assessment of functionally significant coronary artery disease during continuous intracoronary administration of krypton-81m [abstract]. Eur Heart J 1983; 4 Suppl E: 32.

    Google Scholar 

  19. Remme WJ, Cox PH, Krauss XH, Van der Kemp P, Storm CJ, Van Hoogenhuyze DCA. Continuous myocardial blood flow imaging with krypton-81m selective intracoronary. In: Salvatore M, Porta E, editors, Radioisotopes in cardiology. New York: Plenum Press 1983: 155–63.

    Google Scholar 

  20. Remme WJ, Krauss XH, Van Hoogenhuyze DCA, Cox PH, Storm CJ, Kruijssen HACM. Continuous determination of regional myocardial blood flow with intracoronary krypton-81m in coronary artery disease. Am J Cardiol 1985; 56: 445–51.

    Article  PubMed  CAS  Google Scholar 

  21. Remme WJ, Van Hoogenhuyze DCA, Krauss XH, Hofman A, Kruijssen HACM, Storm CJ. Acute hemodynamic and antiischemic effects of intravenous amiodarone. Am J Cardiol 1985; 55: 639–44.

    Article  PubMed  CAS  Google Scholar 

  22. Selwyn AP, Allan RM, l’Abbata A et al. Relation between regional myocardial uptake of rubidium-82 and perfusion: absolute reduction of cation uptake in ischemia. Am J Cardiol 1982; 50: 112–21.

    Article  PubMed  CAS  Google Scholar 

  23. Remme WJ, Van de Berg MD, Mantel M et al. Temporal relation of changes in regional coronary flow and myocardial lactate and nucleoside metabolism in humans during pacinginduced ischemia. Am J Cardiol 1986; 58: 1188–94.

    Article  PubMed  CAS  Google Scholar 

  24. Remme WJ, De Jong JW, Verdouw PD. Effects of pacing induced myocardial ischemia on hypoxanthine efflux from the human heart. Am J Cardiol 1977; 40: 55–62.

    Article  PubMed  CAS  Google Scholar 

  25. Remme WJ. Myocardial ischemia: a profile of its pathophysiological basis and its detection by nuclear cardiology. In: Biersack HJ, Cox PH, editors, Radioisotope studies in cardiology. Dordrecht, The Netherlands: Martinus Nijhoff 1985: 3–48.

    Chapter  Google Scholar 

  26. Remme WJ, Krauss XH, Storm CJ, Kruijssen H ACM, Van Hoogenhuyze DCA. Improved assessment of lactate production during pacing induced ischemia [abstract]. J Moll Cell Cardiol 1981; 13 suppl 1:76.

    Google Scholar 

  27. Remme WJ, Kruijssen HACM, Krauss XH, Storm CJ, Van Hoogenhuyze DCA. Myocardial metabolism during pacing-induced ischemia in man. Temporal relationship with changes in post-stenotic coronary flow. In: Mohl W, Faxon D, Wolner E, editors, Progress in coronary sinus interventions. Vol II. Darmstadt: Clinics of CSI, Steinkopff 1986.

    Google Scholar 

  28. Olsson RA. Changes in content of purine nucleoside in canine myocardium during occlusion. Circ Res 1970; 26: 301–6.

    Article  PubMed  CAS  Google Scholar 

  29. Fox AC, Reed GE, Glassman E, Kaltman AJ, Silk BB. Release of adenosine from human hearts during angina induced by rapid atrial pacing. J Clin Invest 1974; 53: 1447–57.

    Article  PubMed  CAS  Google Scholar 

  30. Ganz W, Tamura K, Marcus HS, Donoso R, Yoshida S, Swan HJC. Measurement of coronary sinus blood flow by continuous thermodilution in man. Circulation 1971; 44:181–95.

    Article  PubMed  CAS  Google Scholar 

  31. Weisse AB, Regan TJ. A comparison of thermodilution, coronary sinus blood flows and krypton myocardial blood flows in the intact dog. Cardiovasc Res 1974; 8: 526–33.

    Article  PubMed  CAS  Google Scholar 

  32. Rau G. Messung der Koronardurchblutung mit der Argon-Femdgasmethode. Tierexperimenten und Untersuchungen am Patienten bei niedriger und hoher Durchblutung. Arch Kreislaufforsch 1969; 58: 322–98.

    Article  PubMed  CAS  Google Scholar 

  33. Tauchert M, Kochsiek K, Heiss HW, Rau G, Bretschneider HJ. Technik der Organdurchblutungsmessung mit der Argon-methode. Z Kreislaufforsch 1971; 60: 871–80.

    PubMed  CAS  Google Scholar 

  34. Pepine CJ, Mehta J, Webster WW, Nichols WW. In vivo validation of a thermodilution method to determine regional left ventricular blood-flow in patients with coronary disease. Circulation 1978; 58: 795–802.

