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Magnetic resonance imaging using paramagnetic contrast agents in the clinical evaluation of myocardial infarction

  • Chapter
What’s New in Cardiac Imaging?

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 133))

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Summary

Magnetic resonance imaging (MRI) is a noninvasive and specific method for production of high resolution tomographic images in blocks of three-dimensional information. Apart from scintigraphic techniques and computed tomography for the evaluation of myocardial ischemia and infarcts, MRI has emerged as a new diagnostic technique to study the extent of anatomical and functional abnormalities in patients with coronary artery disease. Conventional noncontrast MRI can identify acutely infarcted myocardial areas, although the difficulty in identifying myocardial ischemia and infarcts with noncontrast MRI suggests a potential role for contrast enhanced MRI. The use of the paramagnetic contrast agent gadolinium (Gd)-diethylene triamine pentaacetic acid (DTPA) improves depiction of infarcted myocardium on Tl-weighted spin-echo MR images that are obtained soon after acute myocardial infarction. This is of particular interest for the estimation of myocardial infarct size. Furthermore, ultrafast subsecond imaging, in combination with Gd-DTPA, offers the potential to analyze cardiac first pass and myocardial perfusion. The development of nontoxic paramagnetic contrast agents which are selectively taken up by viable myocardium would be helpful in assessing the presence of ischemic/infarcted myocardium and myocardial salvage by MRI following reperfusion.

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Authors
  1. Paul R. M. van Dijkman
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  2. Ernst E. van der Wall
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Editor information

Editors and Affiliations

  1. Department of Cardiology, University Hospital Leiden, Building 1, C5-P25 Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    Ernst E. van der Wall

  2. Department of Cardiology, University of Vienna, Garnisongasse 13, A-1090, Vienna, Austria

    Heinz Sochor

  3. Department of Cardiology, Hôpital Cantonal Universitaire, CH-1211, Geneva, Switzerland

    Alberto Righetti

  4. Department of Nuclear Medicine, University Hospital Leiden, Building 1, C4-Q-80 Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    Menco G. Niemeyer

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© 1992 Springer Science+Business Media Dordrecht

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van Dijkman, P.R.M., van der Wall, E.E. (1992). Magnetic resonance imaging using paramagnetic contrast agents in the clinical evaluation of myocardial infarction. In: van der Wall, E.E., Sochor, H., Righetti, A., Niemeyer, M.G. (eds) What’s New in Cardiac Imaging?. Developments in Cardiovascular Medicine, vol 133. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2456-0_15

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  • DOI: https://doi.org/10.1007/978-94-011-2456-0_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5083-8

  • Online ISBN: 978-94-011-2456-0

  • eBook Packages: Springer Book Archive

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