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Approaches to 2-Methyl-1-Alkanols of High Enantiomeric Purities Via Enzyme Mediated Reactions

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Microbial Reagents in Organic Synthesis

Part of the book series: NATO ASI Series ((ASIC,volume 381))

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Abstract

Methods for the preparation of chiral nonracemic 2-methylalkanols are reviewed with emphasis on microbial processes. Special attention is devoted to two reactions: 1. (S)-2-methylalkanols were obtained from the bakers’ yeast reduction of 2-methyl-3-(2-thienyl)propenals to the corresponding (S)-2-methylthienylpropanols followed by Raney nickel reduction and 2. Racemic 2-methylalkanoic acids were resolved via esterification using lipase from Candida cylindracea.

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  1. University College of Sundsvall / Härnösand, Box 860, S-851 24, Sundsvall, Sweden

    Hans-Erik Högberg

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  1. Dipartimento di Chimica, Politecnico di Milano, Milano, Italy

    Stefano Servi

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Högberg, HE. (1992). Approaches to 2-Methyl-1-Alkanols of High Enantiomeric Purities Via Enzyme Mediated Reactions. In: Servi, S. (eds) Microbial Reagents in Organic Synthesis. NATO ASI Series, vol 381. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2444-7_32

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  • DOI: https://doi.org/10.1007/978-94-011-2444-7_32

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