    Article  PubMed  CAS  Google Scholar 

  35. Feldman RL, Pepine CJ, Whittle JL, Curry RC, Conti CR. Coronary hemodynamic findings during spontaneous angina in patients with variant angina. Circulation 1981; 64: 76–82.

    Article  PubMed  CAS  Google Scholar 

  36. Domenech RJ, Hoffman JI, Noble MI, Saunders KB, Henson JR, Subijanto S. Total and regional coronary blood flow measured by radioactive microspheres in conscious and anesthetized dogs. Circ Res 1969; 25: 581–96.

    Article  PubMed  CAS  Google Scholar 

  37. Ashburn WL, Braunwald E, Simon AL, Peterson KL, Gault JH. Myocardial perfusion imaging with radioactive labeled particles injected directly into the coronary circulation of patients with coronary artery disease. Circulation 1971; 44: 581–96.

    Article  Google Scholar 

  38. Weller DA, Adolph RJ, Wellman NH, Caroll RG, Kim O. Myocardial perfusion scintigraphy after intracoronary injection of 99m Tc-labeled human albumin microspheres. Circulation 1972; 46: 963–75.

    Article  PubMed  CAS  Google Scholar 

  39. Bergmann SR, Fox KAA, Rand AL et al. Quantification of regional myocardial blood flow in vivo with H2 15O. Circulation 1984; 70: 724–33.

    Article  PubMed  CAS  Google Scholar 

  40. Schelbert HR, Phelps ME, Hoffman EJ, Huang SC, Selin CE, Kuhl DE. Regional myocardial perfusion assessed with N-13 labelled ammonia and positron emission computerized axial tomography. Am J Cardiol 1979; 43: 209–18.

    Article  PubMed  CAS  Google Scholar 

  41. Budinger TF, Yano Y, Hoop B. A comparison of 82Rb and 13NH3 for myocardial positron scintigraphy. J Nucl Med 1975; 16: 429–31.

    PubMed  CAS  Google Scholar 

  42. Parkey RW, Lewis SE, Stokely EM, Bonte FJ. Compartmental analysis of the 133Xe regional myocardial blood-flow curve. Radiology 1972; 104: 425–6.

    PubMed  CAS  Google Scholar 

  43. Herd JA, Hollenberg M, Thorburn GD, Kopala HH, Barger AC. Myocardial blood flow determined with krypton 85 in unanaesthetized dogs. Am J Physiol 1962; 203: 122–4.

    PubMed  CAS  Google Scholar 

  44. Ross RS, Ueda K, Lichtlen PR et al. Measurement of myocardial blood flow in animals and man by selective injection of radioactive inert gas into the coronary arteries. Circ Res 1964; 15: 28–41.

    Article  PubMed  CAS  Google Scholar 

  45. Cannon PJ, Dell RB, Dwyer EM Jr. Measurement of regional myocardial perfusion in man with 133 Xe and a scintillation camera. J Clin Invest 1972; 51: 964–77.

    Article  PubMed  CAS  Google Scholar 

  46. Maseri A, Mancini P. The evaluation of regional myocardial perfusion in man by a scintillation camera computer system. In: Maseri A, editor, Myocardial blood flow in man. Torino: Minerva Medica 1972: 219–29.

    Google Scholar 

  47. Holman BL, Adams DF, Jewitt D et al. Measuring regional myocardial blood flow with 133Xe and the Anger camera. Radiology 1974; 112: 99–107.

    PubMed  CAS  Google Scholar 

  48. Schmidt DH, Weiss MB, Casarella WJ, Fowler DL, Sciacca RR, Canron PJ. Regional myocardial perfusion during atrial pacing in patients with coronary artery disease. Circulation 1976; 53: 807–19.

    Article  PubMed  CAS  Google Scholar 

  49. Maseri A, l’Abbate A, Pesola A, Michelassi C, Marzilli M, De Nes M. Regional myocardial perfusion in patients with atherosclerotic coronary artery disease at rest and during angina pectoris induced by tachycardia. Circulation 1977; 55: 423–33.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Willem J. Remme
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Cardiology, University Hospital Leiden, Building 1, C5-P25 Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    Ernst E. van der Wall

  2. Department of Cardiology, University of Vienna, Garnisongasse 13, A-1090, Vienna, Austria

    Heinz Sochor

  3. Department of Cardiology, Hôpital Cantonal Universitaire, CH-1211, Geneva, Switzerland

    Alberto Righetti

  4. Department of Nuclear Medicine, University Hospital Leiden, Building 1, C4-Q-80 Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    Menco G. Niemeyer

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Remme, W.J. (1992). Myocardial perfusion and krypton-81m. In: van der Wall, E.E., Sochor, H., Righetti, A., Niemeyer, M.G. (eds) What’s New in Cardiac Imaging?. Developments in Cardiovascular Medicine, vol 133. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2456-0_5

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-2456-0_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5083-8

  • Online ISBN: 978-94-011-2456-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation