Abstract
Transferases have been used for the synthesis of chiral compounds in the series of aminoacids and monosaccharides. Aminotransferases from porcine heart and bacteria have allowed the synthesis of substituted L-glutamic acids as well as hydrophobic and hydroxylated aminoacids from 2-ketoacids. Transketolase led to analogs of ketoses by transfer of an hydroxyacetyl group on an aldehyde. Various analogs of L-erythrulose and D-xylulose have been obtained. Transketolase also led to aldoses, such as D-threose and L-glucose by transfer of a formyl group on an aldehyde.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Christen P., (1985) n TRANSAMINASES, D.E. Metzler Ed., Wiley, N.Y.
Braustein, A.E. (1973), The Enzymes, P.D. Boyer Ed., 9, 379,
Braustein, A.E. (1973), The Enzymes, P.D. Boyer Ed., 9, 1973,
Winter, H.C. and Dekker, E.E. (1989) Plant Physiol., 89, 1122.
Passerat, N. and Bolte, J. (1987), Tetrahedron Lett., 28, 1277.
Constant, O. (1991), Thèse d’Université, Université Blaise Pascal de Clermont-Ferrand.
Chesne, S. and Pelmont, J. (1973), Biochimie; 55, 237.
Tachiki, T. and Tochikura, T. (1973), Agr. Biol. Chem., 37, 1439.
Koide, Y., Houma, M. and Shimomura, T. (1977), Agr. Biol. Chem., 41, 781.
Toone E.J., Simon, E.S., Bednarski, M.D. and Whitesides, G.M. (1989), Tetrahedron, 45, 5365.
Druecckammer, D.G., Hennen, W.J., Pedersen, R.L., Barbas, C.F., Gautheron, C.M., Krach, T. and Wong, C.H. (1991), Synthesis, 499.
Straub, C.A., Effenberger, F. and Fisher, P. (1990), J. Org. Chem., 55, 3926.
Fessner, W.D., Sinerius, G., Schneider, A., Dreyer, M., Schulz, G.E., Badia, J. and Aguilar, J. (1991), Angew. Chem. Int. Ed., 30, 555.
Wood, T. (1973), Prep. Biochem., 3, 509.
Bolte, J., Demuynck, C. and Samaki, H. (1987), Tetrahedron Lett., 28, 5525.
Demuynck, C., Bolte, J., Hecquet, L. and Dalmas, V. (1991), 32, 5085.
Ziegler, T., Straub, A. and Effenberger, F. (1988), Angew. Chem. Int. Ed., 29, 716.
Myles, D.C., Andrulis, P.J. and Whitesides, G.M. (1991), Tetrahedron Lett, 32, 4835.
Demuynck, C., Bolte, J., Hecquet, L. and Samaki, H. (1990) Carbohydr. Res., 206, 79.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Bolte, J., Demuynck, C., Constant, O., Hecquet, L. (1992). Transferase Catalyzed Synthesis: Applications in Series of Aminoacids and Monosaccharides. In: Servi, S. (eds) Microbial Reagents in Organic Synthesis. NATO ASI Series, vol 381. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2444-7_5
Download citation
DOI: https://doi.org/10.1007/978-94-011-2444-7_5
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-5078-4
Online ISBN: 978-94-011-2444-7
eBook Packages: Springer Book Archive